Satoshi Uchida

mRNA vaccine designs for optimal adjuvanticity and delivery

Yuki Mochida, Satoshi Uchida

RNA Biology, Dec 31, 2024

Carrier-free mRNA vaccine induces robust immunity against SARS-CoV-2 in mice and non-human primates without systemic reactogenicity

Saed Abbasi, Miki Matsui-Masai, Fumihiko Yasui, Akimasa Hayashi, Theofilus A. Tockary, Yuki Mochida, Shiro Akinaga, Michinori Kohara, Kazunori Kataoka, Satoshi Uchida

Molecular Therapy, Apr, 2024

Poly(ethylene Glycol) (PEG)–OligoRNA Hybridization to mRNA Enables Fine‐Tuned Polyplex PEGylation for Spleen‐Targeted mRNA Delivery

Miki Suzuki, Yuki Mochida, Mao Hori, Akimasa Hayashi, Kazuko Toh, Theofilus A. Tockary, Xueying Liu, Victor Marx, Hidetomo Yokoo, Kanjiro Miyata …

Small Science, Feb 22, 2024

Ionizable Polymeric Micelles with Phenylalanine Moieties Enhance Intracellular Delivery of Self-Replicating RNA for Long-Lasting Protein Expression In Vivo

Lucas Mixich, Eger Boonstra, Keita Masuda, Shang-Wei Li, Yuki Nakashima, Fanlu Meng, Momoko Sakata, Tatsuro Goda, Satoshi Uchida, Horacio Cabral

Biomacromolecules, Feb 12, 2024

Hydrophobicity Tuning of Cationic Polyaspartamide Derivatives for Enhanced Antisense Oligonucleotide Delivery.

Jongmin Yum, Fadlina Aulia, Keisuke Kamiya, Mao Hori, Nan Qiao, Beob Soo Kim, Mitsuru Naito, Satomi Ogura, Tetsuya Nagata, Takanori Yokota …

Bioconjugate chemistry, Jan 30, 2024

Oligosarcosine Conjugation of Arginine-Rich Peptides Improves the Intracellular Delivery of Peptide/pDNA Complexes.

Hidetomo Yokoo, Anjaneyulu Dirisala, Satoshi Uchida, Makoto Oba

ACS biomaterials science & engineering, Dec 30, 2023

Comb-structured mRNA vaccine tethered with short double-stranded RNA adjuvants maximizes cellular immunity for cancer treatment.

Theofilus A Tockary, Saed Abbasi, Miki Matsui-Masai, Akimasa Hayashi, Naoto Yoshinaga, Eger Boonstra, Zheng Wang, Shigeto Fukushima, Kazunori Kataoka, Satoshi Uchida

Proceedings of the National Academy of Sciences of the United States of America, 120(29) e2214320120, Jul 18, 2023 Peer-reviewedLead authorLast authorCorresponding author

mRNA vaccine induces protective immunity against the type III secretory virulence ofPseudomonas aeruginosa

Ken Kawaguchi, Mao Kinoshita, Kazuki Sudo, Keita Inoue, Yoshifumi Naito, Makoto Oba, Satoshi Uchida, Teiji Sawa

Jun 10, 2023

Polyplex Designs for Improving the Stability and Safety of RNA Therapeutics

Satoshi Uchida, Chun Yin Jerry Lau, Makoto Oba, Kanjiro Miyata

Advanced Drug Delivery Reviews, 114972-114972, Jun, 2023 Lead authorCorresponding author

Cap analogs with a hydrophobic photocleavable tag enable facile purification of fully capped mRNA with various cap structures.

