論文

査読有り
2018年10月

Low-risk donor lungs optimize the post-lung transplant outcome for high lung allocation score patients.

Surgery today
  • Takeshi Kurosaki
  • ,
  • Kentaroh Miyoshi
  • ,
  • Shinji Otani
  • ,
  • Kentaro Imanishi
  • ,
  • Seiichiro Sugimoto
  • ,
  • Masaomi Yamane
  • ,
  • Motomu Kobayashi
  • ,
  • Shinichi Toyooka
  • ,
  • Takahiro Oto

48
10
開始ページ
928
終了ページ
935
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00595-018-1670-7

PURPOSE: The lung allocation score (LAS) has been generally recognized as a contributor to the overall survival in lung transplant candidates. However, donor-related risks have never been taken into consideration in previous research that validated the LAS. This study aimed to determine whether or not the role of the LAS as a predictor of the posttransplant outcome is influenced by the quality of the donor lungs. METHODS: We retrospectively reviewed 108 patients who underwent lung transplantation at Okayama University Hospital since 1998. The cohort was divided into two groups based on the lung donor score (DS; ≤ 4/> 4). Correlations between the LAS and posttransplant outcomes were investigated in both groups. RESULTS: In the high-DS group, an elevated LAS was strongly associated with posttransplant PaO2/FiO2 (p = 0.018). However, in the low-DS group, no correlation was found between them. There was no significant difference in the long-term survival according to the LAS in the low-DS group. The LAS effectively predicted the posttransplant outcome only when lungs with DS > 4 were transplanted; the LAS was not reliable if high-quality lungs were transplanted. CONCLUSION: Lung transplantation can be feasible and provides a survival benefit even for high-LAS patients if lungs from a low-risk donor are transplanted.

リンク情報
DOI
https://doi.org/10.1007/s00595-018-1670-7
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29752531
ID情報
  • DOI : 10.1007/s00595-018-1670-7
  • ISSN : 0941-1291
  • PubMed ID : 29752531

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