論文

査読有り 本文へのリンクあり
2019年

Coupling between dynamic 3D tissue architecture and BMP morphogen signaling during Drosophila wing morphogenesis

Proceedings of the National Academy of Sciences of the United States of America
  • Jinghua Gui
  • ,
  • Yunxian Huang
  • ,
  • Martin Montanari
  • ,
  • Daniel Toddie-Moore
  • ,
  • Kenji Kikushima
  • ,
  • Stephanie Nix
  • ,
  • Yukitaka Ishimoto
  • ,
  • Osamu Shimmi

116
10
開始ページ
4352
終了ページ
4361
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1073/pnas.1815427116
出版者・発行元
NATL ACAD SCIENCES

© 2019 National Academy of Sciences. All Rights Reserved. At the level of organ formation, tissue morphogenesis drives developmental processes in animals, often involving the rearrangement of two-dimensional (2D) structures into more complex three-dimensional (3D) tissues. These processes can be directed by growth factor signaling pathways. However, little is known about how such morphological changes affect the spatiotemporal distribution of growth factor signaling. Here, using the Drosophila pupal wing, we address how decapentaplegic (Dpp)/ bone morphogenetic protein (BMP) signaling and 3D wing morphogenesis are coordinated. Dpp, expressed in the longitudinal veins (LVs) of the pupal wing, initially diffuses laterally within both dorsal and ventral wing epithelia during the inflation stage to regulate cell proliferation. Dpp localization is then refined to the LVs within each epithelial plane, but with active interplanar signaling for vein patterning/differentiation, as the two epithelia appose. Our data further suggest that the 3D architecture of the wing epithelia and the spatial distribution of BMP signaling are tightly coupled, revealing that 3D morphogenesis is an emergent property of the interactions between extracellular signaling and tissue shape changes.

Web of Science ® 被引用回数 : 1

リンク情報
DOI
https://doi.org/10.1073/pnas.1815427116
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30760594
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000460242100065&DestApp=WOS_CPL
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85062671467&origin=inward 本文へのリンクあり
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85062671467&origin=inward

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