Papers

Feb, 2021

Volumetric PET Parameters Predict Prognosis after Definitive Chemoradiotherapy with Cisplatin/Docetaxel for Stage III Non-Small Cell Lung Cancer.

Acta medica Okayama
  • Kuniaki Katsui
  • Takeshi Ogata
  • Akihiro Tada
  • Soichi Sugiyama
  • Kotaro Yoshio
  • Masahiro Kuroda
  • Katsuyuki Kiura
  • Yoshinobu Maeda
  • Shinichi Toyooka
  • Takao Hiraki
  • Susumu Kanazawa
  • Display all

Volume
75
Number
1
First page
15
Last page
23
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.18926/AMO/61429

The aim of this study was to investigate whether volumetric positron emission tomography (PET) parameters are prognostic predictors in stage III non-small cell lung cancer patients receiving definitive concurrent chemo-radiotherapy (CCRT) with cisplatin/docetaxel. Cases involving definitive CCRT were reviewed retrospectively, and the maximum standardized uptake value, metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were calculated. The relationships between these PET parameters and prognosis were analyzed. MTV and TLG were significant predictors of distant metastasis-free survival (DMFS) (p = 0.0003 and 0.0005, respectively) and progression-free survival (PFS) (p = 0.001 and 0.0007, respectively). The three-year DMFS rates in patients with low and high MTV were 13.3% and 64.6%, respectively, and the corresponding values in those with low and high TLG were 13.3% and 65.2%, respectively. The three-year PFS rates in patients with low and high MTV were 13.3% and 57.8%, respectively, and the corresponding values in patients with low and high TLG were 13.3% and 57.8%, respectively. However, MTV and TLG were not predictors of local control or overall sur-vival. We demonstrated that volumetric PET parameters were predictors of patients receiving definitive CCRT. Our findings contradict the findings of previous reports and warrant further research to validate them.

Link information
DOI
https://doi.org/10.18926/AMO/61429
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33649609
ID information
  • DOI : 10.18926/AMO/61429
  • Pubmed ID : 33649609

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