Research Projects

Apr, 2016 - Mar, 2018

The relationship between the mechanical force and the interaction of skin-immune system during wound healing process

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research
  • Kawai Kenichiro

Grant number
16K15755
Grant amount
(Total)
3,380,000 Japanese Yen
(Direct funding)
2,600,000 Japanese Yen
(Indirect funding)
780,000 Japanese Yen

Hypertrophic Scar is a condition where high accumulation of collagen can be seen which is promoted by the excessive wound healing process. Main factors causing hypertrophic scar are (1). stretching force of wound site and (2). inflammation of wound. Although we tried to investigate the interaction between fibroblasts and dendritic cells under stretched condition, the research did not work well. However, meanwhile, we found the interaction between keratinocyte and fibroblasts under cyclic stretched condition. It is known that keratinocytes secret Endothelin-1 in response to the stretching force. In our study, cyclic stretching force is found to enhance the expression of Endothelin Receptor B and its coupling ion channel; TRPC3 and the sensitivity to Endothelin -1 signaling is increased. These findings suggest that the interaction between fibroblasts and keratinocytes during the wound healing process contribute to the formation of hypertrophic scar.

Link information
URL
https://kaken.nii.ac.jp/file/KAKENHI-PROJECT-16K15755/16K15755seika.pdf
ID information
  • Grant number : 16K15755