Futoshi Suizu

Profile Information

Affiliation: Associate Professor, Faculty of Medicine School of Medicine, Kagawa University

Degree: PhD(Hiroshima University)

Other name(s) (e.g. nickname): Futoshi Suizu
J-GLOBAL ID: 201301074593905734
researchmap Member ID: B000227241

External link: https://www.med.kagawa-u.ac.jp/~ichibyou/en/

Research Interests

Research Areas

Research History

Jul, 2021 - Present

Associate Professor, Faculty of Medicine School of Medicine, Kagawa University
Sep, 2016 - Jun, 2021

Associate Professor, Institute for Genetic Medicine, Hokkaido University
Aug, 2019 - Aug, 2020

Visiting Research Fellow of Fund for the Promotion of Joint International Research, Department of Medicine, Beth Israel Deaconess Medical Center (BIDMC)
Mar, 2013 - Aug, 2016

Lecturer, Institute for Genetic Medicine, Hokkaido University
Apr, 2007 - Feb, 2013

Assistant Professor, Institute for Genetic Medicine, Hokkaido University
Apr, 2006 - Mar, 2007

Assistant Professor, Institute for Genetic Medicine, Hokkaido University
Oct, 2002 - Mar, 2006

Postdoctoral Research Fellow, Department of Medicine, Beth Israel Deaconess Medical Center(BIDMC)

Education

Apr, 1995 - Sep, 2002

Department of Biological Science, Graduate School of Science, Hiroshima University
Apr, 1991 - Mar, 1995

Kochi University

Committee Memberships

Oct, 2016 - Present

評議員, 北海道医学会

Papers

Conformation-Dependent Reversible Interaction of Ca²⁺/Calmodulin-Dependent Protein Kinase Kinase with an Inhibitor, TIM-063

Satomi Ohtsuka, Taisei Okumura, Yuna Τabuchi, Tomoyuki Miyagawa, Naoki Kanayama, Masaki Magari, Naoya Hatano, Hiroyuki Sakagami, Futoshi Suizu, Teruhiko Ishikawa, Hiroshi Tokumitsu

Biochemistry, 61(7) 545-553, Apr, 2022 Peer-reviewed
Telomere length was associated with grade and pathological features of meningioma

Keiko Yamakawa, Yuri Mukai, Juanjuan Ye, Mariko Muto-Ishizuka, Masumi Ito, Misa Tanimoto, Futoshi Suizu, Kenichiro Asano, Akira Kurose, Yoko Matsuda

Scientific Reports, 12(1) 6143-6143, Apr, 2022 Peer-reviewed
Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy

Kazuhiro Koikawa, Shin Kibe, Futoshi Suizu, Nobufumi Sekino, Nami Kim, Theresa D Manz, Benika J Pinch, Dipikaa Akshinthala, Ana Verma, Giorgio Gaglia, Yutaka Nezu, Shizhong Ke, Chenxi Qiu, Kenoki Ohuchida, Yoshinao Oda, Tae Ho Lee, Babara Wegiel, John G Clohessy, Nir London, Sandro Santagata, Gerburg M Wulf, Manuel Hidalgo, Senthil K Muthuswamy, Masafumi Nakamura, Nathanael S Gray, Xiao Zhen Zhou, Kun Ping Lu

Cell, 184(18) 4753-4771, Sep, 2021 Peer-reviewed
原生生物 4(1) 5-14 2021年8月

4(1) 5-14, Aug, 2021 Peer-reviewed
Phosphorylation-Dependent Peptidyl-Prolyl Cis/Trans Isomerase PIN1.

Jormay Lim, Tae Ho Lee, Futoshi Suizu

Front Cell Dev Biol, 8 620418, Nov, 2020 Peer-reviewedInvitedLast author
LAMP3 induces apoptosis and autoantigen release in Sjögren's syndrome patients.

Tsutomu Tanaka, Blake M Warner, Toshio Odani, Youngmi Ji, Ying-Qian Mo, Hiroyuki Nakamura, Shyh-Ing Jang, Hongen Yin, Drew G Michael, Noriyuki Hirata, Futoshi Suizu, Satoko Ishigaki, Fabiola Reis Oliveira, Ana Carolina F Motta, Alfredo Ribeiro-Silva, Eduardo M Rocha, Tatsuya Atsumi, Masayuki Noguchi, John A Chiorini

Scientific Reports, 10(1) 15169-15169, Sep 16, 2020 Peer-reviewed
Autophagy as a modulator of cell death machinery.

