Hiroaki Adachi

J-GLOBAL         Last updated: Mar 24, 2019 at 02:40
 
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Name
Hiroaki Adachi
E-mail
hiadachimed.uoeh-u.ac.jp
Affiliation
University of Occupational and Environmental Health,Japan
Section
School of Medicine
Research funding number
40432257
ORCID ID
0000-0002-9302-4663

Profile

I have been studying the pathogenesis of polyglutamine diseases and trying to develop treatments for 13 years. Neurodegenerative disorders including polyglutamine diseases, amyotrophic lateral sclerosis, Parkinson’s disease, and Alzheimer disease are featured by progressive dysfunction and death of cells in selected areas in the nervous system. Much progress has been made in understanding the mechanisms of these diseases, effective treatments have not yet been established. One of these is spinal and bulbar muscular atrophy (SBMA), characterized by premature muscular exhaustion, progressive muscular weakness, atrophy, and fasciculation in bulbar and limb muscles. In SBMA, a polymorphic CAG repeat with 14-32 CAGs expands to 40-62 CAGs in the first exon of the androgen receptor (AR) gene. We have already examined several therapeutic approaches in a SBMA mouse model. As a consequence, we confirmed that castration and leuprorelin, a lutenizing hormone-releasing hormone agonist that reduces testosterone release from the testis, significantly rescued motor dysfunction and nuclear accumulation of mutant AR in male transgenic mice. Although this hormonal therapy was effective, it poses the unavoidable difficulty of severe sexual dysfunction. Most regrettably, this therapy cannot be applied to other polyQ diseases. Therefore, we have been trying to develop another treatments, such as stimulating the function of molecular chaperones and ubiquitin proteasome system that detoxicate and degrade abnormal proteins.
Heat shock proteins (HSPs), which function mainly as molecular chaperones, play an important role in the folding and quality control of proteins. The histopathologic hallmark of neurodegenerative diseases is accumulation and/or inclusions of the disease-causing proteins in residual neurons in targeted regions of the nervous system. The inclusions combine with many components of molecular chaperone pathways and ubiquitin-proteasome, raising the possibility that misfolding and altered degradation of mutant proteins may be involved in the pathogenesis of neurodegenerative diseases. Overexpression of HSPs reduced the number and size of inclusions and accumulation of disease-causing proteins, and ameliorated the phenotypes in neuronal cell and mouse disease models. Hsp70 over-expression also enhanced degradation of polyglutamine-expanded proteins via its interaction with the UPS. CHIP (carboxyl terminus of Hsc70-interacting protein) might be one such coupling factor between the Hsp70 chaperone system and the machinery responsible for degrading mutant proteins. When CHIP was over-expressed, the motor and pathological phenotypes were markedly ameliorated, and this amelioration was correlated with the reduction of monomeric mutant AR and mutant AR protein complexes in the SBMA model. We also demonstrated that Hsp90 inhibitors selectively degraded the mutant AR, and inhibited neuronal nuclear accumulation of the mutant AR and significantly ameliorates motor phenotypes of the SBMA model mouse. Elucidation of its pathophysiology using animal models has led to the development of disease-modifying drugs, i.e., Hsp90 inhibitor and Hsp inducer, which inhibit the pathogenic process of neuronal degeneration. These findings may provide the basis for development of an HSP-related therapy for neurodegenerative diseases. But it is necessary to develop more highly specific strong therapies. The goal of my research is to establish effective treatments of these diseases.

Research Interests

 
 

Research Areas

 
 
  • Clinical internal medicine / Neurology / 

Academic & Professional Experience

 
Apr 2014
 - 
Today
Professor, Department of Neurology, University of Occupational and Environmental Health School of Medicine
 
Nov 2013
 - 
Mar 2014
Associate professor, Department of therapeutics for intractable neurological disorders, Nagoya University Graduate School of Medicine
 
Nov 2012
 - 
Oct 2013
Associate Professor, Department of Neurology, Nagoya University Graduate School of Medicine
 
Oct 2007
 - 
Oct 2012
Assistant Professor, Department of Neurology, Nagoya University Graduate School of Medicine
 

