Shingo Suzuki

Profile Information

Affiliation: Kagawa University Faculty of Medicine
: National Institute of Advanced Industrial Science and Technology

Degree: 博士（理学）(大阪大学大学院理学研究科)

J-GLOBAL ID: 201101056951011810
researchmap Member ID: 6000028765

External link

中枢神経細胞に対する脳由来神経栄養因子の作用を分子レベルで解明することが研究の目標です。また、合成生物学的研究も行っております。

Research Interests

Research Areas

Life sciences / Neuroscience - general /

Research History

2009

Medical Research Institute, Tokyo Medical and Dental University

Education

大阪大学大学院理学研究科博士後期課程

Committee Memberships

第118回日本解剖学会全国学術集会運営委員, 日本解剖学会

Papers

Ethanol concentration induces production of 3,4-dihydroxyphenylacetic acid and homovanillic acid in mouse brain through activation of monoamine oxidase pathway.

Mostofa Jamal, Asuka Ito, Takanori Miki, Shingo Suzuki, Ken-Ichi Ohta, Hiroshi Kinoshita

Neuroscience letters, 782 136689-136689, Jun 21, 2022
Brain‐derived neurotrophic factor predominantly regulates the expression of synapse‐related genes in the striatum: Insights from in vitro transcriptomics

Hisatsugu Koshimizu, Hidetada Matsuoka, Yoshihiro Nakajima, Anna Kawai, Junichiro Ono, Ken‐ichi Ohta, Takanori Miki, Masataka Sunagawa, Naoki Adachi, Shingo Suzuki

Neuropsychopharmacology Reports, 41(4) 485-495, Sep 16, 2021 Peer-reviewedLast authorCorresponding author
Meganuclease-Based Artificial Transcription Factors.

Shingo Suzuki, Ken-Ichi Ohta, Yoshihiro Nakajima, Hajime Shigeto, Hiroko Abe, Anna Kawai, Ryuichiro Miura, Yasuhiro Kazuki, Mitsuo Oshimura, Takanori Miki

ACS synthetic biology, 9(10) 2679-2691, Oct 16, 2020 Peer-reviewedLead authorCorresponding author
Repeated maternal separation causes transient reduction in BDNF expression in the medial prefrontal cortex during early brain development, affecting inhibitory neuron development

Chiaki Tenkumo, Ken-ichi Ohta, Shingo Suzuki, Katsuhiko Warita, Kanako Irie, Saki Teradaya, Takashi Kusaka, Kenji Kanenishi, Toshiyuki Hata, Takanori Miki

Heliyon, 6(8) e04781-e04781, Aug, 2020 Peer-reviewed
The effects of early life stress on the excitatory/inhibitory balance of the medial prefrontal cortex

Ken-ichi Ohta, Shingo Suzuki, Katsuhiko Warita, Kazunori Sumitani, Chiaki Tenkumo, Toru Ozawa, Hidetoshi Ujihara, Takashi Kusaka, Takanori Miki

Behavioural Brain Research, 379 112306-112306, Feb, 2020 Peer-reviewed
Vexin is up-regulated in cerebral cortical neurons by brain-derived neurotrophic factor

Hisatsugu Koshimizu, Shingo Suzuki, Anna Kawai, Ryuichiro Miura, Ken-ichi Ohta, Takanori Miki, Naoki Adachi, Hidetada Matsuoka

Neuropsychopharmacology Reports, in press(3) 275-280, 2020 Peer-reviewedLead authorCorresponding author
Corticotropin-releasing hormone-binding protein is upregulated by brain-derived neurotrophic factor and is secreted in an activity-dependent manner in rat cerebral cortical neurons.

Adachi N, Suzuki S, Matsuoka H, Fushimi S, Ono J, Ohta KI, Hirai Y, Miki T, Koshimizu H, Co-first author, co-corresponding author

J Neurochem., 146(1) 99-110, Jul, 2018 Peer-reviewedLead authorCorresponding author
The Role of Apolipoprotein E and Ethanol Exposure in Age-Related Changes in Choline Acetyltransferase and Brain-Derived Neurotrophic Factor Expression in the Mouse Hippocampus

Mostofa Jamal, Asuka Ito, Naoko Tanaka, Takanori Miki, Ayaka Takakura, Shingo Suzuki, Kiyoshi Ameno, Hiroshi Kinoshita

Journal of Molecular Neuroscience, 65(1) 84-92, May 1, 2018 Peer-reviewed
Effect of the volatile anesthetic agent isoflurane 1 on lateral diffusion of cell membrane proteins.

