論文

査読有り
2019年8月

Impact of chronic lung allograft dysfunction, especially restrictive allograft syndrome, on the survival after living-donor lobar lung transplantation compared with cadaveric lung transplantation in adults: a single-center experience.

Surgery today
  • Seiichiro Sugimoto
  • ,
  • Haruchika Yamamoto
  • ,
  • Takeshi Kurosaki
  • ,
  • Shinji Otani
  • ,
  • Mikio Okazaki
  • ,
  • Masaomi Yamane
  • ,
  • Shinichi Toyooka
  • ,
  • Takahiro Oto

49
8
開始ページ
686
終了ページ
693
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00595-019-01782-0

PURPOSE: The differences in chronic lung allograft dysfunction (CLAD) between living-donor lobar lung transplantation (LDLLT) and cadaveric lung transplantation (CLT) remain unclear. We conducted this study to compare the impact of CLAD on the outcomes after LDLLT vs. CLT. METHODS: We conducted a retrospective review of the data of 97 recipients of bilateral lung transplantation, including 51 recipients of LDLLT and 46 recipients of CLT. RESULTS: The CLAD-free survival and overall survival after LDLLT were similar to those after CLT. CLAD and restrictive allograft syndrome (RAS), but not bronchiolitis obliterans syndrome (BOS), developed significantly later after LDLLT than after CLT (p = 0.015 and p = 0.035). Consequently, patients with CLAD and RAS, but not those with BOS, after LDLLT had a significantly better overall survival than those after CLT (p = 0.037 and p = 0.0006). Furthermore, after the diagnosis of CLAD, the survival of patients with RAS after LDLLT tended to be better than that after CLT (p = 0.083). CONCLUSION: CLAD, especially RAS, appears to develop later after LDLLT than after CLT and seems to have a lower impact on the overall survival after LDLLT than that after CLT.

リンク情報
DOI
https://doi.org/10.1007/s00595-019-01782-0
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30790054
ID情報
  • DOI : 10.1007/s00595-019-01782-0
  • ISSN : 0941-1291
  • PubMed ID : 30790054

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