Published Papers

 
Halievski K, Nath SR, Katsuno M, Adachi H, Sobue G, Breedlove SM, Lieberman AP, Jordan CL
International journal of molecular sciences   20(6)    Mar 2019   [Refereed]
Mitsuhashi S, Frith MC, Mizuguchi T, Miyatake S, Toyota T, Adachi H, Oma Y, Kino Y, Mitsuhashi H, Matsumoto N
Genome biology   20(1) 58   Mar 2019   [Refereed]
Kodama N, Moriguchi Y, Takeda A, Maeda M, Ando T, Kikuchi H, Gondo M, Adachi H, Komaki G
BioPsychoSocial medicine      Oct 2018   [Refereed]
Youfen Xu, Katherine Halievski, Masahisa Katsuno, Hiroaki Adachi, Gen Sobue, S Marc Breedlove, Cynthia L Jordan
Human Molecular Genetics      Jul 2018   [Refereed]
Mitsui S, Otomo A, Nozaki M, Ono S, Sato K, Shirakawa R, Adachi H, Aoki M, Sobue G, Shang H.-F, Hadano S.
Molecular Brain   11(1)    2018   [Refereed]
Ninomiya H, Ohgami N, Oshino R, Kato M, Ohgami K, Li X, Shen D, Iida M, Yajima I, Angelidis C.E, Adachi H, Katsuno M, Sobue G, Kato M.
Hearing Research   363 49-54   2018   [Refereed]
Hashimoto T, Sennari Y, Okada K, Adachi H.
Internal Medicine   57(11) 1669-1670   2018   [Refereed]
Kobori S, Kubo T, Otani M, Muramatsu K, Fujino Y, Adachi H, Horiguchi H, Fushimi K, Matsuda S
Journal of epidemiology      Mar 2017   [Refereed]
Toyota T, Sennari Y, Okada K, Kawahara A, Tsukada J, Shimajiri S, Adachi H, Neurology, vol. 88, no. 3, pp. 329-330
88(3) 329-330   Jan 2017   [Refereed]
Toyota T, Sennari Y, Okada K, Kawahara A, Tsukada J, Shimajiri S, Adachi H, Neurology, 2017, vol. 88, no. 3, pp. 329-330, 2017
Kakeda S, Yoneda T, Ide S, Miyata M, Hashimoto T, Futatsuya K, Watanabe K, Ogasawara A, Moriya J, Sato T, Okada K, Uozumi T, Adachi H, Korogi Y.
European Radiology   26(11) 1-11   Nov 2016   [Refereed]
Kino Y, Washizu C, Kurosawa M, Yamada M, Doi H, Takumi T, Adachi H, Katsuno M, Sobue G, Hicks G.G, Hattori N, Shimogori T, Nukina N.
Scientific Reports   6 35236   Oct 2016   [Refereed]
Yasuda C, Takei T, Uozumi T, Toyota T, Yuhi T, Adachi H, Rinsho shinkeigaku = Clinical neurology
Rinsho Shinkeigaku   56(9) 600-604   Sep 2016   [Refereed]
Yasuda C, Takei T, Uozumi T, Toyota T, Yuhi T, Adachi H, Rinsho shinkeigaku = Clinical neurology, 2016, 2016
Ding Y, Adachi H, Katsuno M, Sahashi K, Kondo N, Iida M, Tohnai G, Nakatsuji H, Sobue G, Neuroscience, vol. 327, pp. 20-31
Neuroscience   327 20-31   Jul 2016   [Refereed]
Ding Y, Adachi H, Katsuno M, Sahashi K, Kondo N, Iida M, Tohnai G, Nakatsuji H, Sobue G, Neuroscience, 2016, vol. 327, pp. 20-31
Hijikata Y, Katsuno M, Suzuki K, Hashizume A, Araki A, Yamada S, Inagaki T, Iida M, Noda S, Nakanishi H, Banno H, Mano T, Hirakawa A, Adachi H, Watanabe H, Yamamoto M, Sobue G, Annals of clinical, translational neurology, vol. 3, no. 7, pp. 537-546
Annals of clinical, translational neurology   3(7) 537-546   Jul 2016   [Refereed]
