論文

査読有り
2017年5月

Analysis of repeated proton beam therapy for patients with hepatocellular carcinoma

RADIOTHERAPY AND ONCOLOGY
  • Yoshiko Oshiro
  • ,
  • Masashi Mizumoto
  • ,
  • Toshiyuki Okumura
  • ,
  • Kuniaki Fukuda
  • ,
  • Nobuyoshi Fukumitsu
  • ,
  • Masato Abei
  • ,
  • Hitoshi Ishikawa
  • ,
  • Daichi Takizawa
  • ,
  • Hideyuki Sakurai

123
2
開始ページ
240
終了ページ
245
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.radonc.2017.03.004
出版者・発行元
ELSEVIER IRELAND LTD

Purpose: To evaluate the feasibility and efficacy of repeated proton beam therapy (PBT) and to analyze the dose-volume relationship.
Patients and methods: A retrospective analysis was performed in 83 patients who received definitive repeated PBT. Proton beams were delivered with expiratory gating. The numbers of treatment courses were 2, 3, and 4 in 68, 12, and 3 patients, respectively. MIM software was used for dose analysis.
Results: The planned median total dose was 70.5 GyE for all tumors and the median doses for the 1st, 2nd, 3rd and 4th treatments were 71.0, 70.0, 70.0, and 69.3 GyE, respectively. There was no severe acute toxicity, and no radiation-induced liver dysfunction (RILD) was observed. The median overall survival (OS) period from the first PBT was 61 months (95% CI: 50-71 months), and the 2- and 5-year OS rates were 87.5% (95%CI: 80.2-94.8%) and 49.4% (95%CI: 37.6-61.2%), respectively. The maximal delivered dose to the liver ranged from 66.7 to 248.1 GyE (mean: 124.93 GyE) and the mean liver dose ranged from 5.4 to 66.5 GyE (mean: 24.23 GyE).
Conclusion: Repeated PBT was well tolerated and safe, even though the liver doses in many patients deviated substantially from well-known critical levels for RILD. (C) 2017 Elsevier B.V. All rights reserved.

Web of Science ® 被引用回数 : 30

リンク情報
DOI
https://doi.org/10.1016/j.radonc.2017.03.004
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28366501
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000403028800011&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.radonc.2017.03.004
  • ISSN : 0167-8140
  • PubMed ID : 28366501
  • Web of Science ID : WOS:000403028800011

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