論文

査読有り 本文へのリンクあり
2016年1月1日

A numerical model of a red blood cell infected by Plasmodium falciparum malaria: coupling cell mechanics with ligand-receptor interactions

Science and Technology of Advanced Materials
  • Shunichi Ishida
  • ,
  • Yohsuke Imai
  • ,
  • Yuki Ichikawa
  • ,
  • Stephanie Nix
  • ,
  • Daiki Matsunaga
  • ,
  • Toshihiro Omori
  • ,
  • Takuji Ishikawa

17
1
開始ページ
454
終了ページ
461
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1080/14686996.2016.1211462
出版者・発行元
TAYLOR & FRANCIS LTD

© 2016 Informa UK Limited, trading as Taylor & Francis Group. We developed a numerical model of the behavior of a red blood cell infected by Plasmodium falciparum malaria on a wall in shear flow. The fluid and solid mechanics of an infected red blood cell (Pf-IRBC) were coupled with the biochemical interaction of ligand-receptor bindings. We used the boundary element method for fluid mechanics, the finite element method for membrane mechanics, and the Monte Carlo method for ligand-receptor interactions. We simulated the behavior of a Pf-IRBC in shear flow, focusing on the effects of bond type. For slip bonds, the Pf-IRBC exhibited firm adhesion, tumbling motion, and tank-treading motion, depending on the applied shear rate. The behavior of catch bonds resembled that of slip bonds, except for a ‘catch’ state at high shear stress. When the reactive compliance decreased to a value in the order of 10-2 nm, both the slip and catch bonds behaved like an ideal bond. Such bonds do not respond to the force applied to the bond, and the velocity is stabilized at a high shear rate. Finally, we compared the numerical results with previous experiments for A4- and ItG-infected cells. We found that the interaction between PfEMP1 and ICAM-1 could be a nearly ideal bond, with a dissociation rate ranging from 30 s-1 to 100 s-1.

Web of Science ® 被引用回数 : 2

リンク情報
DOI
https://doi.org/10.1080/14686996.2016.1211462
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000382525800011&DestApp=WOS_CPL
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85019102068&origin=inward 本文へのリンクあり
Scopus Citedby
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