Hijikata Y, Katsuno M, Suzuki K, Hashizume A, Araki A, Yamada S, Inagaki T, Iida M, Noda S, Nakanishi H, Banno H, Mano T, Hirakawa A, Adachi H, Watanabe H, Yamamoto M, Sobue G, Annals of clinical and translational neurology, 2016, vol. 3, no. 7, p...
Huang Z, Adachi H, Journal of UOEH, vol. 38, no. 2, pp. 139-148
Journal of UOEH   38(2) 139-148   Jun 2016   [Refereed]
Huang Z, Adachi H, Journal of UOEH, 2016, vol. 38, no. 2, pp. 139-148, 2016
Xu Y, Halievski K, Henley C, Atchison WD, Katsuno M, Adachi H, Sobue G, Breedlove SM, Jordan CL
The Journal of neuroscience   36(18) 5094-5106   May 2016   [Refereed]
Xu Y, Halievski K, Henley C, Atchison WD, Katsuno M, Adachi H, Sobue G, Breedlove SM, Jordan CL, The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, vol. 36, no. 18, pp. 5094-5106
Ohnari K, Okada K, Takahashi T, Mafune K, Adachi H
Journal of the neurological sciences   364 97-101   May 2016   [Refereed]
Ohnari K, Okada K, Takahashi T, Mafune K, Adachi H, Journal of the neurological sciences, 2016, vol. 364, pp. 97-101
Adachi H
Brain, development   48(3) 188-194   May 2016   [Refereed]
Adachi H, No to hattatsu. Brain and development, 2016, vol. 48, no. 3, pp. 188-194, 2016
Futatsuya K, Kakeda S, Yoneda T, Ueda I, Watanabe K, Moriya J, Murakami Y, Ide S, Ogasawara A, Ohnari N, Okada K, Adachi H, Korogi Yl
Magnetic resonance in medical sciences   15(4) 349-354   Feb 2016   [Refereed]
Futatsuya K, Kakeda S, Yoneda T, Ueda I, Watanabe K, Moriya J, Murakami Y, Ide S, Ogasawara A, Ohnari N, Okada K, Adachi H, Korogi Y, Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Med...
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Autophagy, vol. 12, no. 1, pp. 1-222
Autophagy   12(1) 1-222   Jan 2016   [Refereed]
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Autophagy, 2...
Toyota T, Akamatsu N, Tanaka A, Yamano M, Fujino Y, Adachi H.
Neurol Clin Neurosci   4(1) 3-9   Jan 2016   [Refereed]
Ying Ding, Hiroaki Adachi, Masahisa Katsuno, Zhe Huang, Yue-Mei Jiang, Naohide Kondo, Madoka Iida, Genki Tohnai, Hideaki Nakatsuji, Hiroshi Funakoshi, Toshikazu Nakamura, Gen Sobue
Biochemical and Biophysical Research Communications   468(4) 677   Dec 2015   [Refereed]
Sahashi K, Katsuno M, Hung G, Adachi H, Kondo N, Nakatsuji H, Tohnai G, Iida M, Bennett CF, Sobue G, Human molecular genetics, vol. 24, no. 21, pp. 5985-5994
24(21) 5985-5994   Nov 2015   [Refereed]
Sahashi K, Katsuno M, Hung G, Adachi H, Kondo N, Nakatsuji H, Tohnai G, Iida M, Bennett CF, Sobue G, Human molecular genetics, 2015, vol. 24, no. 21, pp. 5985-5994
Kobata M, Okada K, Hashimoto T, Matsuyama A, Uchibori A, Takahashi T, Adachi H.
Neurol Clin Neurosci   3(6) 223-225   Nov 2015   [Refereed]
