論文

査読有り
2018年12月14日

How does the promoter of an oocyte-specific gene function in male germ cells?

The Journal of reproduction and development
  • Yuka Miki
  • ,
  • Satoshi Tsukamoto
  • ,
  • Naojiro Minami

64
6
開始ページ
463
終了ページ
468
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1262/jrd.2018-060

Studying gene expression in germ cells is useful for elucidating mechanisms of transcriptional regulation, because different genes are activated in male and female germ cells. The promoter regions of an oocyte-specific gene, Oog1, have been characterized. Driving the expression of green fluorescent protein with these different promoter regions provided us with critical information on the regulation of gene expression. The 3.9 kb long promoter functions in both male and female germ cells in transgenic mice. What is the cause of this sexually dimorphic expression? There may be important factors within and perhaps also outside this 3.9 kb promoter region that are required to maintain proper sex-specific gene expression.

リンク情報
DOI
https://doi.org/10.1262/jrd.2018-060
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30197401
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305850

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