Sotaro Kikuchi

Profile Information

Affiliation: 助教, 未来基礎医学教室, 奈良県立医科大学

Degree: 博士(理学)

Researcher number: 90866386
J-GLOBAL ID: 201901004739228485
researchmap Member ID: B000355287

Research Interests

Structural Biology

Research Areas

Life sciences / Structural biochemistry /

Research History

Sep, 2019 - Present

Assistant Professor, Future Basic Medicine, Nara Medical University
Jun, 2014 - Aug, 2019

Postdoctoral researcher, University of Texas Southwestern Medical Center

Papers

C9orf72-Derived Proline:Arginine Poly-Dipeptides Modulate Cytoskeleton and Mechanical Stress Response

Tomo Shiota, Riko Nagata, Sotaro Kikuchi, Hitoki Nanaura, Masaya Matsubayashi, Mari Nakanishi, Shinko Kobashigawa, Noriyoshi Isozumi, Takao Kiriyama, Kazuaki Nagayama …

Frontiers in Cell and Developmental Biology, 10, Mar 23, 2022
C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers.

Hitoki Nanaura, Honoka Kawamukai, Ayano Fujiwara, Takeru Uehara, Yuichiro Aiba, Mari Nakanishi, Tomo Shiota, Masaki Hibino, Pattama Wiriyasermkul, Sotaro Kikuchi …

Nature communications, 12(1) 5301-5301, Sep 6, 2021
Gene Expression Profiles of Human Cerebral Organoids Identify PPAR Pathway and PKM2 as Key Markers for Oxygen-Glucose Deprivation and Reoxygenation

Naoki Iwasa, Takeshi K. Matsui, Naohiko Iguchi, Kaoru Kinugawa, Naritaka Morikawa, Yoshihiko M. Sakaguchi, Tomo Shiota, Shinko Kobashigawa, Mari Nakanishi, Masaya Matsubayashi …

Frontiers in Cellular Neuroscience, 15, Jun 8, 2021
27-Hydroxycholesterol regulates human SLC22A12 gene expression through estrogen receptor action.

Masaya Matsubayashi, Yoshihiko M Sakaguchi, Yoshiki Sahara, Hitoki Nanaura, Sotaro Kikuchi, Arvand Asghari, Linh Bui, Shinko Kobashigawa, Mari Nakanishi, Riko Nagata …

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 35(1) e21262, Jan, 2021
Inhibition of the ATR kinase enhances 5-FU sensitivity independently of nonhomologous end-joining and homologous recombination repair pathways.

Soichiro S Ito, Yosuke Nakagawa, Masaya Matsubayashi, Yoshihiko M Sakaguchi, Shinko Kobashigawa, Takeshi K Matsui, Hitoki Nanaura, Mari Nakanishi, Fumika Kitayoshi, Sotaro Kikuchi …

The Journal of biological chemistry, 295(37) 12946-12961, Sep 11, 2020
Human URAT1/SLC22A12 gene promoter is regulated by 27-hydroxycholesterol through estrogen response elements

Masaya Matsubayashi, Yoshihiko M. Sakaguchi, Yoshiki Sahara, Hitoki Nanaura, Sotaro Kikuchi, Arvand Ashari, Linh Bui, Shinko Kobashigawa, Mari Nakanishi, Riko Nagata …

Nov 6, 2019
Toxic PR poly-dipeptides encoded by the C9orf72 repeat expansion target Kapβ2 and dysregulate phase separation of low-complexity domains

Hitoki Nanaura, Honoka Kawamukai, Ayano Fujiwara, Takeru Uehara, Mari Nakanishi, Tomo Shiota, Masaki Hibino, Yuichiro Aiba, Pattama Wiriyasermkul, Sotaro Kikuchi …

Oct 21, 2019
Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling.

Eunhee Choi, Sotaro Kikuchi, Haishan Gao, Karolina Brodzik, Ibrahim Nassour, Adam Yopp, Amit G Singal, Hao Zhu, Hongtao Yu

Nature communications, 10(1) 1473-1473, Apr 1, 2019 Peer-reviewed
Scc2 Is a Potent Activator of Cohesin's ATPase that Promotes Loading by Binding Scc1 without Pds5.

