論文

査読有り
2015年11月

DNA copy number gains in malignant pleural mesothelioma

Oncology Letters
  • Masashi Furukawa
  • ,
  • Shinichi Toyooka
  • ,
  • Tatsuro Hayashi
  • ,
  • Hiromasa Yamamoto
  • ,
  • Nobukazu Fujimoto
  • ,
  • Junichi Soh
  • ,
  • Shinsuke Hashida
  • ,
  • Kazuhiko Shien
  • ,
  • Hiroaki Asano
  • ,
  • Keisuke Aoe
  • ,
  • Kazunori Okabe
  • ,
  • Harvey I. Pass
  • ,
  • Kazunori Tsukuda
  • ,
  • Takumi Kishimoto
  • ,
  • Shinichiro Miyoshi

10
5
開始ページ
3274
終了ページ
3278
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3892/ol.2015.3652
出版者・発行元
SPANDIDOS PUBL LTD

Malignant pleural mesothelioma (MPM) is a highly aggressive tumor with an extremely poor prognosis. The incidence of MPM is increasing as a result of widespread exposure to asbestos. The molecular pathogenesis of MPM remains unclear. The present study analyzed the frequency of various genomic copy number gains (CNGs) in MPM using reverse transcription-quantitative polymerase chain reaction. A total of 83 primary MPMs and 53 primary lung adenocarcinomas were analyzed to compare the CNGs of EGFR, KRAS, MET, FGFR1 and SOX2. In MPM, the CNGs of EGFR, KRAS, MET, FGFR1 and SOX2 were detected in 12 (14.5%), 8 (9.6%), 5 (6.0%), 4 (4.8%) and 1 (1.2%) of the samples, respectively. In lung adenocarcinomas, the CNGs of EGFR, KRAS, MET, FGFR1 and SOX2 were detected in 21 (39.6%), 12 (22.6%), 5 (9.4%), 10 (18.9%) and 0 (0.0%) of the samples, respectively. The CNGs of EGFR, KRAS and FGFR1 were significantly less frequent in the MPMs compared with the lung adenocarcinomas (P=0.0018, 0.048 and 0.018, respectively). Overall, the MPMs exhibited these CNGs less frequently compared with the lung adenocarcinomas (P=0.0002). The differences in CNGs between the two tumor types suggested that they are genetically different.

Web of Science ® 被引用回数 : 2

リンク情報
DOI
https://doi.org/10.3892/ol.2015.3652
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26722325
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000364324800100&DestApp=WOS_CPL
ID情報
  • DOI : 10.3892/ol.2015.3652
  • ISSN : 1792-1074
  • eISSN : 1792-1082
  • PubMed ID : 26722325
  • Web of Science ID : WOS:000364324800100

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