菅野直人 (Naoto Sugeno) - マイポータル

基本情報

所属: 東北大学講師

学位: 医学博士

J-GLOBAL ID: 201201086318383559
researchmap会員ID: B000222491

外部リンク: https://nrid.nii.ac.jp/ja/nrid/1000030509550/

αシヌクレインを中心に細胞を用いたパーキンソン病の基礎研究、特にエピジェネティクスに関わる研究を行っています。

主要な研究キーワード

もっとみる

研究分野

ライフサイエンス / 神経内科学 /

経歴

2024年10月 - 現在

東北大学, 病院（医科診療部門）脳神経内科, 講師
2021年4月 - 2024年9月

東北大学, 神経内科学, 助教
2016年10月 - 2021年3月

東北大学病院, 神経内科, 助教
2014年4月 - 2016年9月

テュービンゲン大学ハーティー脳神経疾患研究所, 客員研究員
2011年4月 - 2014年4月

東北大学病院, 神経内科, 助教

主要な論文

137

Dopa-responsive Rest Tremor Preceding Tachyphemia in Progressive Supranuclear Palsy: A Case Report.

Takuro Shiga, Shun Ishiyama, Naoto Sugeno, Kei Nozue, Kazuo Kakinuma, Masashi Aoki

Internal medicine (Tokyo, Japan) 2024年8月10日査読有り責任著者
Dysregulation of SNX1-retromer axis in pharmacogenetic models of Parkinson's disease.

Shun Yoshida, Takafumi Hasegawa, Takaaki Nakamura, Kazuki Sato, Naoto Sugeno, Shun Ishiyama, Kiyotoshi Sekiguchi, Muneshige Tobita, Atsushi Takeda, Masashi Aoki

Cell death discovery 10(1) 290-290 2024年6月17日査読有り
Reduced histone H3K4 trimethylation in oral mucosa of patients with DYT-KMT2B.

Naoto Sugeno, Satoko Kumada, Hirofumi Kashii, Jun Ikezawa, Toshitaka Kawarai, Takaaki Nakamura, Ako Miyata, Shun Ishiyama, Kazuki Sato, Shun Yoshida …

Parkinsonism & related disorders 124 107018-107018 2024年5月27日査読有り筆頭著者責任著者
Alpha-synuclein promotes PRMT5-mediated H4R3me2s histone methylation by interacting with the BAF complex.

Takaaki Nakamura, Naoto Sugeno, Takafumi Hasegawa, Kensho Ikeda, Shun Yoshida, Shun Ishiyama, Kazuki Sato, Atsushi Takeda, Masashi Aoki

The FEBS journal 2023年12月17日査読有り責任著者
Sortilin acts as an endocytic receptor for α-synuclein fibril.

Shun Ishiyama, Takafumi Hasegawa, Naoto Sugeno, Junpei Kobayashi, Shun Yoshida, Yasuo Miki, Koichi Wakabayashi, Mitsunori Fukuda, Yasushi Kawata, Takaaki Nakamura …

FASEB journal 37(7) e23017 2023年7月査読有り
Detection of Modified Histones from Oral Mucosa of a Patient with DYT-KMT2B Dystonia

Naoto Sugeno, Takafumi Hasegawa, Kazuhiro Haginoya, Takafumi Kubota, Kensuke Ikeda, Takaaki Nakamura, Shun Ishiyama, Kazuki Sato, Shun Yoshida, Eriko Koshimizu …

Molecular Syndromology 2023年6月26日査読有り筆頭著者責任著者
Unraveling the Complex Interplay between Alpha-Synuclein and Epigenetic Modification.

Naoto Sugeno, Takafumi Hasegawa

International journal of molecular sciences 24(7) 2023年4月2日筆頭著者責任著者
High prevalence of serum anti-NH2-terminal of α-enolase antibodies in patients with multiple system atrophy and corticobasal syndrome.

Akio Kikuchi, Makoto Yoneda, Takafumi Hasegawa, Akiko Matsunaga, Masamichi Ikawa, Takaaki Nakamura, Michinori Ezura, Toru Baba, Naoto Sugeno, Shun Ishiyama …

Journal of neurology 268(11) 4291-4295 2021年4月15日
18F-THK5351 Positron Emission Tomography Imaging in Neurodegenerative Tauopathies.

Michinori Ezura, Akio Kikuchi, Nobuyuki Okamura, Aiko Ishiki, Takafumi Hasegawa, Ryuichi Harada, Shoichi Watanuki, Yoshihito Funaki, Kotaro Hiraoka, Toru Baba …

Frontiers in aging neuroscience 13 761010-761010 2021年
Clinical characterization of patients with leucine-rich repeat kinase 2 genetic variants in Japan.

Yuanzhe Li, Aya Ikeda, Hiroyo Yoshino, Genko Oyama, Mitsuhiro Kitani, Kensuke Daida, Arisa Hayashida, Kotaro Ogaki, Kousuke Yoshida, Takashi Kimura …

Journal of human genetics 65(9) 771-781 2020年5月13日査読有り
Extracellular α-synuclein enters dopaminergic cells by modulating flotillin-1-assisted dopamine transporter endocytosis.

Kobayashi J, Hasegawa T, Sugeno N, Yoshida S, Akiyama T, Fujimori K, Hatakeyama H, Miki Y, Tomiyama A, Kawata Y …

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 33(9) 10240-10256 2019年9月査読有り
Parkinson's disease-linked DNAJC13 mutation aggravates alpha-synuclein-induced neurotoxicity through perturbation of endosomal trafficking.

