論文

査読有り
2017年10月

Comorbidity and quality of life in childhood cancer survivors treated with proton beam therapy

PEDIATRICS INTERNATIONAL
  • Hiroko Fukushima
  • ,
  • Takashi Fukushima
  • ,
  • Ryoko Suzuki
  • ,
  • Atsushi Iwabuchi
  • ,
  • Kyoko Hidaka
  • ,
  • Toko Shinkai
  • ,
  • Kouji Masumoto
  • ,
  • Ai Muroi
  • ,
  • Tetsuya Yamamoto
  • ,
  • Tomohei Nakao
  • ,
  • Yoshiko Oshiro
  • ,
  • Masashi Mizumoto
  • ,
  • Hideyuki Sakurai
  • ,
  • Ryo Sumazaki

59
10
開始ページ
1039
終了ページ
1045
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/ped.13323
出版者・発行元
WILEY

BackgroundThe rate of childhood cancer survival has recently reached >80%. Various adverse events among childhood cancer survivors (CCS) have been reported. Proton beams are able to avoid unnecessary irradiation to normal/vital organs. We conducted a quality of life (QOL) study for CCS who were treated with proton beam therapy (PBT).
MethodsWe included those patients treated with PBT to the brain, head, or neck and who were 15years old at the University of Tsukuba Hospital between 1983 and 2011. Clinical information was collected from medical records. Questionnaires including the Pediatric Quality of Life Inventory (PedsQL) 4.0 Generic Core Scales (which assess health-related quality of life) were sent to the families/patients.
ResultsSixty patients were included. Median age at treatment was 6.2years. The number of patients with status alive/dead/unknown was 32/24/4. Median follow-up period was 63.0months (range, 48-340months) for survivors. Questionnaires were sent to 25 families/patients and 19 were returned. PedsQL was assessed for 17 patients. Eleven of 32 living patients had at least one comorbidity grade 3/4. Average QOL score was above that for Japanese schoolchildren and adolescents. There was no correlation with comorbidity, and only longer time from treatment was correlated with a higher PedsQL score (P=0.006).
ConclusionCCS who were treated with multimodal treatment using PBT had a higher QOL score. Higher score was related to longer time since treatment, regardless of comorbidity.

Web of Science ® 被引用回数 : 6

リンク情報
DOI
https://doi.org/10.1111/ped.13323
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28503890
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000413949000001&DestApp=WOS_CPL
ID情報
  • DOI : 10.1111/ped.13323
  • ISSN : 1328-8067
  • eISSN : 1442-200X
  • PubMed ID : 28503890
  • Web of Science ID : WOS:000413949000001

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