Papers

Peer-reviewed
Sep, 2014

High-dose concurrent chemo-proton therapy for Stage III NSCLC: preliminary results of a Phase II study

JOURNAL OF RADIATION RESEARCH
  • Yoshiko Oshiro
  • Toshiyuki Okumura
  • Koichi Kurishima
  • Shinsuke Homma
  • Masashi Mizumoto
  • Hitoshi Ishikawa
  • Masataka Onizuka
  • Mitsuaki Sakai
  • Yukinobu Goto
  • Nobuyuki Hizawa
  • Yukio Sato
  • Hideyuki Sakurai
  • Display all

Volume
55
Number
5
First page
959
Last page
965
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1093/jrr/rru034
Publisher
OXFORD UNIV PRESS

The aim of this report is to present the preliminary results of a Phase II study of high-dose (74 Gy RBE) proton beam therapy (PBT) with concurrent chemotherapy for unresectable locally advanced non-small-cell lung cancer (NSCLC). Patients were treated with PBT and chemotherapy with monthly cisplatin (on Day 1) and vinorelbine (on Days 1 and 8). The treatment doses were 74 Gy RBE for the primary site and 66 Gy RBE for the lymph nodes without elective lymph nodes. Adapted planning was made during the treatment. A total of 15 patients with Stage III NSCLC (IIIA: 4, IIIB: 11) were evaluated in this study. The median follow-up period was 21.7 months. None of the patients experienced Grade 4 or 5 non-hematologic toxicities. Acute pneumonitis was observed in three patients (Grade 1 in one, and Grade 3 in two), but Grade 3 pneumonitis was considered to be non-proton-related. Grade 3 acute esophagitis and dermatitis were observed in one and two patients, respectively. Severe (>= Grade 3) leukocytopenia, neutropenia and thrombocytopenia were observed in 10 patients, seven patients and one patient, respectively. Late radiation Grades 2 and 3 pneumonitis was observed in one patient each. Six patients (40%) experienced local recurrence at the primary site and were treated with 74 Gy RBE. Disease progression was observed in 11 patients. The mean survival time was 26.7 months. We concluded that high-dose PBT with concurrent chemotherapy is safe to use in the treatment of unresectable Stage III NSCLC.

Link information
DOI
https://doi.org/10.1093/jrr/rru034
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24864278
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000342223100015&DestApp=WOS_CPL
ID information
  • DOI : 10.1093/jrr/rru034
  • ISSN : 0449-3060
  • eISSN : 1349-9157
  • Pubmed ID : 24864278
  • Web of Science ID : WOS:000342223100015

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