Ono J, Fushimi S, Suzuki S, Ameno K, Kinoshita H, Shirakami G, Kabayama K

FEBS Open Bio., 8(7) 1127-1134, May, 2018 Peer-reviewed
Yuzu (Citrus junos Tanaka) peel attenuates dextran sulfate sodium-induced murine experimental colitis

Hiroko Abe, Mika Ishioka, Yasuko Fujita, Aya Umeno, Mayu Yasunaga, Akihiko Sato, Shigehiko Ohnishi, Shingo Suzuki, Noriko Ishida, Mototada Shichiri, Yasukazu Yoshida, Yoshihiro Nakajima

Journal of Oleo Science, 67(3) 335-344, 2018 Peer-reviewed
Prolonged maternal separation attenuates BDNF-ERK signaling correlated with spine formation in the hippocampus during early brain development

Ken-ichi Ohta, Shingo Suzuki, Katsuhiko Warita, Tomohiro Kaji, Takashi Kusaka, Takanori Miki

JOURNAL OF NEUROCHEMISTRY, 141(2) 179-194, Apr, 2017 Peer-reviewed
Functional interaction between BDNF and mGluR II in vitro: BDNF down-regulated mGluR II gene expression and an mGluR II agonist enhanced BDNF-induced BDNF gene expression in rat cerebral cortical neurons.

Shingo Suzuki, Hisatsugu Koshimizu, Naoki Adachi, Hidetada Matsuoka, Satoko Fushimi, Junichiro Ono, Ken-Ichi Ohta, Takanori Miki

Peptides, 89 42-49, Mar, 2017 Peer-reviewedLead authorCorresponding author
神経毒とNeuroscienceエタノール

三木崇範, 太田健一, 鈴木辰吾

Clinical Neuroscience, (35) 1393-1397, 2017 Peer-reviewed
Development of an Artificial Calcium-Dependent Transcription Factor To Detect Sustained Intracellular Calcium Elevation

Shingo Suzuki, Kazutoshi Murotomi, Yoshihiro Nakajima, Katsuhisa Kawai, Ken-ichi Ohta, Katsuhiko Warita, Takanori Miki, Yoshiki Takeuchi

ACS SYNTHETIC BIOLOGY, 3(10) 717-722, Oct, 2014 Peer-reviewedLead authorCorresponding author
A unique pattern of bisphenol A effects on nerve growth factor gene expression in embryonic mouse hypothalamic cell line N-44

Katsuhiko Warita, Tomoko Mitsuhashi, Nobuhiko Hoshi, Ken-ichi Ohta, Shingo Suzuki, Yoshiki Takeuchi, Takanori Miki

ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY, 65(3) 293-299, Sep, 2014 Peer-reviewed
Prolonged maternal separation disturbs the serotonergic system during early brain development

Ken-ichi Ohta, Takanori Miki, Katsuhiko Warita, Shingo Suzuki, Takashi Kusaka, Tomiko Yakura, Jun-Qian Liu, Motoki Tamai, Yoshiki Takeuchi

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 33 15-21, Apr, 2014 Peer-reviewed
Short-term ethanol exposure causes imbalanced neurotrophic factor allocation in the basal forebrain cholinergic system: a novel insight into understanding the initial processes of alcohol addiction.

Takanori Miki, Takashi Kusaka, Toshifumi Yokoyama, Ken-ichi Ohta, Shingo Suzuki, Katsuhiko Warita, Mostofa Jamal, Zhi-Yu Wang, Masaaki Ueki, Jun-Qian Liu, Tomiko Yakura, Motoki Tamai, Kazunori Sumitani, Naohisa Hosomi, Yoshiki Takeuchi

Journal of neural transmission (Vienna, Austria : 1996), 121(2) 201-10, Feb, 2014 Peer-reviewed
Early postnatal repeated maternal deprivation causes a transient increase in OMpg and BDNF in rat cerebellum suggesting precocious myelination

Takanori Miki, Toshifumi Yokoyama, Takashi Kusaka, Shingo Suzuki, Ken-ichi Ohta, Katsuhiko Warita, Zhi-Yu Wang, Masaaki Ueki, Kazunori Sumitani, Frederick P. Bellinger, Motoki Tamai, Jun-Qian Liu, Tomiko Yakura, Yoshiki Takeuchi

JOURNAL OF THE NEUROLOGICAL SCIENCES, 336(1-2) 62-67, Jan, 2014 Peer-reviewed
Early postnatal maternal separation causes alterations in the expression of β3-adrenergic receptor in rat adipose tissue suggesting long-term influence on obesity.

