論文

査読有り
2020年9月1日

Sustained laryngeal transient receptor potential vanilloid 1 activation inhibits mechanically induced swallowing in anesthetized rats

American Journal of Physiology-Gastrointestinal and Liver Physiology
  • Midori Yoshihara
  • ,
  • Takanori Tsujimura
  • ,
  • Taku Suzuki
  • ,
  • Kouta Nagoya
  • ,
  • Naru Shiraishi
  • ,
  • Jin Magara
  • ,
  • Miho Terunuma
  • ,
  • Makoto Inoue

319
3
開始ページ
G412
終了ページ
G419
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.1152/ajpgi.00082.2020
出版者・発行元
American Physiological Society

Although a transient receptor potential vanilloid 1 (TRPV1) inhibitor or TRPV1-expressed neuronal inhibitor significantly inhibited HCl/capsaicin-evoked swallowing, air flow-induced swallowing was not affected. The number of air flow-induced swallows was significantly reduced within 60 min of TRPV1 activation. Evans blue dye concentration in the larynx increased 60 min after capsaicin application. TPRV1 activation not only desensitizes TRPV1 but also inactivates mechanoreceptors caused by increases in vascular permeability and edema.

リンク情報
DOI
https://doi.org/10.1152/ajpgi.00082.2020
URL
https://journals.physiology.org/doi/pdf/10.1152/ajpgi.00082.2020
ID情報
  • DOI : 10.1152/ajpgi.00082.2020
  • ISSN : 0193-1857
  • eISSN : 1522-1547

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