論文

査読有り
2015年8月

Proton beam therapy for pediatric ependymoma

PEDIATRICS INTERNATIONAL
  • Masashi Mizumoto
  • ,
  • Yoshiko Oshiro
  • ,
  • Daichi Takizawa
  • ,
  • Takashi Fukushima
  • ,
  • Hiroko Fukushima
  • ,
  • Tetsuya Yamamoto
  • ,
  • Ai Muroi
  • ,
  • Toshiyuki Okumura
  • ,
  • Koji Tsuboi
  • ,
  • Hideyuki Sakurai

57
4
開始ページ
567
終了ページ
571
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/ped.12624
出版者・発行元
WILEY-BLACKWELL

BackgroundThe aim of this study was to evaluate the efficacy of proton beam therapy for pediatric patients with ependymoma.
MethodsProton beam therapy was conducted for six patients (three boys and three girls; age, 2-6 years; median, 5 years) with ependymoma. The tumors were WHO grades 2 and 3 in two and four patients, respectively. All patients underwent surgery (subtotal and gross total resection in three patients each) and proton beam therapy at doses of 50.4-61.2 GyE (median, 56.7 GyE). The mean doses to normal brain tissue in proton beam therapy and photon radiotherapy were simulated using the same treatment planning computed tomography images.
ResultsAll patients completed the planned irradiation. The follow-up period was 13-44 months (median, 24.5 months) from completion of proton beam therapy and all patients were alive at the end of this period. Local recurrence in the treatment field occurred in one patient at 4 months after proton beam therapy at 50.4 GyE. Alopecia and mild dermatitis occurred in all patients, but there was no severe toxicity. One patient had a once-off seizure after proton beam therapy and alopecia persisted in another patient for 31 months, but no patients had difficulty with daily life. The simulation showed that proton beam therapy reduces the dose to normal brain tissue by approximately half compared with photon radiotherapy.
ConclusionsProton beam therapy for pediatric ependymoma is safe, does not have specific toxicities, and can reduce irradiation of normal brain tissue.

Web of Science ® 被引用回数 : 20

リンク情報
DOI
https://doi.org/10.1111/ped.12624
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25754294
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000360501500009&DestApp=WOS_CPL
ID情報
  • DOI : 10.1111/ped.12624
  • ISSN : 1328-8067
  • eISSN : 1442-200X
  • PubMed ID : 25754294
  • Web of Science ID : WOS:000360501500009

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