Toyota T, Huang Z, Nohara S, Okada K, Kakeda S, Korogi Y, Nakayama T, Sone J, SobueG, Adachi H.
Neurol Clin Neurosci   3(6) 238-240   Aug 2015   [Refereed]
Halievski K, Henley CL, Domino L, Poort JE, Fu M, Katsuno M, Adachi H, Sobue G, Breedlove SM, Jordan CL, Experimental neurology, vol. 269, pp. 224-232
269 224-232   Jul 2015   [Refereed]
Halievski K, Henley CL, Domino L, Poort JE, Fu M, Katsuno M, Adachi H, Sobue G, Breedlove SM, Jordan CL, Experimental neurology, 2015, vol. 269, pp. 224-232
Oki K, Halievski K, Vicente L, Xu Y, Zeolla D, Poort J, Katsuno M, Adachi H, Sobue G, Wiseman RW, Breedlove SM, Jordan CL
Journal of applied physiology (Bethesda, Md. : 1985)   118(7) 941-952   Apr 2015   [Refereed]
Oki K, Halievski K, Vicente L, Xu Y, Zeolla D, Poort J, Katsuno M, Adachi H, Sobue G, Wiseman RW, Breedlove SM, Jordan CL, Journal of applied physiology (Bethesda, Md. : 1985), 2015, vol. 118, no. 7, pp. 941-952
Kawagashira Y, Koike H, Ohyama K, Hashimoto R, Iijima M, Adachi H, Katsuno M, Chapman M, Lunn M, Sobue G
Journal of the neurological sciences   348(1-2) 67-73   Jan 2015   [Refereed]
Kawagashira Y, Koike H, Ohyama K, Hashimoto R, Iijima M, Adachi H, Katsuno M, Chapman M, Lunn M, Sobue G, Journal of the neurological sciences, 2015, vol. 348, no. 1-2, pp. 67-73
Iida M, Katsuno M, Nakatsuji H, Adachi H, Kondo N, Miyazaki Y, Tohnai G, Ikenaka K, Watanabe H, Yamamoto M, Kishida K, Sobue G
Human molecular genetics   24(2) 314-329   Jan 2015   [Refereed]
Iida M, Katsuno M, Nakatsuji H, Adachi H, Kondo N, Miyazaki Y, Tohnai G, Ikenaka K, Watanabe H, Yamamoto M, Kishida K, Sobue G, Human molecular genetics, 2015, vol. 24, no. 2, pp. 314-329
Halievski K, Henley C.L, Domino L, Poort J.E, Fu M, Katsuno M, Adachi H, Sobue G, Breedlove S.M, Jordan C.L.
Experimental Neurology   269 224-232   2015   [Refereed]
Kawagashira Y, Koike H, Ohyama K, Hashimoto R, Iijima M, Adachi H, Katsuno M, Chapman M, Lunn M, Sobue G.
Journal of the Neurological Sciences   348(1-2) 67-73   2015   [Refereed]
Oki K, Halievski K, Vicente L, Xu Y, Zeolla D, Poort J, Katsuno M, Adachi H, Sobue G, Wiseman R.W, Breedlove S.M, Jordan C.L.
Journal of Applied Physiology   118(7) 941-952   2015   [Refereed]
Ding Y, Adachi H, Katsuno M, Huang Z, Jiang Y.-M, Kondo N, Iida M, Tohnai G, Nakatsuji H, Funakoshi H, Nakamura T, Sobue G.
Biochemical and Biophysical Research Communications   468(4) 677-683   2015   [Refereed]
Iida M, Katsuno M, Nakatsuji H, Adachi H, Kondo N, Miyazaki Y, Tohnai G, Ikenaka K, Watanabe H, Yamamoto M, Kishida K, Sobue G.
Human Molecular Genetics   24(2) 314-329   2015   [Refereed]
Sahashi K, Katsuno M, Hung G, Adachi H, Kondo N, Nakatsuji H, Tohnai G, Iida M, Bennett C.F, Sobue G.
Human Molecular Genetics   24(21) 5985-5994   2015   [Refereed]
