論文

査読有り
2015年9月

Ethnicity affects EGFR and KRAS gene alterations of lung adenocarcinoma

ONCOLOGY LETTERS
  • Junichi Soh
  • ,
  • Shinichi Toyooka
  • ,
  • Keitaro Matsuo
  • ,
  • Hiromasa Yamamoto
  • ,
  • Ignacio I. Wistuba
  • ,
  • Stephen Lam
  • ,
  • Kwun M. Fong
  • ,
  • Adi F. Gazdar
  • ,
  • Shinichiro Miyoshi

10
3
開始ページ
1775
終了ページ
1782
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3892/ol.2015.3414
出版者・発行元
SPANDIDOS PUBL LTD

Mutations or copy number gains (CNGs) of the EGFR and KRAS genes are representative alterations in lung adenocarcinomas that are individually associated with patient characteristics such as ethnicity, smoking status and gender. However, the effects of combinations of these genetic alterations have not been statistically examined. The present study analyzed previously examined lung adenocarcinoma cases in Asian (n=166) and non-Asian (n=136) individuals in whom all four EGFR and KRAS alterations had been studied. The polynomial logistic regression models were used following adjustment for gender and smoking status, and using patients without any type of EGFR/KRAS alterations as a reference. Between the two ethnic groups, EGFR CNGs (gEGFR) occurred more frequently than EGFR mutations (mEGFR) (46 vs. 38% in Asians; 21 vs. 10% in non-Asians), whereas KRAS mutations (mKRAS) were more frequent than KRAS CNGs (gKRAS) (13 vs. 7% and 35 vs. 4%, respectively). Additionally, gEGFR and gKRAS occurred significantly more frequently in respective mutant cases, and all EGFR alterations were almost exclusive of all KRAS alterations. The polynomial logistic regression models confirmed that all types of EGFR alterations were significantly more frequent among Asian individuals than among non-Asian individuals, independent of gender and smoking status (odds ratios, 2.36-6.67). KRAS alterations occurred less frequently among Asian individuals than among non-Asian individuals, although a significant difference was not detected. The present study results indicated that the EGFR and KRAS profiles, including mutations and CNGs, differ between Asian and non-Asian individuals with lung adenocarcinoma, suggesting that ethnicity strongly affects the molecular characteristics of lung adenocarcinoma.

Web of Science ® 被引用回数 : 18

リンク情報
DOI
https://doi.org/10.3892/ol.2015.3414
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26622749
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000360923000095&DestApp=WOS_CPL
ID情報
  • DOI : 10.3892/ol.2015.3414
  • ISSN : 1792-1074
  • eISSN : 1792-1082
  • PubMed ID : 26622749
  • Web of Science ID : WOS:000360923000095

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