Shigeru Shimamoto

Profile Information

Affiliation: Faculty of Science and Engineering Department of Life Science, Kindai University

Degree: 博士(薬学)(大阪大学)

J-GLOBAL ID: 201501003051591912
researchmap Member ID: B000247730

External link: https://www.kindai.ac.jp/sci/education/faculty_and_research/04_shimamoto_shigeru.html

Research Interests

Research Areas

Research History

Apr, 2015 - Present

Faculty of Science and Engineering, Department of Life Science, Kindai University
Apr, 2011 - Mar, 2014

Faculty of Science and Engineering, Department of Life Science, Kindai University
Apr, 2010 - Mar, 2011

日本学術振興会特別研究員(PD), 薬学研究科, 大阪大学大学院

Education

Apr, 2007 - Mar, 2010

分子薬科学専攻, 薬学研究科（博士後期課程）, 大阪大学大学院
Apr, 2005 - Mar, 2007

分子薬科学専攻, 薬学研究科（博士前期課程）, 大阪大学大学院
Apr, 2001 - Mar, 2005

Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Osaka University

Committee Memberships

Aug, 2021 - Present

editorial board member, The Japan Society of Calorimetry and Thermal Analysis
2017 - Present

editorial board member, Protein Science Society of Japan
Aug, 2018 - Jul, 2020

Secretary, Planning Affairs, The Japan Society of Calorimetry and Thermal Analysis

Major Papers

Substrate-induced product-release mechanism of lipocalin-type prostaglandin D synthase.

Shigeru Shimamoto, Yusuke Nakagawa, Yuji Hidaka, Takahiro Maruno, Yuji Kobayashi, Kazuki Kawahara, Takuya Yoshida, Tadayasu Ohkubo, Kosuke Aritake, Mahesh K Kaushik …

Biochemical and biophysical research communications, 569 66-71, Jul 5, 2021 Peer-reviewedLead authorCorresponding author
Chemical Digestion of the -Asp-Cys- Sequence for Preparation of Post-translationally Modified Proteins.

Shigeru Shimamoto, Natsumi Mitsuoka, Saki Takahashi, Toru Kawakami, Yuji Hidaka

The protein journal, 39(6) 711-716, Dec, 2020 Peer-reviewedLead authorCorresponding author
Topological Regulation of the Bioactive Conformation of a Disulfide-Rich Peptide, Heat-Stable Enterotoxin.

Shigeru Shimamoto, Mayu Fukutsuji, Toi Osumi, Masaya Goto, Hiroshi Toyoda, Yuji Hidaka

Molecules (Basel, Switzerland), 25(20), Oct 21, 2020 Peer-reviewedLead authorCorresponding author
ITC Analysis of Ligand Binding to Lipocalin-type Prostaglandin D Synthase

島本茂, 丸野孝浩

熱測定, 44(3) 108-116, 2017 Peer-reviewedInvitedLead authorCorresponding author

Misc.

107

Analyses of the Folding of a Cassette Mutant of Human and Eel Prouroguanylin in a Study of the Role of an Intra-Molecular Chaperone Function on Molecular Evolution

OSUMI Toi, FUKUTSUJI Mayu, MIZOE Koki, SHINTO Ryota, SHIMAMOTO Shigeru, HIDAKA Yuji

Peptide Science, 2020, 2021
Enzymatic Activities of Recombinant Cocoonase’s in which the Active Site Is Mutated

OGATA Ayumi, TAKEGAWA Mai, MIYAZAWA Mitsuhiro, SHIMAMOTO Shigeru, HIDAKA Yuji

Peptide Science, 2020, 2021
Structural Analyses of the N-terminal Extracellular Domain of the Amyloid Precursor Protein

HANAGAKI Yusaku, KANEMURA Shingo, OKUMURA Masaki, YAMAGUCHI Hiroshi, SHIMAMOTO Shigeru, HIDAKA Yuji

Peptide Science, 2020, 2021
Mechanism of Disulfide-Coupled Folding of a De Novo Designed Prouroguanylin Protein