Tohnai G, Adachi H, Katsuno M, Doi H, Matsumoto S, Kondo N, Miyazaki Y, Iida M, Nakatsuji H, Qiang Q, Ding Y, Watanabe H, Yamamoto M, Ohtsuka K, Sobue G
Human molecular genetics   23(13) 3552-3565   Jul 2014   [Refereed]
Tohnai G, Adachi H, Katsuno M, Doi H, Matsumoto S, Kondo N, Miyazaki Y, Iida M, Nakatsuji H, Qiang Q, Ding Y, Watanabe H, Yamamoto M, Ohtsuka K, Sobue G, Human molecular genetics, 2014, vol. 23, no. 13, pp. 3552-3565
Renier KJ, Troxell-Smith SM, Johansen JA, Katsuno M, Adachi H, Sobue G, Chua JP, Sun Kim H, Lieberman AP, Breedlove SM, Jordan CL
Endocrinology   155(7) 2624-2634   Jul 2014   [Refereed]
Renier KJ, Troxell-Smith SM, Johansen JA, Katsuno M, Adachi H, Sobue G, Chua JP, Sun Kim H, Lieberman AP, Breedlove SM, Jordan CL, Endocrinology, 2014, vol. 155, no. 7, pp. 2624-2634
Ohyama K, Koike H, Katsuno M, Takahashi M, Hashimoto R, Kawagashira Y, Iijima M, Adachi H, Watanabe H, Sobue G
European journal of neurology : the official journal of the European Federation of Neurological Societies   21(7) 1002-1010   Jul 2014   [Refereed]
Ohyama K, Koike H, Katsuno M, Takahashi M, Hashimoto R, Kawagashira Y, Iijima M, Adachi H, Watanabe H, Sobue G, European journal of neurology, 2014, vol. 21, no. 7, pp. 1002-1010
Chua JP, Reddy SL, Merry DE, Adachi H, Katsuno M, Sobue G, Robins DM, Lieberman AP
Human molecular genetics   23(5) 1376-1386   Mar 2014   [Refereed]
Chua JP, Reddy SL, Merry DE, Adachi H, Katsuno M, Sobue G, Robins DM, Lieberman AP, Human molecular genetics, 2014, vol. 23, no. 5, pp. 1376-1386
Tanaka S, Banno H, Katsuno M, Suzuki K, Suga N, Hashizume A, Mano T, Araki A, Watanabe H, Adachi H, Tatsumi H, Yamamoto M, Sobue G
Journal of the neurological sciences   337(1-2) 193-200   Feb 2014   [Refereed]
Hara K, Watanabe H, Ito M, Tsuboi T, Watanabe H, Nakamura R, Senda J, Atsuta N, Adachi H, Aiba I, Naganawa S, Sobue G
Parkinsonism & related disorders   20 157-161   Feb 2014   [Refereed]
Renier K.J, Troxell-Smith S.M, Johansen J.A, Katsuno M, Adachi H, Sobue G, Chua J.P, Kim H.S, Lieberman A.P, Breedlove S.M, Jordan C.L.
Endocrinology   155(7) 2624-2634   2014   [Refereed]
Ohyama K, Koike H, Katsuno M, Takahashi M, Hashimoto R, Kawagashira Y, Iijima M, Adachi H, Watanabe H, Sobue G.
European Journal of Neurology   21(7) 1002-1010   2014   [Refereed]
Chua J.P, Reddy S.L, Merry D.E, Adachi H, Katsuno M, Sobue G, Robins D.M, Lieberman A.P.
Human Molecular Genetics   23(5) 1376-1386   2014   [Refereed]
Watanabe H, Senda J, Kato S, Ito M, Atsuta N, Hara K, Tsuboi T, Katsuno M, Nakamura T, Hirayama M, Adachi H, Naganawa S, Sobue G
Movement disorders : official journal of the Movement Disorder Society   28(12) 1732-1736   Oct 2013   [Refereed]
