Sunami Tomoko

Profile Information

Affiliation: Senior Researcher, Molecular Modelling and Simulation Team, Institute for Quantum Life Science, National Institutes for Quantum and Radiological Science and Technology

J-GLOBAL ID: 201801016711728890
researchmap Member ID: B000322487

Research Areas

Life sciences / Biophysics /

Research History

Apr, 2009 - Present

Institute for Quantum Life Science, National Institutes for Quantum Science and Technology
Apr, 2002 - Mar, 2009

Banyu Pharmaceutical Co.,LTD

Education

Apr, 1997 - Mar, 2002

Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
Apr, 1994 - Mar, 1997

School of Bioscience and Biotechnology, Tokyo Institute of Technology

Papers

Structural basis for designing an array of engrailed homeodomains

Tomoko Sunami, Yu Hirano, Taro Tamada, Hidetoshi Kono

Acta Crystallographica Section D Structural Biology, 76(9) 824-833, Sep 1, 2020 Peer-reviewedLead author
Neutron crystallography of copper amine oxidase reveals keto/enolate interconversion of the quinone cofactor and unusual proton sharing.

Takeshi Murakawa, Kazuo Kurihara, Mitsuo Shoji, Chie Shibazaki, Tomoko Sunami, Taro Tamada, Naomine Yano, Taro Yamada, Katsuhiro Kusaka, Mamoru Suzuki …

Proceedings of the National Academy of Sciences of the United States of America, 117(20) 10818-10824, May 5, 2020 Peer-reviewed
Balance between DNA‐binding affinity and specificity enables selective recognition of longer target sequences in vivo

Tomoko Sunami, Hidetoshi Kono

Protein Science, 28(9) 1630-1639, Sep, 2019 Peer-reviewed
Hydration Structures of the Human Protein Kinase CK2α Clarified by Joint Neutron and X-ray Crystallography.

Shibazaki C, Arai S, Shimizu R, Saeki M, Kinoshita T, Ostermann A, Schrader TE, Kurosaki Y, Sunami T, Kuroki R …

Journal of molecular biology, 430(24) 5094-5104, Oct, 2018 Peer-reviewed
DNA conformational transitions inferred from re-evaluation of m vertical bar F-o vertical bar - D vertical bar F-c vertical bar electron-density maps

Tomoko Sunami, Toshiyuki Chatake, Hidetoshi Kono

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 73(Pt 7) 600-608, Jul, 2017 Peer-reviewed
3P088 Designing a new artificial transcription factor based on engrailed homeodomain(01F. Protein: Engineering,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014))

Sunami Tomoko, Kono Hidetoshi

Seibutsu Butsuri, 54(1) S263, 2014
High-resolution crystal structure of copper amine oxidase from Arthrobacter globiformis: assignment of bound diatomic molecules as O-2

Takeshi Murakawa, Hideyuki Hayashi, Tomoko Sunami, Kazuo Kurihara, Taro Tamada, Ryota Kuroki, Mamoru Suzuki, Katsuyuki Tanizawa, Toshihide Okajima

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 69(Pt 12) 2483-2494, Dec, 2013 Peer-reviewed
Direct interactions between Z-DNA and alkaline earth cations, discovered in the presence of high concentrations of MgCl2 and CaCl2

Toshiyuki Chatake, Tomoko Sunami

JOURNAL OF INORGANIC BIOCHEMISTRY, 124 15-25, Jul, 2013 Peer-reviewed
Local Conformational Changes in the DNA Interfaces of Proteins

Tomoko Sunami, Hidetoshi Kono

PLOS ONE, 8(2) e56080, Feb, 2013 Peer-reviewed
1B1522 Local conformational changes of proteins in DNA interfaces(Proteins: Structure & Function I,Oral Presentation,The 50th Annual Meeting of the Biophysical Society of Japan)

Sunami Tomoko, Kono Hidetoshi

Seibutsu Butsuri, 52 S22, 2012
Structural Basis of Human p70 Ribosomal S6 Kinase-1 Regulation by Activation Loop Phosphorylation

Tomoko Sunami, Noel Byrne, Ronald E. Diehl, Kaoru Funabashi, Dawn L. Hall, Mari Ikuta, Sangita B. Patel, Jennifer M. Shipman, Robert F. Smith, Ikuko Takahashi …

JOURNAL OF BIOLOGICAL CHEMISTRY, 285(7) 4587-4594, Feb, 2010 Peer-reviewed
Insights into the structures of DNA damaged by hydroxyl radical: Crystal structures of DNA duplexes containing 5-formyluracil

Masaru Tsunoda, Takeshi Sakaue, Satoko Naito, Tomoko Sunami, Naoko Abe, Yoshihito Ueno, Akira Matsuda, Akio Takénaka

Journal of Nucleic Acids, 2010 107289, 2010 Peer-reviewed
The structure of a d(gcGAACgc) duplex containing two consecutive bulged A residues in both strands suggests a molecular switch

Jiro Kondo, Tomoko Sunami, Akio Takenaka

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 63(Pt 6) 673-681, Jun, 2007 Peer-reviewed
DNA octaplex formation with an I-motif of water-mediated A-quartets: Reinterpretation of the crystal structure of d(gcGAAAgc)

Yoshiteru Sato, Kenta Mitomi, Tomoko Sunami, Jiro Kondo, Akio Takenaka

JOURNAL OF BIOCHEMISTRY, 140(6) 759-762, Dec, 2006 Peer-reviewed
Octaplex formation of d(GCGAAAGC) with the double A-quartet.

