論文

査読有り
2018年6月22日

Degradation of maternal factors during preimplantation embryonic development.

The Journal of reproduction and development
  • Satoshi Tsukamoto
  • ,
  • Takayuki Tatsumi

64
3
開始ページ
217
終了ページ
222
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1262/jrd.2018-039

During oogenesis, oocytes accumulate a large set of proteins derived from the maternal genome. These proteins, known as maternal proteins, are not only required for oocyte maturation and fertilization, but also implicated in subsequent embryonic development. However, most maternal proteins are degraded and their amino acid components are utilized for newly synthesized proteins from the embryonic genome. This process is known as the oocyte-to-embryo transition; because it occurs over a short period, mechanisms involving massive degradation of maternal proteins have been proposed. Intracellular protein degradation mechanisms can be broadly classified into two types. The first is the ubiquitin-proteasome system, a highly selective pathway in which ubiquitylated proteins are degraded by proteasomes. The second mechanism is autophagy, which involves lysosome-mediated degradation of cytoplasmic components. In this review, we describe recent advances in the understanding of autophagy, focusing on its role in early embryonic development.

リンク情報
DOI
https://doi.org/10.1262/jrd.2018-039
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29695651
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021607

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