Watanabe H, Senda J, Kato S, Ito M, Atsuta N, Hara K, Tsuboi T, Katsuno M, Nakamura T, Hirayama M, Adachi H, Naganawa S, Sobue G, Movement disorders : official journal of the Movement Disorder Society, 2013, vol. 28, no. 12, pp. 1732-1736
Tomita M, Koike H, Kawagashira Y, Iijima M, Adachi H, Taguchi J, Abe T, Sako K, Tsuji Y, Nakagawa M, Kanda F, Takeda F, Sugawara M, Toyoshima I, Asano N, Sobue G
Brain : a journal of neurology   136(Pt 8) 2563-2578   Aug 2013   [Refereed]
Tomita M, Koike H, Kawagashira Y, Iijima M, Adachi H, Taguchi J, Abe T, Sako K, Tsuji Y, Nakagawa M, Kanda F, Takeda F, Sugawara M, Toyoshima I, Asano N, Sobue G, Brain : a journal of neurology, 2013, vol. 136, no. Pt 8, pp. 2563-2578
Qiang Q, Adachi H, Huang Z, Jiang YM, Katsuno M, Minamiyama M, Doi H, Matsumoto S, Kondo N, Miyazaki Y, Iida M, Tohnai G, Sobue G
Journal of neurochemistry   126(1) 122-130   Jul 2013   [Refereed]
Doi H, Adachi H, Katsuno M, Minamiyama M, Matsumoto S, Kondo N, Miyazaki Y, Iida M, Tohnai G, Qiang Q, Tanaka F, Yanagawa T, Warabi E, Ishii T, Sobue G
The Journal of neuroscience : the official journal of the Society for Neuroscience   33(18) 7710-7727   May 2013   [Refereed]
Matsuda M, Hoshino T, Yamakawa N, Tahara K, Adachi H, Sobue G, Maji D, Ihn H, Mizushima T
The Journal of investigative dermatology   133(4) 919-928   Apr 2013   [Refereed]
Yang YC, Fu HC, Hsiao BL, Sobue G, Adachi H, Huang FJ, Hsuuw YD, Wei KT, Chang C, Huang KE, Kang HY, Cell death, disease, vol. 4, pp. e607
4 e607   2013   [Refereed]
Yang YC, Fu HC, Hsiao BL, Sobue G, Adachi H, Huang FJ, Hsuuw YD, Wei KT, Chang C, Huang KE, Kang HY, Cell death & disease, 2013, vol. 4, pp. e607
Takagi S, Iguchi Y, Katsuno M, Ishigaki S, Ikenaka K, Fujioka Y, Honda D, Niwa J, Tanaka F, Watanabe H, Adachi H, Sobue G
PloS one   8(6) e66966   2013   [Refereed]
Kondo N, Katsuno M, Adachi H, Minamiyama M, Doi H, Matsumoto S, Miyazaki Y, Iida M, Tohnai G, Nakatsuji H, Ishigaki S, Fujioka Y, Watanabe H, Tanaka F, Nakai A, Sobue G, Nature communications, vol. 4, pp. 1405
4 1405   2013   [Refereed]
Kondo N, Katsuno M, Adachi H, Minamiyama M, Doi H, Matsumoto S, Miyazaki Y, Iida M, Tohnai G, Nakatsuji H, Ishigaki S, Fujioka Y, Watanabe H, Tanaka F, Nakai A, Sobue G, Nature communications, 2013, vol. 4, pp. 1405
Takagi S, Iguchi Y, Katsuno M, Ishigaki S, Ikenaka K, Fujioka Y, Honda D, Niwa J, Tanaka F, Watanabe H, Adachi H, Sobue G, PloS one, vol. 8, no. 6, pp. e66966
8(6) e66966   2013   [Refereed]
Takagi S, Iguchi Y, Katsuno M, Ishigaki S, Ikenaka K, Fujioka Y, Honda D, Niwa J, Tanaka F, Watanabe H, Adachi H, Sobue G, PloS one, 2013, vol. 8, no. 6, pp. e66966
Katsuno M, Tanaka F, Adachi H, Banno H, Suzuki K, Watanabe H, Sobue G
Progress in neurobiology   99(3) 246-256   Dec 2012   [Refereed]