Mitomi K, Kondo J, Adachi W, Umeda S, Fujita K, Sunami T, Takénaka A

Nucleic acids symposium series (2004), (49) 71-72, 2005 Peer-reviewed
Crystallization and preliminary X-ray analyses of the active and the inactive forms of family GH-8 chitosanase with subclass II specificity from Bacillus sp strain K17

Y Sakihama, W Adachi, S Shimizu, T Sunami, T Fukazawa, M Suzuki, R Yatsunami, S Nakamura, A Takenaka

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 60 2081-2083, Nov, 2004 Peer-reviewed
Crystal structure of family GH-8 chitosanase with subclass II specificity from Bacillus sp K17

W Adachi, Y Sakihama, S Shimizu, T Sunami, T Fukazawa, M Suzuki, R Yatsunami, S Nakamura, A Takenaka

JOURNAL OF MOLECULAR BIOLOGY, 343(3) 785-795, Oct, 2004 Peer-reviewed
Structures of d(GCGAAGC) and d(GCGAAAGC) (tetragonal form): a switching of partners of the sheared G center dot A pairs to form a functional G center dot AxA center dot G crossing

T Sunami, J Kondo, Hirao, I, K Watanabe, K Miura, A Takenaka

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 60 422-431, Mar, 2004 Peer-reviewed
Crystal structures of a DNA octaplex with I-motif of G-quartets and its splitting into two quadruplexes suggest of a folding mechanism of eight tandem repeats

Jiro Kondo, Wataru Adachi, Shun-Ichi Umeda, Tomoko Sunami, Akio Takénaka

Nucleic Acids Research, 32(8) 2541-2549, 2004 Peer-reviewed
X-ray analyses of d(GCGAXAGC) containing G and T at X: the base-intercalated duplex is still stable even in point mutants at the fifth residue

J Kondo, S Umeda, K Fujita, T Sunami, A Takenaka

JOURNAL OF SYNCHROTRON RADIATION, 11 117-120, Jan, 2004 Peer-reviewed

Misc.

The crystal structure of subclass II chitosanase from Bacillus sp. K17 and the functional diversity in the family-8 glycosidases

SHIMIZU Shinji, ADACHI Wataru, SUNAMI Tomoko, HOSSAIN Tofazzal, SUZUKI Mamie, FUKAZAWA Tetsuya, SAKIHAMA Yuri, YATSUNAMI Rie, NAKAMURA Satoshi, TAKENAKA Akio

9(2) 92-93, Jun 1, 2003

Professional Memberships

Research Projects

中性子線を用いたタンパク質の動的な水和水の解析

科学研究費助成事業挑戦的研究(萌芽), 挑戦的研究(萌芽), 日本学術振興会, Jun, 2022 - Mar, 2025

茶竹俊行, 藤原悟, 田中伊知朗, 角南智子
分子夾雑環境におけるヌクレオソームDNAの塩基配列依存的アンラッピングの解析

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

角南智子
Improvement of sequence specificity of DNA-binding protein using computational and experimental approaches

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

KONO HIDETOSHI, SUNAMI Tomoko
Designing a highly specific transcription factor

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2016

Sunami Tomoko
Improvement of predictions of transcription factor binding sites using sequence dependent deformability of DNA

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2011 - 2012

SUNAMI Tomoko

Industrial Property Rights

国際特許番号WO10111056 Novel aminopyridine derivatives having Aurora A selective inhibitory action

H. Binch, M. Hashimoto, M. Mortimore, M. Ohkubo, T. Sunami
国際特許番号WO10111057 Novel aminopyridine derivatives having Aurora A selective inhibitory action

T. Iwama, N. Kawanishi, M. Mortimore, M. Ohkubo, T. Sunami
国際特許番号WO10111050 Novel aminopyridine derivatives having Aurora A selective inhibitory action

H. Binch, M. Hashimoto, T. Iwama, N. Kawanishi, M. Mortimore, M. Ohkubo, T. Sunami
米国特許番号US20090317850 Crystal structure of human 70KD ribosomal protein S6 kinase 1 kinase domain

T. Sunami, M. Machida, S. Munshi, S. Sharma

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