論文

査読有り
2015年9月

Primary pulmonary melanoma: a report of two cases

WORLD JOURNAL OF SURGICAL ONCOLOGY
  • Mototsugu Watanabe
  • ,
  • Hiromasa Yamamoto
  • ,
  • Shinsuke Hashida
  • ,
  • Junichi Soh
  • ,
  • Seiichiro Sugimoto
  • ,
  • Shinichi Toyooka
  • ,
  • Shinichiro Miyoshi

13
開始ページ
274
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1186/s12957-015-0695-2
出版者・発行元
BIOMED CENTRAL LTD

Malignant melanoma is a refractory malignancy with a dismal prognosis. It generally arises from the skin in most cases, and cases of primary pulmonary malignant melanoma are rare and often behave aggressively. We have treated two cases of localized primary pulmonary malignant melanoma using surgical resection. Pulmonary malignant melanomas often metastasize to the brain and liver; one of our cases exhibited metastasis to the cecum at about 8 months after surgery. Because cutaneous melanomas often carry activating mutations in the BRAF gene (V600E), we performed a BRAF mutational analysis using direct sequencing for both of these tumors arising from the lung. However, no BRAF mutations were detected. We detected a p53 mutation, which was thought to be a potential somatic mutation, in one of the two cases using a sequencing panel targeting 20 lung cancer-related genes. Although we also checked the expression of programmed death ligand 1 (PD-L1) on the surface of the tumor cells by immunohistochemical testing, neither of our two cases expressed PD-L1. Further molecular analyses may uncover the characteristics of primary pulmonary malignant melanomas.

Web of Science ® 被引用回数 : 5

リンク情報
DOI
https://doi.org/10.1186/s12957-015-0695-2
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26376781
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000361451500003&DestApp=WOS_CPL
ID情報
  • DOI : 10.1186/s12957-015-0695-2
  • ISSN : 1477-7819
  • PubMed ID : 26376781
  • Web of Science ID : WOS:000361451500003

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