論文

査読有り
2017年3月1日

Long-term follow-up after proton beam therapy for pediatric tumors: a Japanese national survey

Cancer Science
  • Masashi Mizumoto
  • ,
  • Shigeyuki Murayama
  • ,
  • Tetsuo Akimoto
  • ,
  • Yusuke Demizu
  • ,
  • Takashi Fukushima
  • ,
  • Yuji Ishida
  • ,
  • Yoshiko Oshiro
  • ,
  • Haruko Numajiri
  • ,
  • Hiroshi Fuji
  • ,
  • Toshiyuki Okumura
  • ,
  • Hiroki Shirato
  • ,
  • Hideyuki Sakurai

108
3
開始ページ
444
終了ページ
447
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/cas.13140
出版者・発行元
Blackwell Publishing Ltd

Proton beam therapy (PBT) is a potential new alternative to treatment with photon radiotherapy that may reduce the risk of late toxicity and secondary cancer, especially for pediatric tumors. The goal of this study was to evaluate the long-term benefits of PBT in cancer survivors. A retrospective observational study of pediatric patients who received PBT was performed at four institutions in Japan. Of 343 patients, 62 were followed up for 5 or more years. These patients included 40 males and 22 females, and had a median age of 10 years (range: 0–19 years) at the time of treatment. The irradiation dose ranged from 10.8 to 81.2 GyE (median: 50.4 GyE). The median follow-up period was 8.1 years (5.0–31.2 years). The 5-, 10- and 20-year rates for grade 2 or higher late toxicities were 18%, 35% and 45%, respectively, and those for grade 3 or higher late toxicities were 6%, 17% and 17% respectively. Univariate analysis showed that the irradiated site (head and neck, brain) was significantly associated with late toxicities. No malignant secondary tumors occurred within the irradiated field. The 10- and 20-year cumulative rates for all secondary tumors, malignant secondary tumors, and malignant nonhematologic secondary tumors were 8% and 16%, 5% and 13%, and 3% and 11%, respectively. Our data indicate that PBT has the potential to reduce the risk of late mortality and secondary malignancy. Longer follow-up is needed to confirm the benefits of PBT for pediatric tumors.

リンク情報
DOI
https://doi.org/10.1111/cas.13140
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28004469
ID情報
  • DOI : 10.1111/cas.13140
  • ISSN : 1349-7006
  • ISSN : 1347-9032
  • PubMed ID : 28004469
  • SCOPUS ID : 85017116143

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