Takanori Miki, Jun-Qian Liu, Ken-ichi Ohta, Shingo Suzuki, Takashi Kusaka, Katsuhiko Warita, Toshifumi Yokoyama, Mostofa Jamal, Masaaki Ueki, Tomiko Yakura, Motoki Tamai, Kazunori Sumitani, Naohisa Hosomi, Yoshiki Takeuchi

Biochemical and biophysical research communications, 442(1-2) 68-71, Dec 6, 2013 Peer-reviewed
The role of WGA for decreasing the accumulation of Aβ: A new approach to promote transsynaptic transport of Aβ in the rat

Jun Qian Liu, Takanori Miki, Yoshiki Matsumoto, Ken ichi Ohta, Shingo Suzuki, Katsuhiko Warita, Tomiko Yakura, Motoki Tamai, Yoshiki Takeuchi

Current Neurobiology, 4(1-2) 1-8, Aug 1, 2013

Misc.

Metabolomic analysis for Brain-derived neurotrophic factor signaling

Shingo Suzuki, Kazuyuki Kiyosue, Takeshi Kasama, Chiaki Itami, Masami Kojima, Kohichi Tanaka

NEUROSCIENCE RESEARCH, 65 S41-S41, 2009
BDNF regulared cholesterol metabolism for synapse development

Shingo Suzuki, Kazuyuki Kiyosue, Shunsuke Hazama, Akihiko Ogura, Tomoko Hara, Kouichi Tanaka, Masami Kojima

NEUROSCIENCE RESEARCH, 61 S217-S217, 2008
BDNF stimulates neuronal cholesterol biosynthesis and accumulates presynaptic proteins in lipid rafts

Shingo Suzuki, Kazuyuki Kiyosue, Shunsuke Hazama, Akihiko Ogura, Tomoko Hara, Hisatsugu Koshimizu, Masami Kojima

NEUROSCIENCE RESEARCH, 58 S20-S20, 2007
Molecular analysis of polymorphisms in human BDNF gene generating uncleaved proBDNF variants

H Koshimizu, S Suzuki, T Hara, M Kashihara, M Kojima

JOURNAL OF NEUROCHEMISTRY, 94 264-264, Aug, 2005
BDNF increases cholesterol and synaptic vesicle proteins in neuronal rafts

S Suzuki, M Kashihara, H Koshimizu, T Hara, M Kojima

JOURNAL OF NEUROCHEMISTRY, 94 265-265, Aug, 2005
Lipid rafts mediate chemotropic guidance of nerve growth cones (vol 42, pg 51, 2004)

C Guirland, S Suzuki, M Kojima, B Lu, JQ Zheng

NEURON, 42(3) 519-519, May, 2004
Lipid rafts mediate BDNF/TRKB signaling in CNS neurons

S Suzuki, T Numakawa, H Koshimizu, H Hatanaka, B Lu, M Kojima

JOURNAL OF NEUROCHEMISTRY, 88 90-90, Feb, 2004
Decreased trophic effects of BDNF SNPs variants to CNS neurons

H Koshimizu, B Lu, S Suzuki, T Hara, M Kojima

JOURNAL OF NEUROCHEMISTRY, 88 90-90, Feb, 2004
Brain-derived neurotrophic factor induced recruitment of receptor tyrosine kinase TrkB into lipid rafts in cortical neurons

S Suzuki, T Numakawa, H Koshimizu, M Kojima

JOURNAL OF NEUROCHEMISTRY, 87 124-124, Dec, 2003

Presentations

生後早期の母子分離ストレスが、脂肪組織エネルギー代謝関連因子に及ぼす影響

第119回日本解剖学会総会・全国学術集会, 2014
Transsynapic transport of WGA conjugated Amyloid-β in the nucleus of solitary tract of the rat

第118回日本解剖学会総会・全国学術集会, 2013
幼若期の不遇な養育環境が引き起こす脳発達臨界期AMPA受容体動態の異常

第53回日本先天異常学会学術集会, 2013
The role of WGA for decreasing the accumulation of Aβ：A new approach to promote transsynaptic transport of Aβ in the rat