Shun Yoshida, Takafumi Hasegawa, Mari Suzuki, Naoto Sugeno, Junpei Kobayashi, Morio Ueyama, Mitsunori Fukuda, Akemi Ido-Fujibayashi, Kiyotoshi Sekiguchi, Michinori Ezura …

Human molecular genetics 27(5) 823-836 2018年3月1日査読有り
DnaJ/Hsp40 family and Parkinson's disease

Takafumi Hasegawa, Shun Yoshida, Naoto Sugeno, Junpei Kobayashi, Masashi Aoki

Frontiers in Neuroscience 11(JAN) 743 2018年1月10日査読有り
Membrane Trafficking Illuminates a Path to Parkinson's Disease

Takafumi Hasegawa, Naoto Sugeno, Akio Kikuchi, Toru Baba, Masashi Aoki

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 242(1) 63-76 2017年5月査読有り
In vivo visualization of tau deposits in corticobasal syndrome by F-18-THK5351 PET

Akio Kikuchi, Nobuyuki Okamura, Takafumi Hasegawa, Ryuichi Harada, Shoichi Watanuki, Yoshihito Funaki, Kotaro Hiraoka, Toru Baba, Naoto Sugeno, Ryuji Oshima …

NEUROLOGY 87(22) 2309-2316 2016年11月査読有り
α-Synuclein enhances histone H3 lysine-9 dimethylation and H3K9me2-dependent transcriptional responses.

Sugeno N, Jäckel S, Voigt A, Wassouf Z, Schulze-Hentrich J, Kahle PJ

Sci Rep. 6 36328 2016年11月査読有り筆頭著者
ESCRT-0 dysfunction compromises autophagic degradation of protein aggregates and facilitates ER stress-mediated neurodegeneration via apoptotic and necroptotic pathways

Ryuji Oshima, Takafumi Hasegawa, Keiichi Tamai, Naoto Sugeno, Shun Yoshida, Junpei Kobayashi, Akio Kikuchi, Toru Baba, Akira Futatsugi, Ikuro Sato …

SCIENTIFIC REPORTS 6 24997 2016年4月査読有り
α-Synuclein oligomers pump it up!

Kahle PJ, Sugeno N, Skodras A

EMBO J. 34(19) 2385-2387 2015年10月査読有り
VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease.

Miura E, Hasegawa T, Konno M, Suzuki M, Sugeno N, Fujikake N, Geisler S, Tabuchi M, Oshima R, Kikuchi A …

Neurobiology of disease 71 1-13 2014年11月査読有り
186

Lys-63-linked Ubiquitination by E3 Ubiquitin Ligase Nedd4-1 Facilitates Endosomal Sequestration of Internalized α-Synuclein.

Sugeno N, Hasegawa T, Tanaka N, Fukuda M, Wakabayashi K, Oshima R, Konno M, Miura E, Kikuchi A, Baba T …

The Journal of biological chemistry 289(26) 18137-18151 2014年6月査読有り筆頭著者
Hypometabolism in the supplementary and anterior cingulate cortices is related to dysphagia in parkinson's disease: A cross-sectional and 3-year longitudinal cohort study

Akio Kikuchi, Toru Baba, Takafumi Hasegawa, Michiko Kobayashi, Naoto Sugeno, Masatoshi Konno, Emiko Miura, Yoshiyuki Hosokai, Toshiyuki Ishioka, Yoshiyuki Nishio …

BMJ Open 3(3) e002249 2013年査読有り
The AAA-ATPase VPS4 Regulates Extracellular Secretion and Lysosomal Targeting of alpha-Synuclein

Takafumi Hasegawa, Masatoshi Konno, Toru Baba, Naoto Sugeno, Akio Kikuchi, Michiko Kobayashi, Emiko Miura, Nobuyuki Tanaka, Keiichi Tamai, Katsutoshi Furukawa …

PLOS ONE 6(12) e29460 2011年12月査読有り
Role of TPPP/p25 on α-synuclein-mediated oligodendroglial degeneration and the protective effect of SIRT2 inhibition in a cellular model of multiple system atrophy

Takafumi Hasegawa, Toru Baba, Michiko Kobayashi, Masatoshi Konno, Naoto Sugeno, Akio Kikuchi, Yasuto Itoyama, Atsushi Takeda

Neurochemistry International 57(8) 857-866 2010年12月査読有り
In vivo visualization of alpha-synuclein deposition by carbon-11-labelled 2-[2-(2-dimethylaminothiazol-5-yl)ethenyl]-6-[2-(fluoro)ethoxy]benzoxazole positron emission tomography in multiple system atrophy

Akio Kikuchi, Atsushi Takeda, Nobuyuki Okamura, Manabu Tashiro, Takafumi Hasegawa, Shozo Furumoto, Michiko Kobayashi, Naoto Sugeno, Toru Baba, Yasuo Miki …

BRAIN 133(6) 1772-1778 2010年6月査読有り
Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death

Naoto Sugeno, Atsushi Takeda, Takafumi Hasegawa, Michiko Kobayashi, Akio Kikuchi, Fumiaki Mori, Koichi Wakabayashi, Yasuto Itoyama

JOURNAL OF BIOLOGICAL CHEMISTRY 283(34) 23179-23188 2008年8月査読有り筆頭著者