FUKUTSUJI Mayu, OSUMI Toi, SHINTO Ryota, MIZOE Koki, SHIMAMOTO Shigeru, HIDAKA Yuji

Peptide Science, 2020, 2021
Point Mutations Suppress the Non-Specific Degradation of Cocoonase during the Refolding Reaction

TAKEGAWA Mai, OGATA Ayumi, MIYAZAWA Mitsuhiro, SHIMAMOTO Shigeru, HIDAKA Yuji

Peptide Science, 2020, 2021
Association between Disulfide-Coupled Folding and the Molecular Evolution of Prouroguanylin

MIZOE Koki, OSUMI Toi, FUKUTSUJI Mayu, SHIMAMOTO Shigeru, HIDAKA Yuji

Peptide Science, 2020, 2021
Disulfide-Coupled Folding of a De Novo Designed Hybrid Protein Derived from Eel Prouroguanylin

SHINTO Ryota, FUKUTSUJI Mayu, OSUMI Toi, MIZOE Koki, SHIMAMOTO Shigeru, HIDAKA Yuji

Peptide Science, 2020, 2021
Preparation of the Recombinant CRES Using an E. Coli Expression System

MURATA Sayuri, SHIMAMOTO Shigeru, HIDAKA Yuji

Peptide Science, 2020, 2021
Mechanism of the Disulfide-Coupled Folding of a de novo Designed Prouroguanylin Protein

Mayu Fukutsuji, Aman L. Maharjan, Toi Osumi, Shigeru Shimamoto, Yuji Hidaka

BIOPHYSICAL JOURNAL, 118(3) 508A-508A, Feb, 2020
Exploring Serum Proteins to Stabilize the Conformation of the Precursor Protein of ANP

Yuji Hidaka, Hayato Ueda, Shigeru Shimamoto

BIOPHYSICAL JOURNAL, 118(3) 59A-59A, Feb, 2020
Intra-Molecular Chaperone Mediated Folding of a Peptide Hormone in Molecular Evolution

Toi Osumi, Aman L. Maharjan, Mayu Fukutsuji, Shigeru Shimamoto, Yuji Hidaka

BIOPHYSICAL JOURNAL, 118(3) 510A-511A, Feb, 2020
Enzyme Activation Mechanism of Cocoonase

Mai Takegawa, Tsubasa Tagawa, Ayumi Ogata, Shigeru Shimamoto, Yuji Hidaka

BIOPHYSICAL JOURNAL, 118(3) 532A-532A, Feb, 2020
Mechanism of Disulfide-Coupled Folding of A de novo Designed Protein of Prouroguanylin

FUKUTSUJI Mayu, MAHARJAN Aman Lall, OSUMI Toi, SHIMAMOTO Shigeru, HIDAKA Yuji

Peptide Science, 2019, 2020
Enzyme Activation Mechanism of Cocoonase

TAKEGAWA Mai, TAGAWA Tsubasa, OGATA Ayumi, MIYAZAWA Mitsuhiro, SHIMAMOTO Shigeru, HIDAKA Yuji

Peptide Science, 2019, 2020
Cloning and Functional Analyses of Digestive Enzymes Derived from Nephila Clavata

TAGAWA Tsubasa, HAGIWARA Teruki, MIYAZAWA Mitsuhiro, SHIMAMOTO Shigeru, HIDAKA Yuji

Peptide Science, 2019, 2020
Quality Control of Disulfide-Coupled Folding of a Peptide Hormone, Uroguanylin, on Molecular Evolution

