Toshiho Ohtsuki

J-GLOBAL         Last updated: Aug 12, 2019 at 18:01
Toshiho Ohtsuki
Kindai University
Kinki University Hospotal

Research Areas

  • Clinical internal medicine / Neurology / Neurocritical Care and Stroke

Academic & Professional Experience

Jul 2011
Professor, Stroke Centre, Kindai University Hospital
Jul 2005
Jun 2011
Assistant Professor, Department of Neurogy and Clinical Neuroscience, Hiroshima University Hospital
Oct 2001
Jun 2005
Medical Doctor, Department of Internal Medicine, Stroke Branch, National Cardiovascular Center Hospital
Jul 1997
Sep 2001
Medical doctor, Department of Cardiology, Neurology and Stroke, The Hospital of Osaka University, School of Medicine
Jan 1997
Jun 1997
Osaka University, Graduate School of Medicine
Aug 1994
Dec 1996
Visiting Fellow, Stroke Branch, National Institute of Neurological Disorders and Stroke, NIH
Sep 1990
Jun 1994
Research Fellow, First Department of Internal Medicine, Osaka University, School of Medicine
Jul 1989
Aug 1990
Medical Doctor, Department of Internal Medicine, Yao Municipal Hospital
Jul 1986
Jun 1989
Medical Doctor, Department of Internal Medicine, Hoshigaoka Kosei-Nenkin Hospital


Apr 1980
Mar 1986
Medical School, Kobe Univesity

Awards & Honors

Nov 1995
Fellow Award of Research Excellence, Fogarty International Center of NIH
Mar 1994
Award for Excellent Research and Studying Abroad, Japan Heart Foundation
Apr 1992
nfluence of oxidative stress on induced tolerance to ischemia in gerbil hippocampal neurons., Kusano's Best Awards of Excellent Research, Japan Society of Stroke

