Yuriko Sobu

Profile Information

Affiliation: Hokkaido University

Degree: Ph.D. (Pharmaceutical Science)(Mar, 2018, Hokkaido University)

J-GLOBAL ID: 202101018442998809
researchmap Member ID: R000026927

Papers

Brain p3-Alcβ peptide restores neuronal viability impaired by Alzheimer's amyloid β-peptide.

Saori Hata, Haruka Saito, Takeharu Kakiuchi, Dai Fukumoto, Shigeyuki Yamamoto, Kensaku Kasuga, Ayano Kimura, Koichi Moteki, Ruriko Abe, Shungo Adachi, Shoich Kinoshita, Kumiko Yoshizawa-Kumagaye, Hideki Nishio, Takashi Saito, Takaomi C Saido, Tohru Yamamoto, Masaki Nishimura, Hidenori Taru, Yuriko Sobu, Hiroyuki Ohba, Shingo Nishiyama, Norihiro Harada, Takeshi Ikeuchi, Hideo Tsukada, Yasuomi Ouchi, Toshiharu Suzuki

EMBO molecular medicine, 15(5) e17052, May 8, 2023
Accumulation of amyloid-β in the brain of mouse models of Alzheimer's disease is modified by altered gene expression in the presence of human apoE isoforms during aging.

Keiko Honda, Yuhki Saito, Haruka Saito, Megumi Toyoda, Ruriko Abe, Takashi Saito, Takaomi C Saido, Makoto Michikawa, Hidenori Taru, Yuriko Sobu, Saori Hata, Tadashi Nakaya, Toshiharu Suzuki

Neurobiology of aging, 123 63-74, Mar, 2023
Measuring Axonal Cargo Transport in Mouse Primary Cortical Cultured Neurons.

Yuriko Sobu, Toshiharu Suzuki

Journal of visualized experiments : JoVE, (192), Feb 24, 2023
γ-Secretase structure and activity are modified by alterations in its membrane localization and ambient environment.

Toshiharu Suzuki, Yuriko Sobu, Saori Hata

Journal of biochemistry, 171(3) 253-256, Mar 3, 2022
Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain.

Shahzad S Khan, Yuriko Sobu, Herschel S Dhekne, Francesca Tonelli, Kerryn Berndsen, Dario R Alessi, Suzanne R Pfeffer

eLife, 10, Oct 18, 2021 Peer-reviewed
Suppression of amyloid-β secretion from neurons by cis-9, trans-11-octadecadienoic acid, an isomer of conjugated linoleic acid.

Saori Hata, Kuniyuki Kano, Kazunori Kikuchi, Shoichi Kinoshita, Yuriko Sobu, Haruka Saito, Takashi Saito, Takaomi C Saido, Yoshitake Sano, Hidenori Taru, Junken Aoki, Hiroto Komano, Taisuke Tomita, Shunji Natori, Toshiharu Suzuki

Journal of neurochemistry, 159(3) 603-617, Aug 11, 2021 Peer-reviewed
LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade.

Herschel S Dhekne, Izumi Yanatori, Edmundo G Vides, Yuriko Sobu, Federico Diez, Francesca Tonelli, Suzanne R Pfeffer

Life science alliance, 4(5), May, 2021 Peer-reviewed
Pathogenic LRRK2 regulates ciliation probability upstream of tau tubulin kinase 2 via Rab10 and RILPL1 proteins.

Yuriko Sobu, Paulina S Wawro, Herschel S Dhekne, Wondwossen M Yeshaw, Suzanne R Pfeffer

Proceedings of the National Academy of Sciences of the United States of America, 118(10), Mar 9, 2021 Peer-reviewedLead author
X11 and X11-like proteins regulate the level of extrasynaptic glutamate receptors.

Rika Motodate, Haruka Saito, Yuriko Sobu, Saori Hata, Yuhki Saito, Tadashi Nakaya, Toshiharu Suzuki

Journal of neurochemistry, 148(4) 480-498, Feb, 2019 Peer-reviewed
The cytoplasmic region of the amyloid β-protein precursor (APP) is necessary and sufficient for the enhanced fast velocity of APP transport by kinesin-1.