MAHARJAN Aman Lall, OSUMI Toi, FUKUTSUJI Mayu, SHIMAMOTO Shigeru, HIDAKA Yuji

Peptide Science, 2019, 2020
等温滴定型熱測定による睡眠物質合成酵素と基質の相互作用解析

島本茂, 中川悠介, 日高雄二, 丸野孝浩, 小林祐次, 河原一樹, 吉田卓也, 大久保忠恭, 有竹浩介, 裏出良博

日本細胞生物学会大会(Web), 71st, 2019
造血器型プロスタグランジンD合成酵素と補酵素・基質の分子認識機構と反応機構の解明

東野貴大, 島本茂, 日高雄二

日本細胞生物学会大会(Web), 71st, 2019
メダカ由来プロスタグランジンD合成酵素類縁体の機能解明

岩壁一樹, 鳥居希美, 島本茂, 加川尚, 日高雄二

日本細胞生物学会大会(Web), 71st, 2019
心房性ナトリウム利尿ペプチド前駆体の構造制御及び機能解析

上田隼, 島本茂, 日高雄二

日本細胞生物学会大会(Web), 71st, 2019

Books and Other Publications

熱量測定・熱分析ハンドブック

日本熱測定学会 (Role: Contributor, タンパク質と低分子の結合（ITC）ー生理活性物質ー)

丸善, Aug, 2020 (ISBN: 9784621305072)
Essential food chemistry

(Role: Contributor)

Dec, 2018 (ISBN: 9784065133415)

Teaching Experience

Apr, 2011 - Present

Organic Chemistry (Kindai University)
Apr, 2011 - Present

Bioorganic Chemistry (Kindai University)
Apr, 2011 - Present

Social Work (Kindai University)
Apr, 2011 - Present

Chemistry Laboratory (Kindai University)
Apr, 2011 - Present

Environmental Science Laboratory (Kindai University)
Apr, 2015 - Mar, 2020

Instrumental Analysis (Kindai University)
Sep, 2015 - Mar, 2016

Biochemistry (Kindai University)
Apr, 2018 - Aug, 2018

Analytical Chemistry (Kindai University)
Apr, 2018 - Present

Advanced Research (Kindai University)
Sep, 2018 - Present

Advanced studies in Life Science (Kindai University)

Professional Memberships

Apr, 2014 - Present

The Japan Society of Calorimetry and Thermal Analysis
Sep, 2011 - Present

Biophysical Society
Apr, 2011 - Present

The Japanese Peptide Society
Apr, 2007 - Present

Protein Science Society of Japan

Research Projects

Study of the Antiviral Effects of 5-ALA

Neopharma Japan, Oct, 2019 - Mar, 2021
Interaction between brain function and inflammation mediated by prostaglandin D2

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Urade Yoshihiro
substrate-induced product-release mechanism of L-PGDS

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

SHIMAMOTO SHIGERU
Relationship between precursor folding and molecular evolution of a peptide hormone

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2016

HIDAKA Yuji, YAMAGUCHI Hiroshi, SHIMAMOTO Shigeru
Product release mechanism of Lipocalin-type Prostaglandin D synthase

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2014

SHIMAMOTO Shigeru
リポカリン型プロスタグランジンD合成酵素の機能解析

科学研究費助成事業特別研究員奨励費, 特別研究員奨励費, 日本学術振興会, 2009 - 2010

島本茂

Academic Activities

The 55th Japan Conference Calorimetry and Thermal Analysis

Planning, management, etc.

KAMIYAMA Tadashi, Oct 24, 2019 - Oct 26, 2019
第56回熱測定ワークショップ｜熱測定のための電子工作とプログラミング講習会 A to Z

Planning, management, etc.

岩間世界, Aug 30, 2019 - Aug 31, 2019
Summer School 2019 | The Calorimetry and Thermal Analysis

Planning, management, etc., Panel moderator, session chair, etc., Peer review

SHIMAMOTO Shigeru, Aug 20, 2019 - Aug 21, 2019
熱測定スプリングスクール2019

Planning, management, etc., Panel moderator, session chair, etc., Peer review

鈴木俊之, Mar 7, 2019 - Mar 8, 2019
Physical Pharma Forum 2016

Planning, management, etc.

Aug 27, 2016 - Aug 28, 2016
第44回若手ペプチド夏の勉強会

Planning, management, etc., Panel moderator, session chair, etc.

島本茂；真鍋良幸, Aug 5, 2012 - Aug 7, 2012

Profile Information

Research Interests

Research Areas

Research History

Education

Committee Memberships

Major Papers

Misc.

Books and Other Publications

Teaching Experience

Professional Memberships

Research Projects

Academic Activities

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