論文

査読有り
2004年3月

ERG rod a-wave in Oguchi disease

VISION RESEARCH
  • T Usui
  • ,
  • N Tanimoto
  • ,
  • S Ueki
  • ,
  • M Takagi
  • ,
  • S Hasegawa
  • ,
  • H Abe
  • ,
  • K Sekiya
  • ,
  • M Nakazawa

44
5
開始ページ
535
終了ページ
540
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.visres.2003.06.003
出版者・発行元
PERGAMON-ELSEVIER SCIENCE LTD

We analyzed the change in the ERG rod a-wave waveform during the course of dark adaptation in two patients with Oguchi disease. Two Japanese patients showed a homozygous arrestin 1147delA mutation. Scotopic flash ERGs were recorded after different periods of dark adaptation. ERG rod a-waves were obtained after subtraction of the cone ERG contribution. The rod a-waves were fitted with a model of the rod receptor signal. The parameters, Rm(p3) (maximum a-wave amplitude) and S (sensitivity) were calculated. Longer periods in the dark produced larger rod a-wave but only to the first flash presented. The amplitude of the response to subsequent flashes was essentially independent of the period of dark adaptation. Rm(p3) increased with advance of dark adaptation. However, S was nearly constant. Our results suggest that the cause of delayed dark adaptation is not to be sought in the activation of phototransduction process or the regeneration of rhodopsin per se but rather in the deactivation process of the phototransduction cascade. (C) 2003 Elsevier Ltd. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.visres.2003.06.003
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000188707900011&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.visres.2003.06.003
  • ISSN : 0042-6989
  • Web of Science ID : WOS:000188707900011

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