日本解剖学会第68回中国・四国支部学術集会, 2013
Alterations of synaptic transcytosis induced by ethanol exposure: apocrine-like structure in the rat

第117回日本解剖学会総会・全国学術集会, 2012
BDNF-regulared cholesterol metabolism for synapse development

Asia Pacific Society for Neurochemistry 11th, 2012
下垂体後葉における透出および離出様分泌

Neuroscience 2011/第34回日本神経科学大会, 2011
BDNF regulated Cholesterol homeostasis in CNS neurons

NGF 2010 meeting, 2010

Professional Memberships

Research Projects

母子分離モデルから紐解く発達障害発症に関わる脳領域

科学研究費助成事業基盤研究(C), 日本学術振興会, Apr, 2019 - Mar, 2022

太田健一, 三木崇範, 鈴木辰吾, 中村信嗣, 割田克彦, 日下隆
膜受容体の流動性とシグナル伝達の関係性から見た揮発性麻酔薬作用機序の解明

科学研究費助成事業基盤研究(C), 日本学術振興会, Apr, 2019 - Mar, 2022

小野純一郎, 樺山一哉, 坂内博子, 鈴木辰吾
腸内細菌叢と脳との双方向情報伝達機構の解明－ストレスによる肥満易発症の分子基盤

科学研究費助成事業基盤研究(C), 日本学術振興会, Apr, 2018 - Mar, 2022

三木崇範, 太田健一, 鈴木辰吾, 横山俊史, 割田克彦, 金西賢治, 日下隆
周産期ストレスによる神経幹細胞分化への影響とそのメカニズム

科学研究費助成事業基盤研究(C), 日本学術振興会, Apr, 2018 - Mar, 2022

安達直樹, 鈴木辰吾
Influence of Early Life Stress on the Brain Development

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Suzuki Shingo
The Influences of maternal separation on neural circuit formation during brain development equivalent to preterm infants in human

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

OHTA Ken-ichi
Elucidation of the mechanism of action of volatile anesthetics by visualization of membrane microdomains and receptors

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Ono Junichiro, SUZUKI Shingo
Regulation of energy metabolism between brain and periferal organs; molecular mechanism of stress-induced life style-related diseases

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2018

MIKI TAKANORI
Effect of BDNF on fatty acid homeositasis during brain development

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

SUZUKI SHINGO
Analysis of molecular mechanisms involved in the susceptibility to statins on cancer cells

Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity Start-up, Japan Society for the Promotion of Science, Aug, 2014 - Mar, 2016

Warita Katsuhiko, MIKI TAKANORI, HOSAKA YOSHINAO, OHTA KEN-ICHI, SUZUKI SHINGO, WARITA TOMOKO, Oltvai Zoltan N.
Risk of learning deficit and mental disorder by prolonged maternal separation

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

OHTA Ken-ichi, TAKEUCHI Yoshiki, MIKI Takanori, SUZUKI Shingo, WARITA Katsuhiko, KUSAKA Takashi
Anesthetic effect on dynamics of membrane microdomains in living cells

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

ONO Junichiro, SUZUKI Shingo
Effect of early life stress on BDNF-mediated lipid homeostasis

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2014

SUZUKI Shingo
Ethiological mechanisms of perinatal stress on lifestyle-related diseases pathogenesis

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2010 - Mar, 2014

MIKI Takanori, OHTA Kenichi, SUZUKI Shongo, YOKOYAMA Toshifumi, KUSAKA Takashi, TAKEUCHI Yoshiki
Alterations of synaptic transcytosis induced by ethanol exposure: non-vesicular synaptic transport in the rat

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2010 - Mar, 2014

TAKEUCHI Yoshiki, MIKI Takanori, IMAGAWA Tomohiro, NAKAMURA Kazuhiko, OHTA Kenichi, SUZUKI Shingo, WARITA Katsuhiko, MATSUMOTO Yoshiki
Cholesterol metabolite-dependent regulation of synaptic development

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2010 - 2011

SUZUKI Shingo
Analysis of lipid microdomain under volatile anesthesia

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2008 - 2009

ONO Junichiro, SUZUKI Shingo
BDNFと脳の発達に関する研究

鈴木辰吾

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特開2020-065506 核酸結合因子

鈴木辰吾

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Misc.

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