論文

査読有り 国際誌
2021年3月9日

Posttranslational regulation of multiple clock-related transcription factors triggers cold-inducible gene expression in Arabidopsis.

Proceedings of the National Academy of Sciences of the United States of America
  • Satoshi Kidokoro
  • Kentaro Hayashi
  • Hiroki Haraguchi
  • Tomona Ishikawa
  • Fumiyuki Soma
  • Izumi Konoura
  • Satomi Toda
  • Junya Mizoi
  • Takamasa Suzuki
  • Kazuo Shinozaki
  • Kazuko Yamaguchi-Shinozaki
  • 全て表示

118
10
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1073/pnas.2021048118

Cold stress is an adverse environmental condition that affects plant growth, development, and crop productivity. Under cold stress conditions, the expression of numerous genes that function in the stress response and tolerance is induced in various plant species, and the dehydration-responsive element (DRE) binding protein 1/C-repeat binding factor (DREB1/CBF) transcription factors function as master switches for cold-inducible gene expression. Cold stress strongly induces these DREB1 genes. Therefore, it is important to elucidate the mechanisms of DREB1 expression in response to cold stress to clarify the perception and response of cold stress in plants. Previous studies indicated that the central oscillator components of the circadian clock, CIRCADIAN CLOCK-ASSOCIATED 1 (CCA1) and LATE ELONGATED HYPOCOTYL (LHY), are involved in cold-inducible DREB1 expression, but the underlying mechanisms are not clear. We revealed that the clock-related MYB proteins REVEILLE4/LHY-CCA1-Like1 (RVE4/LCL1) and RVE8/LCL5 are quickly and reversibly transferred from the cytoplasm to the nucleus under cold stress conditions and function as direct transcriptional activators of DREB1 expression. We found that CCA1 and LHY suppressed the expression of DREB1s under unstressed conditions and were rapidly degraded specifically in response to cold stress, which suggests that they act as transcriptional repressors and indirectly regulate the cold-inducible expression of DREB1s We concluded that posttranslational regulation of multiple clock-related transcription factors triggers cold-inducible gene expression. Our findings clarify the complex relationship between the plant circadian clock and the regulatory mechanisms of cold-inducible gene expression.

リンク情報
DOI
https://doi.org/10.1073/pnas.2021048118
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33649234
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958436
ID情報
  • DOI : 10.1073/pnas.2021048118
  • PubMed ID : 33649234
  • PubMed Central 記事ID : PMC7958436

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