論文

査読有り
2014年10月

Association between pretreatment retention rate of indocyanine green 15 min after administration and life prognosis in patients with HCC treated by proton beam therapy

RADIOTHERAPY AND ONCOLOGY
  • Masashi Mizumoto
  • ,
  • Yoshiko Oshiro
  • ,
  • Toshiyuki Okumura
  • ,
  • Kuniaki Fukuda
  • ,
  • Nobuyoshi Fukumitsu
  • ,
  • Masato Abei
  • ,
  • Hitoshi Ishikawa
  • ,
  • Kayoko Ohnishi
  • ,
  • Haruko Numajiri
  • ,
  • Koji Tsuboi
  • ,
  • Hideyuki Sakurai

113
1
開始ページ
54
終了ページ
59
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.radonc.2014.08.015
出版者・発行元
ELSEVIER IRELAND LTD

Purpose: The Child-Pugh score is often used to judge the outcome of radiotherapy for hepatocellular carcinoma (HCC). The retention rate of indocyanine green 15 min after administration (ICG R15) can also be used to predict prognosis after liver resection. We evaluated the utility of ICG R15 for prediction of outcomes after proton beam therapy (PBT) for HCC.
Methods and materials: A retrospective evaluation was performed in 250 patients who received PBT between 2002 and 2007. The patients (178 males and 72 females) had a median age of 71 years (range: 43-88). Child-Pugh categories were A (score 5-6), B (7-9), and C (10-15) in 197, 51, and 2 patients, respectively. ICG scores were 0-<10, 10-<20, 20-<30, 30-<40 and >= 40 in 27, 99, 59, 28 and 37 patients, respectively; including 26, 92, 45, 16 and 18 Child-Pugh A patients and 1, 8, 14, 11, and 17 Child-Pugh B patients, respectively. Survival times from the start of PBT were compared between Child-Pugh A and B patients, and among each ICG group.
Results: The median survival times were 61 months (95% CI: 50-72 months) in all patients, and 64 and 20 months in Child-Pugh A and B patients, respectively (p = 0.001), The 3-year survival rates were 72%, 72%, 75%, 63%, and 26% in patients with ICG scores of 0-<10, 10-<20, 20-<30, 30-<40, and >= 40 (p = 0.001); 70%, 75%, 77%, 65%, and 38% in these respective groups in Child-Pugh A patients (p = 0.02); and 100%, 57%, 67%, 36%, and 14% in Child-Pugh B patients (p = 0.173, not significant). Multivariate analysis showed that low ICG R15 and the absence of portal vein tumor thrombus were associated with good survival.
Conclusions: Pretreatment ICG R15 is a useful prognostic factor for prediction of outcome of PBT in HCC patients, especially in those with Child-Pugh A liver function. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

Web of Science ® 被引用回数 : 12

リンク情報
DOI
https://doi.org/10.1016/j.radonc.2014.08.015
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25248924
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000347604800009&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.radonc.2014.08.015
  • ISSN : 0167-8140
  • PubMed ID : 25248924
  • Web of Science ID : WOS:000347604800009

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