Minamiyama M, Katsuno M, Adachi H, Doi H, Kondo N, Iida M, Ishigaki S, Fujioka Y, Matsumoto S, Miyazaki Y, Tanaka F, Kurihara H, Sobue G
Nature medicine   18(10) 1531-1538   Oct 2012   [Refereed]
Miyazaki Y, Adachi H, Katsuno M, Minamiyama M, Jiang YM, Huang Z, Doi H, Matsumoto S, Kondo N, Iida M, Tohnai G, Tanaka F, Muramatsu S, Sobue G
Nature medicine   18(7) 1136-1141   Jul 2012   [Refereed]
Katsuno M, Banno H, Suzuki K, Adachi H, Tanaka F, Sobue G
Archives of neurology   69(4) 436-440   Apr 2012   [Refereed]
Suzuki K, Banno H, Katsuno M, Adachi H, Tanaka F, Sobue G
Brain and nerve = Shinkei kenkyu no shinpo   64(3) 237-244   Mar 2012   [Refereed]
Suzuki K, Banno H, Katsuno M, Adachi H, Tanaka F, Sobue G, Brain and nerve = Shinkei kenkyu no shinpo, 2012, vol. 64, no. 3, pp. 237-244
Tanaka F, Katsuno M, Banno H, Suzuki K, Adachi H, Sobue G
Neural plasticity   2012 369284   Jan 2012   [Refereed]
Katsuno M, Banno H, Suzuki K, Hashizume A, Adachi H, Tanaka F, Sobue G
Rinsho shinkeigaku = Clinical neurology   52 1207-1209   2012   [Refereed]
Suzuki K, Banno H, Katsuno M, Adachi H, Tanaka F, Sobue G.
Brain and Nerve   64(3) 237-244   2012   [Refereed]
Katsuno M, Banno H, Suzuki K, Hashizume A, Adachi H, Tanaka F, Sobue G.
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine   101(9) 2533-2538   2012   [Refereed]
Katsumata R, Ishigaki S, Katsuno M, Kawai K, Sone J, Huang Z, Adachi H, Tanaka F, Urano F, Sobue G
PloS one   7(9) e46185   2012   [Refereed]
Adachi H
Rinsho shinkeigaku = Clinical neurology   51 1107   Nov 2011   [Refereed]
Katsuno M, Banno H, Suzuki K, Adachi H, Tanaka F, Sobue G
Rinsho shinkeigaku = Clinical neurology   51 982-985   Nov 2011   [Refereed]
Yu Z, Wang A.M, Adachi H, Katsuno M, Sobue G, Yue Z, Robins D.M, Lieberman A.P.
PLoS Genetics   7(10)    2011   [Refereed]
Sobue G, Adachi H, Katsuno M.
Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders: Second Edition   307-312   2011   [Refereed]
Hoshino T, Murao N, Namba T, Takehara M, Adachi H, Katsuno M, Sobue G, Matsushima T, Suzuki T, Mizushima T.
Journal of Neuroscience   31(14) 5225-5234   2011   [Refereed]
Katsuno M, Banno H, Suzuki K, Adachi H, Tanaka F, Sobue G.
Clinical Neurology   51(11) 982-985   2011   [Refereed]
Katsuno M, Adachi H, Banno H, Suzuki K, Tanaka F, Sobue G.
Current Molecular Medicine   11(1) 48-56   2011   [Refereed]
Katsuno M, Adachi H, Minamiyama M, Waza M, Doi H, Kondo N, Mizoguchi H, Nitta A, Yamada K, Banno H, Suzuki K, Tanaka F, Sobue G
The Journal of neuroscience : the official journal of the Society for Neuroscience   30(16) 5702-5712   Apr 2010   [Refereed]
Hoshino T, Matsuda M, Yamashita Y, Takehara M, Fukuya M, Mineda K, Maji D, Ihn H, Adachi H, Sobue G, Funasaka Y, Mizushima T
The Journal of biological chemistry   285(17) 13254-13263   Apr 2010   [Refereed]

