論文

査読有り
2019年3月

A single-nucleotide polymorphism in a gene modulating glucocorticoid sensitivity is associated with the decline in total lung capacity after lung transplantation.

Surgery today
  • Haruchika Yamamoto
  • ,
  • Seiichiro Sugimoto
  • ,
  • Shin Tanaka
  • ,
  • Takeshi Kurosaki
  • ,
  • Shinji Otani
  • ,
  • Masaomi Yamane
  • ,
  • Naruto Taira
  • ,
  • Takahiro Oto
  • ,
  • Shinichi Toyooka

49
3
開始ページ
268
終了ページ
274
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00595-018-1717-9

PURPOSE: Glucocorticoids are used to prevent chronic lung allograft dysfunction (CLAD) after lung transplantation (LT). Our study was aimed at assessing the association between the glucocorticoid-induced transcript 1 gene (GLCCI1) variant, which modulates glucocorticoid sensitivity, and the postoperative lung function and development of CLAD after LT. METHODS: A total of 71 recipients of LT were genotyped for the GLCCI1 variant (rs37972) and divided into three groups: the homozygous mutant allele (TT) group, the heterozygous mutant allele (CT) group, and the wild-type allele (CC) group. The results of pulmonary function tests were compared with the postoperative baseline values. RESULTS: The total lung capacity (TLC) in the TT group was significantly lower than that in the CC group at 3 years after LT (P = 0.029). In the recipients of cadaveric LT, the TLC and forced expiratory volume in 1 s in the TT group were significantly lower than those in the CC groups, resulting in a significant worse CLAD-free survival at 3 years after LT (P = 0.016). CONCLUSION: The GLCCI1 variant was associated with a significant decrease of the TLC at 3 years after LT and the development of CLAD at 3 years, especially in patients undergoing cadaveric LT.

リンク情報
DOI
https://doi.org/10.1007/s00595-018-1717-9
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30229311
ID情報
  • DOI : 10.1007/s00595-018-1717-9
  • ISSN : 0941-1291
  • PubMed ID : 30229311

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