論文

査読有り
2015年1月

Comparison of dose-volume histograms between proton beam and X-ray conformal radiotherapy for locally advanced non-small-cell lung cancer

JOURNAL OF RADIATION RESEARCH
  • Toshiki Ohno
  • ,
  • Yoshiko Oshiro
  • ,
  • Masashi Mizumoto
  • ,
  • Haruko Numajiri
  • ,
  • Hitoshi Ishikawa
  • ,
  • Toshiyuki Okumura
  • ,
  • Toshiyuki Terunuma
  • ,
  • Takeji Sakae
  • ,
  • Hideyuki Sakurai

56
1
開始ページ
128
終了ページ
133
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1093/jrr/rru082
出版者・発行元
OXFORD UNIV PRESS

The purpose of this study was to compare the parameters of the dose-volume histogram (DVH) between proton beam therapy (PBT) and X-ray conformal radiotherapy (XCRT) for locally advanced non-small-cell lung cancer (NSCLC), according to the tumor conditions. A total of 35 patients having NSCLC treated with PBT were enrolled in this analysis. The numbers of TNM stage and lymph node status were IIB (n = 3), IIIA (n = 15) and IIIB (n = 17), and N0 (n = 2), N1 (n = 4), N2 (n = 17) and N3 (n = 12), respectively. Plans for XCRT were simulated based on the same CT, and the same clinical target volume (CTV) was used based on the actual PBT plan. The treatment dose was 74 Gy-equivalent dose (GyE) for the primary site and 66 GyE for positive lymph nodes. The parameters were then calculated according to the normal lung dose, and the irradiation volumes of the doses (Vx) were compared. We also evaluated the feasibility of both plans according to criteria: V5 >= 42%, V20 >= 25%, mean lung dose >= 20 Gy. The mean normal lung dose and V5 to V50 were significantly lower in PBT than in XCRT. The differences were greater with the more advanced nodal status and with the larger CTV. Furthermore, 45.7% of the X-ray plans were classified as inadequate according to the criteria, whereas 17.1% of the proton plans were considered unsuitable. The number of inadequate X-ray plans increased in cases with advanced nodal stage. This study indicated that some patients who cannot receive photon radiotherapy may be able to be treated using PBT.

Web of Science ® 被引用回数 : 10

リンク情報
DOI
https://doi.org/10.1093/jrr/rru082
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25368341
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000350245600014&DestApp=WOS_CPL
ID情報
  • DOI : 10.1093/jrr/rru082
  • ISSN : 0449-3060
  • eISSN : 1349-9157
  • PubMed ID : 25368341
  • Web of Science ID : WOS:000350245600014

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