論文

査読有り 国際誌
2018年10月18日

Donor-derived cell-free DNA is associated with acute rejection and decreased oxygenation in primary graft dysfunction after living donor-lobar lung transplantation.

Scientific reports
  • Shin Tanaka
  • ,
  • Seiichiro Sugimoto
  • ,
  • Takeshi Kurosaki
  • ,
  • Kentaroh Miyoshi
  • ,
  • Shinji Otani
  • ,
  • Ken Suzawa
  • ,
  • Shinsuke Hashida
  • ,
  • Masaomi Yamane
  • ,
  • Takahiro Oto
  • ,
  • Shinichi Toyooka

8
1
開始ページ
15366
終了ページ
15366
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41598-018-33848-3

Donor-derived cell-free DNA (dd-cf-DNA) has been shown to be an informative biomarker of rejection after lung transplantation (LT) from deceased donors. However, in living-donor lobar LT, because small grafts from blood relatives are implanted with short ischemic times, the detection of dd-cf-DNA might be challenging. Our study was aimed at examining the role of dd-cf-DNA measurement in the diagnosis of primary graft dysfunction and acute rejection early after living-donor lobar LT. Immediately after LT, marked increase of the plasma dd-cf-DNA levels was noted, with the levels subsequently reaching a plateau with the resolution of primary graft dysfunction. Increased plasma levels of dd-cf-DNA were significantly correlated with decreased oxygenation immediately (p = 0.022) and at 72 hours (p = 0.046) after LT. Significantly higher plasma dd-cf-DNA levels were observed in patients with acute rejection (median, 12.0%) than in those with infection (median, 4.2%) (p = 0.028) or in a stable condition (median, 1.1%) (p = 0.001). Thus, measurement of the plasma levels of dd-cf-DNA might be useful to monitor the severity of primary graft dysfunction, and plasma dd-cf-DNA could be a potential biomarker for the diagnosis of acute rejection after LT.

リンク情報
DOI
https://doi.org/10.1038/s41598-018-33848-3
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30337621
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193971
ID情報
  • DOI : 10.1038/s41598-018-33848-3
  • PubMed ID : 30337621
  • PubMed Central 記事ID : PMC6193971

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