Misc

 
安田 千春, 武井 嵩展, 魚住 武則, 豊田 知子, 由比 友顕, 足立 弘明
臨床神経学   56(9) 600-604   Sep 2016
症例は67歳女性。家族歴なし。2009年より進行性の脊椎側彎が出現し2013年他院で体幹ジストニアの診断でトリヘキシフェニジル内服とボツリヌス注射が行われたが改善はなく、2015年に歩行障害が出現した。同年5月当科での[123I]-イオフルパンシンチグラフィー(以後DATスキャン)で異常をみとめ、6月当科入院時は運動緩慢、筋強剛、右優位の静止時振戦、姿勢反射障害をみとめ頭部MRIで異常なくレボドパで運動症状の改善をみとめたことからパーキンソン病と診断した。本例は体幹ジストニアが先行したパー...
黄 哲, 足立 弘明
産業医科大学雑誌   38(2) 139-148   Jun 2016
神経変性疾患はその発症メカニズムがいまだ明確にされていない難治性疾患の一群である。罹患率は高く根本的な病態抑止治療法が確立されていない。神経変性疾患における形態学的病変では、病因となる蛋白質が神経細胞内で異常な凝集体を形成して蓄積しており、それらが細胞毒性を発揮して神経細胞死に至ると考えられている。オートファジーは、細胞内でこれらの異常蛋白質を分解するシステムとして重要な役割を果たしており、神経変性疾患の発病に強く関わっていることが知られている。従って、オートファジーは神経変性疾患の新しい...
足立 弘明
脳と発達   48(3) 188-194   May 2016
ポリグルタミン病などの神経変性疾患では、細胞内の変異蛋白質を分解するシステムであるユビキチン-プロテアソーム系(UPS)とオートファジーの機能を凌駕して変異蛋白質が蓄積し、神経変性が惹起されると考えられている。球脊髄性筋萎縮症(SBMA)は、アンドロゲン受容体(AR)遺伝子内のCAGリピートが伸長してポリグルタミン鎖が異常に延長した変異ARが産生されることによって運動ニューロンなどが特異的に機能障害および変性死に陥る疾患である。変異ARのテストステロン依存性核内集積に対するLH-RHアナロ...
【中枢性自律神経障害-最近の話題-】 神経性食欲不振症
高橋 昌稔, 兒玉 直樹, 足立 弘明
神経内科   84(1) 76-82   Jan 2016
本間 洋州, 高橋 昌稔, 兒玉 直樹, 岡田 和将, 足立 弘明
心身医学   55(10) 1155-1159   Oct 2015
目的:警告うつ病は、重症の身体疾患が発見される数週〜数ヵ月前に抑うつ状態が先駆してみられる病態を指す。今回われわれは、うつ病の精査中に骨髄異形成症候群を指摘した症例を経験したので報告する。症例:82歳女性。X-3年より両足関節〜膝の痛みと灼熱感が出現。X年1月に気力減退、喜びの喪失、倦怠感、体重減少を認めた。近医での身体精査では器質的異常を認めず、同年5月当院当科紹介となった。経過:精査目的に同年6月当科入院。大うつ病性エピソードを認め、うつ病の診断に至った。血液検査にて3系統での血球減少...
ADACHI HIROAKI
Tracer   (53) 3-11   Mar 2013
SOBUE GEN, KATSUMATA RYU, ISHIGAKI SHINSUKE, KATSUNO MASAHISA, KAWAI KAORI, SONE ATSUSHI, ADACHI HIROAKI, TANAKA FUMIAKI
神経変性疾患に関する調査研究班分科班「病態に根ざしたALSの新規治療法開発」 平成24年度 研究報告書   18-21   2013
KATSUNO MASAHISA, BANNO HARUHIKO, SUZUKI KEISUKE, HASHIZUME ATSUSHI, ADACHI HIROAKI, TANAKA FUMIAKI, SOBUE GEN
日本内科学会雑誌   101(9) 2533-2538   Sep 2012
KATSUNO Masahisa, BANNO Haruhiko, SUZUKI Keisuke, HASHIZUME Atsushi, ADACHI Hiroaki, TANAKA Fumiaki, SOBUE Gen
Nihon Naika Gakkai Kaishi   101(9) 2533-2538   Sep 2012
KATSUNO MASAHISA, SAKANO HARUHIKO, SUZUKI KEISUKE, ADACHI HIROAKI, TANAKA FUMIAKI, SOBUE GEN
遺伝子医学MOOK   (22) 87-92,12   Jul 2012
SUZUKI KEISUKE, BANNO HARUHIKO, KATSUNO MASAHISA, ADACHI HIROAKI, TANAKA FUMIAKI, SOBUE GEN
Brain Nerve   64(3) 237-244   Mar 2012
ADACHI HIROAKI, SOBUE GEN
実験医学   30(2) 394-399,180(19)   Feb 2012
KATSUNO MASAHISA, BANNO HARUHIKO, SUZUKI KEISUKE, HASHIZUME ATSUSHI, ADACHI HIROAKI, TANAKA FUMIAKI, SOBUE GEN
臨床神経学   52(11) 1207-1209 (J-STAGE)   2012
KOIKE Haruki, ATSUTA Naoki, ADACHI Hiroaki, TOMITA Minoru, MOROZUMI Saori, KAWAGASHIRA Yuichi, IIJIMA Masahiro, HATTORI Naoki, YASUDA Takeshi, FUKADA Yasuyo, YASUI Kenichi, NAKASHIMA Kenji, HORIUCHI Masahiro, SHIOMI Kazutaka, FUKUI Kazuhito, TAKASHIMA Shutaro, MORITA Yukari, KUNIYOSHI Kazumasa, HASEGAWA Yasuhiro, TORIBE Yasuhisa, SOBUE Gen
末梢神経 = Peripheral nerve   19(2) 324-326   Dec 2008

Education

 
Apr 1998
 - 
Mar 2002
Neurology, Graduate School of Medicine, Nagoya University
 
Apr 1985
 - 
Mar 1991
Medicine, School of Medicine, Nagoya University