Naomi J Petela, Thomas G Gligoris, Jean Metson, Byung-Gil Lee, Menelaos Voulgaris, Bin Hu, Sotaro Kikuchi, Christophe Chapard, Wentao Chen, Eeson Rajendra …

Molecular cell, 70(6) 1134-1148, Jun 21, 2018 Peer-reviewed
Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment-maintaining phosphoprotein (CAMP).

Kodai Hara, Shota Taharazako, Masanori Ikeda, Hiroki Fujita, Yoshiko Mikami, Sotaro Kikuchi, Asami Hishiki, Hideshi Yokoyama, Yoshinobu Ishikawa, Shin-Ichiro Kanno …

The Journal of biological chemistry, 292(43) 17658-17667, Oct 27, 2017 Peer-reviewed
Structural basis for the molecular interactions in DNA damage tolerances.

Hiroshi Hashimoto, Asami Hishiki, Kodai Hara, Sotaro Kikuchi

Biophysics and physicobiology, 14 199-205, 2017 Peer-reviewed
Crystal structure of the cohesin loader Scc2 and insight into cohesinopathy.

Sotaro Kikuchi, Dominika M Borek, Zbyszek Otwinowski, Diana R Tomchick, Hongtao Yu

Proceedings of the National Academy of Sciences of the United States of America, 113(44) 12444-12449, Nov 1, 2016 Peer-reviewed
Identification of the first small-molecule inhibitor of the REV7 DNA repair protein interaction.

Marcelo L Actis, Nigus D Ambaye, Benjamin J Evison, Youming Shao, Murugendra Vanarotti, Akira Inoue, Ezelle T McDonald, Sotaro Kikuchi, Richard Heath, Kodai Hara …

Bioorganic & medicinal chemistry, 24(18) 4339-4346, Sep 15, 2016 Peer-reviewed
A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin.

Akira Inoue, Sotaro Kikuchi, Asami Hishiki, Youming Shao, Richard Heath, Benjamin J Evison, Marcelo Actis, Christine E Canman, Hiroshi Hashimoto, Naoaki Fujii

The Journal of biological chemistry, 289(10) 7109-20, Mar 7, 2014 Peer-reviewed
A missense mutation in Rev7 disrupts formation of Polζ, impairing mouse development and repair of genotoxic agent-induced DNA lesions.

Maryam Khalaj, Abdolrahim Abbasi, Hiroshi Yamanishi, Kouyou Akiyama, Shuso Wakitani, Sotaro Kikuchi, Michiko Hirose, Misako Yuzuriha, Masaki Magari, Heba A Degheidy …

The Journal of biological chemistry, 289(6) 3811-24, Feb 7, 2014 Peer-reviewed
Structural basis of recruitment of DNA polymerase ζ by interaction between REV1 and REV7 proteins.

Sotaro Kikuchi, Kodai Hara, Toshiyuki Shimizu, Mamoru Sato, Hiroshi Hashimoto

The Journal of biological chemistry, 287(40) 33847-52, Sep 28, 2012 Peer-reviewed
Crystallization and X-ray diffraction analysis of the ternary complex of the C-terminal domain of human REV1 in complex with REV7 bound to a REV3 fragment involved in translesion DNA synthesis.

Sotaro Kikuchi, Kodai Hara, Toshiyuki Shimizu, Mamoru Sato, Hiroshi Hashimoto

Acta crystallographica. Section F, Structural biology and crystallization communications, 68(Pt 8) 962-4, Aug 1, 2012 Peer-reviewed

Misc.

Crystal Structure of the Cohesin Loader Scc2

菊池壮太郎, YU Hongtao

日本結晶学会誌, 59(2-3) 121‐126(J‐STAGE)-126, 2017
DNAに傷があっても複製を続けるための分子メカニズム

橋本博, 菱木麻美, 原幸大, 菊池壮太郎

生物物理(Web), 57(1) 015‐019(J‐STAGE)-19, 2017

Research Projects

減数分裂期の染色体軸形成を担うコヒーシンとHORMAD1の構造機能解析

科学研究費助成事業, 若手研究, 日本学術振興会, Apr, 2021 - Mar, 2023

菊池壮太郎
Regulatory mechanism of biological phase separation

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2023

Profile Information

Research Interests

Research Areas

Research History

Papers

Misc.

Research Projects

Menu

Coauthors