論文

査読有り
2015年5月1日

Tailor-made treatment combined with proton beam therapy for children with genitourinary/pelvic rhabdomyosarcoma

Reports of Practical Oncology and Radiotherapy
  • Hiroko Fukushima
  • ,
  • Takashi Fukushima
  • ,
  • Aiko Sakai
  • ,
  • Ryoko Suzuki
  • ,
  • Chie Kobayashi
  • ,
  • Yoshiko Oshiro
  • ,
  • Masashi Mizumoto
  • ,
  • Noriko Hoshino
  • ,
  • Chikashi Gotoh
  • ,
  • Yasuhisa Urita
  • ,
  • Hiroaki Komuro
  • ,
  • Michio Kaneko
  • ,
  • Noritoshi Sekido
  • ,
  • Kouji Masumoto
  • ,
  • Hideyuki Sakurai
  • ,
  • Ryo Sumazaki

20
3
開始ページ
217
終了ページ
222
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.rpor.2014.12.003
出版者・発行元
Urban and Partner

Background: Rhabdomyosarcoma (RMS) is one of the most common soft tissue sarcomas among children. Patients who developed genitourinary/pelvic rhabdomyosarcoma (GU/P-RMS) have a higher complication ratio and relatively poorer event free survival, with local therapy being very important. While proton beam therapy (PBT) is expected to reduce co-morbidity, especially for children, this lacks firm evidence and analysis. We analyzed GU/P-RMS children who had undergone multimodal therapy combined with PBT at a single institution. Method: We retrospectively reviewed charts of children with GU/P-RMS treated from January 2007 to May 2013 at the University of Tsukuba Hospital who had undergone multimodal therapy with PBT. Results: There were 5 children and their median age at diagnosis was 2.8 years (0.6-4.4 years). Primary sites were the bladder (2) and the prostate (3). All received neo-adjuvant chemotherapy and 3 underwent chemotherapy during PBT (Group Cx). All patients of Group Cx developed leukocytopenia (WBC &lt
1000/μL). The median dose of PBT was 47.7. GyE (41.4-50.4. GyE). All patients survived by their last hospital visit (median, 36 months). Conclusions: We analyzed multimodal treatment combined with PBT applied for GU/P-RMS. PBT was well tolerated and could be a plausible choice instead of photon therapy for this population.

リンク情報
DOI
https://doi.org/10.1016/j.rpor.2014.12.003
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25949226
ID情報
  • DOI : 10.1016/j.rpor.2014.12.003
  • ISSN : 1507-1367
  • PubMed ID : 25949226
  • SCOPUS ID : 84927800749

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