論文

査読有り
2016年5月

Lithium carbonate as a treatment for paliperidone extended-release-induced leukopenia and neutropenia in a patient with schizoaffective disorder; a case report

BMC PSYCHIATRY
  • Hiroki Matsuura
  • ,
  • Sohei Kimoto
  • ,
  • Izumi Harada
  • ,
  • Satoshi Naemura
  • ,
  • Kazuhiko Yamamuro
  • ,
  • Toshifumi Kishimoto

16
開始ページ
161
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1186/s12888-016-0874-x
出版者・発行元
BIOMED CENTRAL LTD

Background: Antipsychotic drug treatment can potentially lead to adverse events such as leukopenia and neutropenia. Although these events are rare, they represent serious and life-threatening hematological side effects.
Case presentation: We present a case study of a patient with schizoaffective disorder in a 50-year-old woman. We report a case of paliperidone extended-release (ER)-induced leukopenia and neutropenia in a female patient with schizoaffective disorder. Initiating lithium carbonate treatment and decreasing the dose of valproic acid improved the observed leukopenia and neutropenia. This treatment did not influence psychotic symptoms.
Conclusion: The combination of paliperidone ER and valproic acid induces increased paliperidone ER plasma levels. Lithium carbonate was successfully used to treat paliperidone ER-induced leukopenia and neutropenia.

Web of Science ® 被引用回数 : 4

リンク情報
DOI
https://doi.org/10.1186/s12888-016-0874-x
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27229149
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000377067200001&DestApp=WOS_CPL