2020年9月1日
Sustained laryngeal transient receptor potential vanilloid 1 activation inhibits mechanically induced swallowing in anesthetized rats
American Journal of Physiology-Gastrointestinal and Liver Physiology
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- 巻
- 319
- 号
- 3
- 開始ページ
- G412
- 終了ページ
- G419
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1152/ajpgi.00082.2020
- 出版者・発行元
- American Physiological Society
Although a transient receptor potential vanilloid 1 (TRPV1) inhibitor or TRPV1-expressed neuronal inhibitor significantly inhibited HCl/capsaicin-evoked swallowing, air flow-induced swallowing was not affected. The number of air flow-induced swallows was significantly reduced within 60 min of TRPV1 activation. Evans blue dye concentration in the larynx increased 60 min after capsaicin application. TPRV1 activation not only desensitizes TRPV1 but also inactivates mechanoreceptors caused by increases in vascular permeability and edema.
- リンク情報
- ID情報
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- DOI : 10.1152/ajpgi.00082.2020
- ISSN : 0193-1857
- eISSN : 1522-1547