論文

査読有り
2013年6月

Clinical results of proton beam therapy for advanced neuroblastoma

RADIATION ONCOLOGY
  • Yoshiko Oshiro
  • ,
  • Masashi Mizumoto
  • ,
  • Toshiyuki Okumura
  • ,
  • Shinji Sugahara
  • ,
  • Takashi Fukushima
  • ,
  • Hitoshi Ishikawa
  • ,
  • Tomohei Nakao
  • ,
  • Takayuki Hashimoto
  • ,
  • Koji Tsuboi
  • ,
  • Haruo Ohkawa
  • ,
  • Michio Kaneko
  • ,
  • Hideyuki Sakurai

8
開始ページ
142
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1186/1748-717X-8-142
出版者・発行元
BIOMED CENTRAL LTD

Purpose: To evaluate the efficacy of proton beam therapy (PBT) for pediatric patients with advanced neuroblastoma.
Methods: PBT was conducted at 21 sites in 14 patients with neuroblastoma from 1984 to 2010. Most patients were difficult to treat with photon radiotherapy. Two and 6 patients were classified into stages 3 and 4, respectively, and 6 patients had recurrent disease. Seven of the 8 patients who received PBT as the initial treatment were classified as the high risk group. Twelve patients had gross residual disease before PBT and 2 had undergone intraoperative radiotherapy before PBT. Five patients received PBT for multiple sites, including remote metastases. Photon radiotherapy was used in combination with PBT for 3 patients. The PBT doses ranged from 19.8 to 45.5 GyE (median: 30.6 GyE).
Results: Seven patients are alive with no evidence of disease, 1 is alive with disease progression, and 6 died due to the tumor. Recurrence in the treatment field was not observed and the 3-year locoregional control rate was 82%. Severe acute radiotoxicity was not observed, but 1 patient had narrowing of the aorta and asymptomatic vertebral compression fracture at 28 years after PBT, and hair loss was prolonged in one patient.
Conclusion: PBT may be a better alternative to photon radiotherapy for children with advanced neuroblastoma, and may be conducted safely for patients with neuroblastoma that is difficult to manage using photon beams.

Web of Science ® 被引用回数 : 24

リンク情報
DOI
https://doi.org/10.1186/1748-717X-8-142
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/23758770
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000320947600001&DestApp=WOS_CPL
ID情報
  • DOI : 10.1186/1748-717X-8-142
  • ISSN : 1748-717X
  • PubMed ID : 23758770
  • Web of Science ID : WOS:000320947600001

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