論文

査読有り 最終著者 責任著者 国際誌
2016年3月

Astaxanthin supplementation enhances adult hippocampal neurogenesis and spatial memory in mice.

Molecular nutrition & food research
  • Jang Soo Yook
  • ,
  • Masahiro Okamoto
  • ,
  • Randeep Rakwal
  • ,
  • Junko Shibato
  • ,
  • Min Chul Lee
  • ,
  • Takashi Matsui
  • ,
  • Hyukki Chang
  • ,
  • Joon Yong Cho
  • ,
  • Hideaki Soya

60
3
開始ページ
589
終了ページ
99
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/mnfr.201500634
出版者・発行元
WILEY-BLACKWELL

SCOPE: There is a growing necessity for efficacious natural supplements with antioxidant effects on the brain, in particular, hippocampal function. One such compound, which also has a neuroprotective effect, is the carotenoid astaxanthin (ASX). Despite ASX's potential benefit to the brain, very little is known about its effect on hippocampal plasticity and cognition. Thus, we investigated the effect of ASX on adult hippocampal neurogenesis (AHN) and spatial memory using a mouse model. METHODS AND RESULTS: Dose-response was examined in mice fed ASX-supplemented diets (0, 0.02, 0.1, and 0.5%) to define the effect of ASX on AHN. In conjunction with AHN results, hippocampus-dependent cognitive function was assessed. We delineated molecular mechanisms associated with ASX-enhanced AHN using DNA microarray analysis. Results revealed that ASX enhanced cell proliferation and survival at 0.1% and 0.5% doses. Newborn mature neurons were higher only with 0.5% ASX, which also enhanced spatial memory. Transcriptomic profiling revealed potential AHN-associated molecules (Prl, Itga4, and Il4) that were ASX induced. Their downstream factors, identified through Ingenuity Pathway Analysis, were positively correlated with ASX-induced increases in spatial memory. CONCLUSION: ASX supplementation enhanced AHN and spatial memory, and a DNA microarray approach provided, for the first time, novel molecular insights into ASX action.

リンク情報
DOI
https://doi.org/10.1002/mnfr.201500634
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26643409
ID情報
  • DOI : 10.1002/mnfr.201500634
  • ISSN : 1613-4125
  • PubMed ID : 26643409

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