論文

査読有り 国際誌
2019年6月15日

exSSSRs (extracellular S100 soil sensor receptors)-Fc fusion proteins work as prominent decoys to S100A8/A9-induced lung tropic cancer metastasis.

International journal of cancer
  • Rie Kinoshita
  • ,
  • Hiroki Sato
  • ,
  • Akira Yamauchi
  • ,
  • Yuta Takahashi
  • ,
  • Yusuke Inoue
  • ,
  • I Wayan Sumardika
  • ,
  • Youyi Chen
  • ,
  • Nahoko Tomonobu
  • ,
  • Kota Araki
  • ,
  • Kazuhiko Shien
  • ,
  • Shuta Tomida
  • ,
  • Hidejiro Torigoe
  • ,
  • Kei Namba
  • ,
  • Eisuke Kurihara
  • ,
  • Yusuke Ogoshi
  • ,
  • Hitoshi Murata
  • ,
  • Ken-Ichi Yamamoto
  • ,
  • Junichiro Futami
  • ,
  • Endy Widya Putranto
  • ,
  • I Made Winarsa Ruma
  • ,
  • Hiromasa Yamamoto
  • ,
  • Junichi Soh
  • ,
  • Toshihiko Hibino
  • ,
  • Masahiro Nishibori
  • ,
  • Eisaku Kondo
  • ,
  • Shinichi Toyooka
  • ,
  • Masakiyo Sakaguchi

144
12
開始ページ
3138
終了ページ
3145
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/ijc.31945

Within the "seed and soil" theory of organ tropic cancer metastasis is a growing compilation of evidence that S100A8/A9 functions as a soil signal that attracts cancer cells to certain organs, which prove beneficial to their growth. S100A8/A9-sensing receptors including Toll-like receptor 4 (TLR4), advanced glycation end products (RAGE), and also important receptors we recently succeeded in identifying (EMMPRIN, NPTNβ, MCAM, and ALCAM) have the potential to become promising therapeutic targets. In our study, we prepared extracellular regions of these novel molecules and fused them to human IgG2-Fc to extend half-life expectancy, and we evaluated the anti-metastatic effects of the purified decoy proteins on metastatic cancer cells. The purified proteins markedly suppressed S100A8/A9-mediated lung tropic cancer metastasis. We hence expect that our novel biologics may become a prominent medicine to prevent cancer metastasis in clinical settings through cutting the linkage between "seed and soil".

リンク情報
DOI
https://doi.org/10.1002/ijc.31945
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30365872
ID情報
  • DOI : 10.1002/ijc.31945
  • ISSN : 0020-7136
  • PubMed ID : 30365872

エクスポート
BibTeX RIS