Masayuki Noguchi, Noriyuki Hirata, Tsutomu Tanaka, Futoshi Suizu, Hiroshi Nakajima, John A Chiorini

Cell Death & Disease, 11(7) 517-517, Jul 8, 2020 Peer-reviewed
Immunomodulatory Mechanism of Acyclic Nucleoside Phosphates in Treatment of Hepatitis B Virus Infection.

Kazumoto Murata, Senko Tsukuda, Futoshi Suizu, Akihiro Kimura, Masaya Sugiyama, Koichi Watashi, Masayuki Noguchi, Masashi Mizokami

Hepatology (Baltimore, Md.), 71(5) 1533-1545, May, 2020 Peer-reviewed
Development and characterization of novel molecular probes for Ca²⁺/calmodulin-dependent protein kinase kinase, derived from STO-609.

Satomi Ohtsuka, Yui Ozeki, Moeno Fujiwara, Tomoyuki Miyagawa, Naoki Kanayama, Masaki Magari, Naoya Hatano, Futoshi Suizu, Teruhiko Ishikawa, Hiroshi Tokumitsu

Biochemistry, 59(17) 1701-1710, Apr 16, 2020 Peer-reviewed
Tolerance of Colpoda cucullus Nag-1 Resting Cysts and Presumed Structure for Protection against UV Light

Shinji Yamane, Maho Watanabe, Ryoji Funadani, Ryutaro Miyazaki, Yuya Hasegawa, Mikihiko Arikawa, Futoshi Suizu, Kou Matsuoka, Tatsuomi Matsuoka

Acta Protozoologica, 59 55-60, Mar, 2020 Peer-reviewed
Antifreeze Water-Rich Dormant Cysts of the Terrestrial Ciliate Colpoda cucullusNag-1 at −65 ˚C: Possible Involvement of Ultra-Antifreeze Polysaccharides

Tatsuomi Matsuoka, Yoichiro Sogame, Rikiya Nakamura, Yuya Hasegawa, Mikihiko Arikawa, Futoshi Suizu

Acta Protozoologica, 59 141-147, 2020 Peer-reviewedCorresponding author
Tolerance of Colpoda cucullus Nag-1 wet resting cysts to extreme pH (pH 1 and 13): Implications of less permeability of the cyst membrane to H+ and OH-

Rikiya Nakamura, Yoichiro Sogame, Mikihiko Arikawa, Futoshi Suizu, Tatsuomi Matsuoka

The Journal of Protozoology Research, 30 38-46, 2020 Peer-reviewedCorresponding author
Effects of Chlorophyllin on Encystment Suppression and Excystment Induction in Colpoda Cucullus NAG-1: An Implication of Chlorophyllin Receptor.

Masaya Morishita, Futoshi Suizu, Mikihiko Arikawa, Tatsuomi Matsuoka

Asian Journal of Microbiology, Biotechnology and Environmental Science, 22(4) 573-578, 2020 Peer-reviewedCorresponding author
Analysis of Water-Soluble Proteins by Two-Dimensional Electrophoresis in the Encystment Process of Colpoda cucullus Nag-1 and Cytoskeletal Dynamics

Yoichiro Sogame, Katsuhiko Kojima, Toshikazu Takeshita, Shiho Kikuchi, Yuto Shimada, Rikiya Nakamura, Mikihiko Arikawa, Seiji Miyata, Eiji Kinoshita, Futoshi Suizu, Tatsuomi Matsuoka

Acta Protozoologica, 59(3-4) 107-120, 2020 Peer-reviewed
Identification of RNA aptamer which specifically interacts with PtdIns(3)P

Thoria Donia, Bala Jyoti, Futoshi Suizu, Noriyuki Hirata, Tsutomu Tanaka, Satoko Ishigaki, Pranzatelli Thomas J F, Junko Nio-Kobayashi, Toshihiko Iwanaga, John A Chiorini, Masayuki Noguchi

Biochemical and Biophysical Research Communications (BBRC), 517(1) 146-154, Sep, 2019 Peer-reviewed
Functional characterization of lysosomal interaction of Akt with VRK2

Noriyuki Hirata, Futoshi Suizu, Mami Matsuda-Lennikov, Tsutomu Tanaka, Tatsuma Edamura, Satoko Ishigaki, Thoria Donia, Pathrapol Lithanatudom, Chikashi Obuse, Toshihiko Iwanaga, Masayuki Noguchi