Published Papers

Baseline carotid intima-media thickness and stroke recurrence during secondary prevention with pravastatin
Shinichi Wada, Masatoshi Koga, Kazuo Minematsu, Kazunori Toyoda, Rieko Suzuki, Tatsuo Kagimura, Yoji Nagai, Shiro Aoki, Tomohisa Nezu, Naohisa Hosomi, Hideki Origasa, Toshiho Ohtsuki, Hirofumi Maruyama, Masahiro Yasaka, Kazuo Kitagawa, Shinichiro Uchiyama, and Masayasu Matsumoto
Stroke   50(6) 1586-1589   Jun 2019   [Refereed]
Background and Purpose: As a pre-specified post hoc analysis of the Japan Statin Treatment Against Recurrent Stroke Echo Study, the 5-year stroke recurrence rate according to the baseline mean carotid intima-media thickness (IMT) with and without ...
Kazuo Kitagawa, Naohisa Hosomi, Yoji Nagai, Tatsuo Kagimura, Toshiho Ohtsuki, Hirofumi Maruyama, Hideki Origasa, Kazuo Minematsu, Shinichiro Uchiyama, Masakazu Nakamura, Masayasu Matsumoto, for the J-STARS collaborators
J Atheroscler Thromb.   26(5) 432-444   May 2019   [Refereed]
Aims: To investigate the relative contribution of on-treatment low-density lipoprotein (LDL) cholesterol and
C-reactive protein (CRP) to the risk of recurrent stroke and transient ischemic attack (TIA) in patients with history
of ischemic stroke.
Shinichi Wada, Masatoshi Koga, Kazunori Toyoda, Kazuo Minematsu, Masahiro Yasaka, Yoji Nagai, Shiro Aoki, Tomohisa Nezu, Naohisa Hosomi, Tatsuo Kagimura, Hideki Origasa, Kenji Kamiyama, Rieko Suzuki, Toshiho Ohtsuki, Hirofumi Maruyama, Kazuo Kitagawa, Shinichiro Uchiyama, Masayasu Matsumoto, on behalf of the Japan Statin Treatment Against Recurrent Stroke (J-STARS) Echo Study Collaborators.
J Atheroscler Thromb   25(4) 359-373   Apr 2018   [Refereed]
Long-Term Effect of Pravastatin on Carotid Intima–Media Complex Thickness The J-STARS Echo Study
Koga M, Toyoda K, Minematsu K, Yasaka M, Nagai Y, Aoki S, Nezu T, Hosomi N, Kagimura K, Suzuki, Ohtsuki T, R,Maruyama H, Kitagawa K, Uchiyama S, Matsumoto M, on behalf of the J-STARS Investigators
Stroke   49(1) 107-113   2018   [Refereed]
Background and Purpose:The effect of statins on progression of carotid intima–media complex thickness (IMT) has been shown exclusively in nonstroke Western patients. This study aimed to determine the effect of low-dose pravastatin on carotid IMT i...
Kazuo Kitagawa,Naohisa Hosomi, Yoji Nagai, Tatsuo Kagimura, Toshiho Ohtsuki, Hideki Origasa, Kazuo Minematsu,Shinichiro Uchiyama, Masakazu Nakamura, and Masayasu Matsumoto, J-STARS Investigators.
J Atheroscler Thromb.   24(10) 1039-1047   Oct 2017   [Refereed]
Mari Matsumoto, Manabu Sakaguchi, Shuhei Okazaki, Kazuo Hashikawa, Tsutomu Takahashi, Masayasu Matsumoto, Toshiho Ohtsuki, Takeshi Shimazu, Toshiki Yoshimine, Hideki Mochizuki, Kazuo Kitagawa,
Circ J   81 391-396   2017   [Refereed]
Hosomi N, Nagai Y, Kohriyama T, Ohtsuki T, Aoki S, Nezu T, Maruyama H, Sunami N, Yokota C, Kitagawa K, Terayama Y, Takagi M, Ibayashi S, Nakamura M, Origasa H, Fukushima M, Mori E, Minematsu K, Uchiyama S, Shinohara Y, Yamaguchi T, Matsumoto M,;for the J-STARS collaborators
EBioMedicine   6 1071-1078   2015   [Refereed]
Prevention of intracranial hemorrhage. III Intracranical cerebral hemorrhage. In Japanese Guidelines for the Management of Stroke 2009
Toshiho Ohtsuki
J Stroke Cerebrovasc Dis   20 s75-s77   2011   [Refereed]
Stimulation of tyrosine phosphorylation of a brain protein by hibernation.
Toshiho Ohtsuki
J. Cerebr. Blood Flow Metab.   18 1040-1045   1998   [Refereed]
Mammalian hibernation is a state of natural tolerance to severely decreased brain blood flow. As protein tyrosine phosphorylation is believed to be involved in the development of resistance to potentially cell-damaging insults, we used immunoblott...
Delayed neuronal death in ischemic hippocampus involves stimulation of protein tyrosine phosphorylation.
Toshiho Ohtsuki
Am. J. Physiol.   271 C1085-C1097   1996   [Refereed]

