2020年5月
Cocaine has some effect on neuromedin U expressing neurons related to the brain reward system.
Heliyon
- 巻
- 6
- 号
- 5
- 開始ページ
- e03947
- 終了ページ
- e03947
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.heliyon.2020.e03947
- 出版者・発行元
- Elsevier BV
Neuromedin U (NMU) is a bioactive neuropeptide, highly distributed in the gastrointestinal tract and the central nervous system. NMU has various physiological functions related to feeding behavior, energy metabolism, stress responses, circadian rhythmicity and inflammation. Recently, several reports indicate that the central NMU system plays an important role in the reward systems in the brain. However, the underlying molecular mechanisms are not yet fully defined. In this study, we found that some of cocaine-induced c-Fos immunoreactive cells were co-localized with NMU in the nucleus accumbens (NAc), caudate putamen (CPu), and basolateral amygdala (BLA), which are key brain regions associated with the brain reward system, in wild type mice. Whereas, a treatment with cocaine did not influence the kinetics of NMU or NMU receptors mRNA expression in these brain regions, and NMU-knockout mice did not show any higher preference for cocaine compared with their control mice. These results indicate that cocaine has some effect on NMU expressing neurons related to the brain reward system, and this suggests NMU system may have a role on the brain reward systems activated by cocaine.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.heliyon.2020.e03947
- ISSN : 2405-8440
- PubMed ID : 32462086
- PubMed Central 記事ID : PMC7240118