Oncogene, doi: 10.1038/s41388-018-0330-0 1-20, Jun 5, 2018 Peer-reviewed
AKT keeps the beat in CLOCK’s circadian rhythm

Masayuki Noguchi, Noriyuki Hirata, Futoshi Suizu

Journal of Biological Chemistry, 293(23) 9137-9138, 2018 Peer-reviewed
EZH2 inhibition suppresses endometrial cancer progression via miR-361/Twist axis

Kei Ihira, Peixin Dong, Ying Xiong, Hidemichi Watari, Yosuke Konno, Sharon J. B. Hanley, Masayuki Noguchi, Noriyuki Hirata, Futoshi Suizu, Takahiro Yamada, Masataka Kudo, Noriaki Sakuragi

Oncotarget, 8(8) 13509-13520, Feb, 2017 Peer-reviewed
Photoresponse in the ciliated protozoan Colpoda cucullus

Noriyuki Kawano, Ryoji Funadani, Mikihiko Arikawa, Tetsuo Harada, Futoshi Suizu, Kou Matsuoka, Tatsuomi Matsuoka

Acta Protozoologica, 56(1) 1-7, 2017 Peer-reviewed
Morphogenetic and molecular analyses of cyst wall components in the ciliated protozoan Colpoda cucullus Nag-1

Ryoji Funadani, Yoichiro Sogame, Katsuhiko Kojima, Toshikazu Takeshita, Keisuke Yamamoto, Tomoya Tsujizono, Futoshi Suizu, Seiji Miyata, Ken-Ichi Yagyu, Tomohiko Suzuki, Mikihiko Arikawa, Tatsuomi Matsuoka

FEMS Microbiology Letters, 363(18), Sep, 2016 Peer-reviewed

Misc.

繊毛虫コルポーダColpoda cucullusにおける休眠シスト壁形成に関する研究

舟谷亮二, 十亀陽一郎, 小嶋克彦, 竹下敏一, 山本圭祐, 辻囿智哉, 水津太, 宮田清司, 矢生健一, 鈴木知彦, 有川幹彦, 松岡達臣

日本原生生物学会大会講演要旨集, 49th 33, Oct 5, 2016
Lysosomal interaction of Akt with Phafin2: A critical step in the induction of autophagy

Masayuki Noguchi, Futoshi Suizu, Mami Lennikov-Matsuda, Bala Jyoti, Yusuke Ohba, Noriyuki Hirata

MOLECULAR CANCER THERAPEUTICS, 14(7), Jul, 2015
プロトオンコジーンTCL1bはAktの活性化補助因子であり,in vivoでの腫瘍化を示す。

橋本学, 水津太, 徳山宣, 野口寛子, 松田真実, 平田徳幸, 永峰賢, 田中伸哉, 野口昌幸

日本分子生物学会年会プログラム・要旨集(Web), 35th WEB ONLY 3P-0454, 2012
Akt活性を修飾する新しい分子標的の探索

水津太

上原記念生命科学財団研究報告集(CD-ROM), 23 ROMBUNNO.112, 2009
細胞死と増殖を介した生体ホメオスターシス制御の破綻と疾病

野口昌幸, 成田真澄, 木脇圭一, 水津太

適応医学, 11(1) 19, May 20, 2007
AKTの活性化と癌

野口昌幸, 水津太

日本癌学会学術総会記事, 65th 432, Aug 28, 2006
Pin1による中心体複製制御と癌化

水津太, 梁明秀, WULF Gerburg, LIM Jormay, 野口昌幸, LU Kun Ping

日本癌学会学術総会記事, 65th 120, Aug 28, 2006
新規ミオシン調節軽鎖キナーゼとして同定されたCaM‐KIの解析

水津太, 福田康朗, 上田こずえ, 菊池麻子, 村田(堀)麻希, 徳光浩, 細谷浩史

生化学, 73(8) 812, Aug 25, 2001
Activation of actin-activated MgATPase activity of myosin II by phosphorylation with MAPK-activated protein kinase-1

F Suizu, K Ueda, T Iwasaki, M Murata-Hori, H Hosoya

MOLECULAR BIOLOGY OF THE CELL, 11 542A-542A, Dec, 2000
MAPKAPK‐1によるミオシンII調節軽鎖(MRLC)のリン酸化とミオシンATPase活性の制御

水津太, 上田こずえ, 岩崎隆宏, 村田(堀)麻希, 細谷浩史

日本細胞生物学会大会講演要旨集, 53rd 61, 2000
動物細胞の分裂時に形成される収縮板とミオシンの二重リン酸化

細谷浩史, 上田こずえ, 達家雅明, 水津太, 岩崎隆宏, 菊地麻子, 村田(堀)麻希

日本分子生物学会年会プログラム・講演要旨集, 22nd 638, Nov 22, 1999
ZIP kinase identified as a novel myosin regulatory light chain kinase in HeLa cells.