Books etc

Medication for stroke update
Toshiho Ohtsuki (Part:Contributor, antiplatelet drug)
May 2019   ISBN:978-4-8-8404-6615-8
Clinical Support Update 2019
Toshiho Ohtsuki (Part:Contributor, Intracranial hemorrhage)
Elsevier Japan   May 2019   
Case study of Tactical diagnosis and treatment for acute stroke
Toshiho Ohtsuki (Part:Joint Work, Intracerebral hemorrhage in antithrombotic medication)
Nanzando   Mar 2019   ISBN:978-4-525-24931-1
Medical Treatment Today, 6th ed.
Toshiho Ohtsuki (Part:Contributor, subarachnoid hemorrage)
Nankodo   Mar 2019   ISBN:978-4-534-25119-3
First line is to decrease blood pressure if systolic blood pressure exceeds 140mmHg, and the second line is to make the patient free from headache and awareness. Delayed vasospasm can be prevented by ozagrel, fasdil, and nicardipine.
Medical Treatment Today, the 6th edition.
Toshiho Ohtsuki (Part:Contributor, Cerebral Hemorrhage)
Nankodo   Mar 2019   ISBN:978-4-524-25119-3
First line is to decrease blood pressure if systolic blood pressure exceeds 150mmHg, and the second line is to replace the coagulation deficiency if available. We must keep in mind to check up the indication of neurosurgical intervention.
To stop early expansion of intracranial hemorrhage associated with antithromobotic therapy
Toshiho Ohtsuki (Part:Joint Work, Expert for stroke antithrombotic therapy)
Jan 2019   ISBN:978-4-498-32822-8
Journal of generalist medicine
Toshiho Ohtsuki (Part:Joint Work, Secondary Prevention against Stroke in the Aged.)
Aug 2018   
Primary Care for Acute Vertebro-Basilar Ischemic and Hemorrhagic Stroke
Toshiho Ohtsuki (Part:Contributor)
Jul 2018   ISBN:1346-2067
Thrombolytic treatment and subsequent secondary prevention against atherothrombotic brain infarction
Yukiko Horikawa, Toshiho Ohtsuki (Part:Joint Work)
Med J KIndai Univ 43   Jun 2018   
Clinical Support
Toshiho Ohtsuki, Masayasu Matsumoto (Part:Contributor, Brain hemorrhage)
Mar 2018   
Japanese guideline for the management of stroke 2015
Toshiho Ohtsuki (Part:Contributor, Prevention of cerebral hemorrhage)
Kyowa Publishing   Oct 2017   ISBN:978-4-87794-194-9
Make sure to lose no time fighting against hypertensive intracranial hemorrhage.
Ai Tanaka, Toshiho Ohtsuki (Part:Contributor)
Med J KIndai Univ 42   Mar 2017   
ASAKURA Internal Medicine the 11th Edition
Toshiho Ohtsuki (Part:Contributor, Cerebral Infarction)
ASAKURA   Mar 2017   ISBN:978-4-254-32260-5
Fighting against Stroke Update2017
Toshiho Ohtsuki (Part:Contributor)
Med J KIndai Univ 41   Mar 2016   
Uncommon Causes of Juvenile and Child Stroke
Toshiho Ohtsuki (Part:Contributor, Medcare or Stroke)
Feb 2016   
ASAKURA Internal Medicine the 10th Edition
Toshiho Ohtsuki, Masayasu Matsumoto (Part:Contributor, Cerebral Thrombosis)
Jun 2013   
Toshiho Ohtsuki, Masayasu Matsumoto (Part:Contributor, Stroke)
Jul 2010   ISBN:978-4-89013-394-9
Internal Medicine
Toshiho Ohtsuki, Masayasu Matsumoto (Part:Contributor, cerebral Thrombosis)
Sep 2007   

Conference Activities & Talks

Secondary prevention of aged non-cardiogenic infarction
Toshiho Ohtsuki
28 May 2019   
Immediate reversal of dabigatran with idarucizumab for the purpose of subsequent intravenous thrombolysis for acute ischemic stroke.
Toshiho Ohtsuki
5th European Stroke Organization Conference 2019   23 May 2019   European Stroke Organization
he latest officially-authorized Japanese clinical guides 2018 recommend that thrombolysis can be approved both if the time of the late dose of direct oral anticoagulants exceeds 4 hours and if commonly available anticoagulation markers are normal ...
Clinical diagnosis and treatment for acute ischemic stroke with frailty [Invited]
Toshiho Ohtsuki
16 May 2019   
Frailty and sarcopenia in stroke [Invited]
Toshiho Ohtsuki
Stroke 2019   23 Mar 2019   Japan Society of Stroke and Vascular Neurosurgery
Poor Functional Outcome after Hemorrhagic Stroke in Active Infective Endocarditis.
Toshiho Ohtsuki
European Stroke Organization Karolinska Stroke Update Conference   12 Nov 2018   European Stroke Organization
Background and Objective: Infective endocarditis (IE) suddenly causes not only ischemic stroke by bacterial emboli but also hemorrhagic stroke by inflamed arteries or aneurysms prone to rupture. Stroke in IE often makes the following valve-repairi...
Primary Care for Acute Ischemic Stroke by Orthopedic Surgeon
Toshiho Ohtsuki
16 Sep 2018   
Hemorrhagic transformation from ischemic perforating arteries around microbleed following winning rt-PA thrombolysis in the basilar branch atheromatous disease.
Toshiho Ohtsuki
5th European Stroke Organisation Conference   16 May 2018   
Uncommon Causes of Stroke [Invited]
Toshiho Ohtsuki
Stroke 2018   16 Mar 2018   Japan Society of Stroke
Prevention of Stroke [Invited]
Toshiho Ohtsuki
25 Feb 2018   
Brain Attack 2018 [Invited]
Toshiho Ohtsuki
11 Jan 2018   

Social Contribution

Stroke Forum
[TV or radio appearance, Panelist, Presenter, Chief Editor, Lecturer, Organizing Member, Report writing]  Osaka Prefecture  Jul 2011 - Today


Apr 2018   Japan ISLS Committee