Masahito Inagaki, Naoko Abe, Zhenmin Li, Yuko Nakashima, Susit Acharyya, Kazuya Ogawa, Daisuke Kawaguchi, Haruka Hiraoka, Ayaka Banno, Zheyu Meng …

Nature communications, 14(1) 2657-2657, May 11, 2023 Peer-reviewed

Jet injection potentiates naked mRNA SARS-CoV-2 vaccine in mice and non-human primates by adding physical stress to the skin

Saed Abbasi, Miki Matsui-Masai, Fumihiko Yasui, Akimasa Hayashi, Theofilus A. Tockary, Shiro Akinaga, Michinori Kohara, Kazunori Kataoka, Satoshi Uchida

Feb 27, 2023

Block catiomers with flanking hydrolyzable tyrosinate groups enhance in vivo mRNA delivery via π–π stacking-assisted micellar assembly

Wenqian Yang, Takuya Miyazaki, Yasuhiro Nakagawa, Eger Boonstra, Keita Masuda, Yuki Nakashima, Pengwen Chen, Lucas Mixich, Kevin Barthelmes, Akira Matsumoto …

Science and Technology of Advanced Materials, Jan 23, 2023 Peer-reviewed

An Amphipathic Structure of a Dipropylglycine-Containing Helical Peptide with Sufficient Length Enables Safe and Effective Intracellular siRNA Delivery.

Makoto Oba, Mika Shibuya, Yuto Yamaberi, Hidetomo Yokoo, Satoshi Uchida, Atsushi Ueda, Masakazu Tanaka

Chemical & pharmaceutical bulletin, 71(3) 250-256, 2023 Peer-reviewed

高分子ベクターを用いたレプリコンRNAデリバリーを基盤としたがん遺伝子ワクチンの開発

Boonstra Eger, Mixich Lucas, Yang Wenqian, Chen Pengwen, 増田圭汰, 内田智士, Cabral Horacio

日本DDS学会学術集会プログラム予稿集, 38回 92-92, Jun, 2022

Complete Chemical Synthesis of Minimal Messenger RNA by Efficient Chemical Capping Reaction.

Naoko Abe, Akihiro Imaeda, Masahito Inagaki, Zhenmin Li, Daisuke Kawaguchi, Kaoru Onda, Yuko Nakashima, Satoshi Uchida, Fumitaka Hashiya, Yasuaki Kimura …

ACS chemical biology, 17(6) 1308-1314, May 24, 2022 Peer-reviewed

Delivery Systems of Plasmid DNA and Messenger RNA for Advanced Therapies

Satoshi Uchida

Pharmaceutics, 14(4) 810-810, Apr 7, 2022 Peer-reviewedInvitedLead authorLast authorCorresponding author

Effective mRNA Protection by Poly( l ‐ornithine) Synergizes with Endosomal Escape Functionality of a Charge‐Conversion Polymer toward Maximizing mRNA Introduction Efficiency

Anjaneyulu Dirisala, Satoshi Uchida, Junjie Li, Joachim F. R. Van Guyse, Kotaro Hayashi, Sai V. C. Vummaleti, Sarandeep Kaur, Yuki Mochida, Shigeto Fukushima, Kazunori Kataoka

Macromolecular Rapid Communications, 2100754-2100754, Mar 18, 2022 Peer-reviewedCorresponding author

Microglial Immunoregulation by Apoptotic Cellular Membrane Mimetic Polymeric Particles

Yasuhiro Nakagawa, Jeonggyu Lee, Yihua Liu, Saed Abbasi, Taehun Hong, Horacio Cabral, Satoshi Uchida, Mitsuhiro Ebara

ACS Macro Letters, Feb 15, 2022 Peer-reviewed

Tethering designer short double-stranded RNA to mRNA for co-delivery of molecularly-targeted adjuvants and antigens towards cancer vaccination

Theofilus A. Tockary, Saed Abbasi, Miki Masai, Naoto Yoshinaga, Shigeto Fukushima, Kazunori Kataoka, Satoshi Uchida

Jan 21, 2022

Cell-Penetrating Peptides: Emerging Tools for mRNA Delivery

Hidetomo Yokoo, Makoto Oba, Satoshi Uchida

Pharmaceutics, 14(1), Dec 29, 2021 Peer-reviewedLast authorCorresponding author

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