論文

国際誌
2022年

Effect of D-mannose on Philadelphia chromosome-positive leukemia cells.

Cancer biomarkers : section A of Disease markers
  • Seiichi Okabe
  • ,
  • Yuko Tanaka
  • ,
  • Akihiko Gotoh

34
3
開始ページ
337
終了ページ
346
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3233/CBM-210141

BACKGROUND: Although Abelson (ABL) tyrosine kinase inhibitors (TKIs) have demonstrated potency against chronic myeloid leukemia (CML), resistance to ABL TKIs can develop in CML patients after discontinuation of therapy. OBJECTIVE: Glucose metabolism may be altered in CML cells because glucose is a key metabolite used by tumor cells. We investigated whether D-mannose treatment induced metabolic changes in CML cells and reduced CML growth in the presence of ABL TKIs. METHODS: We investigated whether D-mannose treatment induced metabolic changes in CML cells and reduced CML growth in the presence of ABL TKIs. RESULTS: Treatment with D-mannose for 72 h inhibited the growth of K562 cells. Combined treatment using ABL TKIs and D-mannose induced a significantly higher level of cytotoxicity in Philadelphia chromosome (Ph)-positive leukemia cells than in control cells. In the mouse model, severe toxicity was observed as evidenced by body weight loss in the ponatinib and D-mannose combination treatment groups. CONCLUSION: Our results indicate that metabolic reprogramming may be a useful strategy against Ph-positive leukemia cells. However, caution should be exercised during clinical applications.

リンク情報
DOI
https://doi.org/10.3233/CBM-210141
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/35001876
ID情報
  • DOI : 10.3233/CBM-210141
  • PubMed ID : 35001876

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