Maoko Tsukamoto, Kyoko Chiba, Yuriko Sobu, Yuzuha Shiraki, Yuka Okumura, Saori Hata, Akira Kitamura, Tadashi Nakaya, Seiichi Uchida, Masataka Kinjo, Hidenori Taru, Toshiharu Suzuki

FEBS letters, 592(16) 2716-2724, Aug, 2018 Peer-reviewed
Phosphorylation of multiple sites within an acidic region of Alcadein α is required for kinesin-1 association and Golgi exit of Alcadein α cargo.

Yuriko Sobu, Keiko Furukori, Kyoko Chiba, Angus C Nairn, Masataka Kinjo, Saori Hata, Toshiharu Suzuki

Molecular biology of the cell, 28(26) 3844-3856, Dec 15, 2017 Peer-reviewedLead author
Phosphorylation of KLC1 modifies interaction with JIP1 and abolishes the enhanced fast velocity of APP transport by kinesin-1.

Kyoko Chiba, Ko-Yi Chien, Yuriko Sobu, Saori Hata, Shun Kato, Tadashi Nakaya, Yasushi Okada, Angus C Nairn, Masataka Kinjo, Hidenori Taru, Rong Wang, Toshiharu Suzuki

Molecular biology of the cell, 28(26) 3857-3869, Dec 15, 2017 Peer-reviewed
Facilitation of brain mitochondrial activity by 5-aminolevulinic acid in a mouse model of Alzheimer's disease.

Chiori Omori, Rika Motodate, Yuzuha Shiraki, Kyoko Chiba, Yuriko Sobu, Ayano Kimura, Tadashi Nakaya, Hikaru Kondo, Satoshi Kurumiya, Toru Tanaka, Kazuo Yamamoto, Motowo Nakajima, Toshiharu Suzuki, Saori Hata

Nutritional neuroscience, 20(9) 538-546, Nov, 2017 Peer-reviewed
キネシン軽鎖のリン酸化によるJIP1を介したAPPとkinesin-1の接続制御と軸索輸送修飾

鈴木利治, 千葉杏子, 蘇武佑里子, 白木柚葉, 羽田沙緒里

Dementia Japan, 31(4) 566-566, Oct, 2017
Cytoplasmic fragment of Alcadein α generated by regulated intramembrane proteolysis enhances amyloid β-protein precursor (APP) transport into the late secretory pathway and facilitates APP cleavage.

Norio Takei, Yuriko Sobu, Ayano Kimura, Satomi Urano, Yi Piao, Yoichi Araki, Hidenori Taru, Tohru Yamamoto, Saori Hata, Tadashi Nakaya, Toshiharu Suzuki

The Journal of biological chemistry, 290(2) 987-95, Jan 9, 2015 Peer-reviewed

Misc.

Alcadeinα細胞質ドメインのリン酸化による機能調節

蘇武佑里子, 羽田沙緒里, 鈴木利治

日本生化学会大会プログラム・講演要旨集, 87回 [4P-012], Oct, 2014
Regulated axonal transport of APP and alcadein by kinesin-1

Toshiharu Suzuki, Kyoko Chiba, Yuka Okumura, Yuzuha Shiraki, Yuriko Sobu, Masataka Kinjo, Saori Hata, Hidenori Taru

FASEB JOURNAL, 28(1), Apr, 2014
Alcadeinのリン酸化

蘇武佑里子, 古郡慶子, 森島真帆, 羽田沙緒里, 鈴木利治

日本生化学会大会プログラム・講演要旨集, 85回 2P-244, Dec, 2012

Research Projects

Analysis of multiple mechanisms of APP axonal transport

Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2024
Phosphorylation of Alcadein cytoplasmic domain regulates its axonal transport

Grants-in-Aid for Scientific Research Grant-in-Aid for JSPS Fellows, Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018

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