M Murata-Hori, F Suizu, T Iwasaki, A Kikuchi, H Hosoya

MOLECULAR BIOLOGY OF THE CELL, 10 166A-166A, Nov, 1999
ZIP kinase identified as a novel myosin regulatory light chain kinase in HeLa cells(Cell Biology and Morphology)(Proceedings of the Seventieth Annual Meeting of the Zoological Society of Japan) :

Muarta-Hori M., Suizu F., Iwasaki T., Kikuchi A., Fukuta Y., Hosoya H.

Zoological science, 16 32-32, 1999

Books and Other Publications

Latest cancer pharmacotherapy-latest knowledge of cancer drug therapy-

Masayuki Noguchi, Masahiro Sakaitani, Futoshi Suizu (Role: Joint author, Mechanism of action of cancer drug treatment Molecular target therapeutic drug Low molecular weight compound Other serine / threonine kinase inhibitors)

Japan clinical practice volume 72 extra edition 2 latest cancer pharmacotherapy, Feb, 2014
Regulation of Akt by phosphorylation of distinct threonine and serine residues Threonine: Structure, Biosynthesis and Functions

Noguchi M, Suizu F

Nova Science Publishers, New York. USA, 2011
構造と機能の解析による遺伝子情報の制御法の開発

野口昌幸, 水津太 (Role: Contributor, バイオとナノの融合II 新生命科学の応用)

北海道大学出版会, 2006

Professional Memberships

Dec, 2020 - Present

THE GENETICS SOCIETY OF JAPAN
Oct, 2020 - Present

Japan Society for Nucleic Acid Medicine
Oct, 2020 - Present

The Japanese Pharmacological Society
Apr, 2018 - Present

THE JAPANESE CONFERENCE ON THE BIOCHEMISTRY OF LIPIDS
Sep, 2016 - Present

THE HOKKAIDO MEDICAL SOCIETY
Sep, 2006 - Present

THE JAPANESE CANCER ASSOCIATION
Apr, 2000 - Present

THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
Apr, 2000 - Present

THE JAPANESE BIOCHEMICAL SOCIETY

Research Projects

がん細胞オートファジーを標的とした核酸医薬の創出と応用

「シーズA」事業, 国立研究開発法人日本医療研究開発機構（AMED）, Apr, 2021 - Mar, 2022
Transcriptional regulatory mechanisms by ciliary proteins

Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Futoshi Suizu
Regulatory dynamics of cellular membrane phospholipids by Pin1-Akt related factors

Fund for the Promotion of Joint International Research (Fostering Joint International Research (A)), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2021

Futoshi Suizu
膜リン脂質特異的な核酸医薬の創出とその応用に関する研究

革新的先端研究開発支援事業PRIME 画期的医薬品等の創出をめざす脂質の生理活性と機能の解明, 国立研究開発法人日本医療研究開発機構（AMED）, Oct, 2017 - Mar, 2021

水津太
Aktによる繊毛タンパクInversinの制御機構の解明

科学研究費補助金基盤研究(C), 文部科学省, Apr, 2016 - Mar, 2019

水津太
細胞極性制御の分子基盤におけるAktの機能解析

科学研究費補助金基盤研究(C), 文部科学省, Apr, 2013 - Mar, 2016

水津太
新規Akt特異的ユビキチンリガーゼによる細胞死制御機構の解明

科学研究費補助金基盤研究(B), 文部科学省, Apr, 2010 - Mar, 2013

野口昌幸
Akt修飾因子TTC3によるPI3K-Aktシグナル伝達制御機構の解明

科学研究費補助金若手研究(B), 文部科学省, Apr, 2010 - Mar, 2013

水津太
Identification of novel AKT regulating molecules.

Grants-in-Aid for Scientific Research(若手研究(B)), Ministry of Education, Culture, Sports, Science and Technology, Apr, 2007 - Mar, 2010

Futoshi SUIZU

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