Shinya Yuge

Profile Information

Affiliation: Nippon Medical School

Degree: Ph. D.(The University of Tokyo)

researchmap Member ID: B000312269

Research Interests

Research Areas

Research History

Oct, 2023 - Present

Faculty of Dentistry, Division of Biology in Liberal Arts Department, Tokyo Medical and Dental University
Apr, 2016 - Present

Assistant Professor, Dept. Mol. Pathophysiol., Institute for Advanced Medical Sciences, Nippon Medical School
May, 2013 - Mar, 2016

Research Associate, Dept. Cell. Biol., National Cerebral and Cardioavascular Center Research Institute
Jan, 2009 - Apr, 2013

Research Associate, Div. Fish Wildlife, Dept. Agr. Nat. Resrc., Michigan State University
Oct, 2006 - Dec, 2008

Postdoctoral Fellow, Radiopharmaceutical Inst., School of Medicine, University of Missouri at Columbia
Apr, 2003 - Mar, 2006

Research Fellowship DC1, Japan Society for the Promotion of Science

Awards

Papers

Novel regulatory mechanisms underlying angiogenesis during wound healing revealed by fluorescence-based live-imaging in zebrafish.

Shinya Yuge, Tomohiro Ishii, Chikage Noishiki, Shigetomo Fukuhara

The Journal of Biochemistry, 174(1) 5-12, Mar 17, 2023 Peer-reviewedInvitedLead author
Mechanical loading of intraluminal pressure mediates wound angiogenesis by regulating the TOCA family of F-BAR proteins.

Shinya Yuge, Koichi Nishiyama, Yuichiro Arima, Yasuyuki Hanada, Eri Oguri-Nakamura, Sanshiro Hanada, Tomohiro Ishii, Yuki Wakayama, Urara Hasegawa, Kazuya Tsujita …

Nature communications, 13(1) 2594-2594, May 12, 2022 Peer-reviewedLead author
Blood Flow Regulates Glomerular Capillary Formation in Zebrafish Pronephros.

Yusuke Nishimura, Tomohiro Ishii, Koji Ando, Shinya Yuge, Hiroyuki Nakajima, Weibin Zhou, Naoki Mochizuki, Shigetomo Fukuhara

Kidney360, 3(4) 700-713, Apr 28, 2022 Peer-reviewed
Valves Are a Conserved Feature of the Zebrafish Lymphatic System.

Shin M, Nozaki T, Idrizi F, Isogai S, Ogasawara K, Ishida K, Yuge S, Roscoe B, Wolfe SA, Fukuhara S …

Developmental cell, 51(3) 374-386, Sep, 2019 Peer-reviewed
Live imaging of angiogenesis during cutaneous wound healing in adult zebrafish.

Noishiki C* & Yuge S* (equal contribution), Ando K, Wakayama Y, Mochizuki N, Ogawa R, Fukuhara S

Angiogenesis, 22(2) 341-354, May, 2019 Peer-reviewedLead author
beta-catenin-dependent transcription is central to Bmp-mediated formation of venous vessels

Takeru Kashiwada, Shigetomo Fukuhara, Kenta Terai, Toru Tanaka, Yuki Wakayama, Koji Ando, Hiroyuki Nakajima, Hajime Fukui, Shinya Yuge, Yoshinobu Saito …

DEVELOPMENT, 142(3) 497-509, Feb, 2015 Peer-reviewed
Visualizing the cell-cycle progression of endothelial cells in zebrafish

Shigetomo Fukuhara, Jianghui Zhang, Shinya Yuge, Koji Ando, Yuki Wakayama, Asako Sakaue-Sawano, Atsushi Miyawaki, Naoki Mochizuki

DEVELOPMENTAL BIOLOGY, 393(1) 10-23, Sep, 2014 Peer-reviewed
Identification of the thiamin pyrophosphokinase gene in rainbow trout: Characteristic structure and expression of seven splice variants in tissues and cell lines and during embryo development

Shinya Yuge, Catherine A. Richter, Maureen K. Wright-Osment, Diane Nicks, Stephanie K. Saloka, Donoald E. Tillitt, Weiming Li

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 163(2) 193-202, Oct, 2012 Peer-reviewedLead author
Regulation of ion transport in eel intestine by the homologous guanylin family of peptides

Shinya Yuge, Yoshio Takei

ZOOLOGICAL SCIENCE, 24(12) 1222-1230, Dec, 2007 Peer-reviewedLead authorCorresponding author
The intestinal guanylin system and seawater adaptation in eels

Yoshio Takei, Shinya Yuge

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 152(2-3) 339-351, Jun, 2007 Peer-reviewedLast author
Identification of two functional guanylin receptors in eel: Multiple hormone-receptor system for osmoregulation in fish intestine and kidney

Shinya Yuge, Sayaka Yamagami, Koji Inoue, Norio Suzuki, Yoshio Takei

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 149(1) 10-20, Oct, 2006 Peer-reviewedLead authorCorresponding author
Identification of eel ghrelin in plasma and stomach by radioimmunoassay and histochemistry.

Hiroyuki Kaiya, Takehiro Tsukada, Shinya Yuge, Hiroko Mondo, Kenji Kangawa, Yoshio Takei

General and comparative endocrinology, 148(3) 375-82, Sep 15, 2006 Peer-reviewed
Contribution of comparative fish studies to general endocrinology: structure and function of some osmoregulatory hormones

Yoshio Takei, Akatsuki Kawakoshi, Takehiro Tsukada, Shinya Yuge, Maho Ogoshi, Koji Inoue, Susumu Hyodo, Hideo Bannai, Satoru Miyano

JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL GENETICS AND PHYSIOLOGY, 305A(9) 787-798, Sep, 2006 Peer-reviewed
Structural and functional evolution of three cardiac natriuretic peptides

K Inoue, T Sakamoto, S Yuge, H Iwatani, S Yamagami, M Tsutsumi, H Hori, MC Cerra, B Tota, N Suzuki …

MOLECULAR BIOLOGY AND EVOLUTION, 22(12) 2428-2434, Dec, 2005 Peer-reviewed
Molecular identification and immunohistochemical localization of atrial natriuretic peptide in the heart of the dromedary camel (Camelus dromedarius)

AHK Osman, S Yuge, S Hyodo, S Sato, S Maeda, H Marie, T Caceci, N Birukawa, A Urano, K Naruse …

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 139(4) 417-424, Dec, 2004 Peer-reviewed
A novel guanylin family (guanylin, uroguanylin, and renoguanylin) in eels - Possible osmoregulatory hormones in intestine and kidney

S Yuge, K Inoue, S Hyodo, Y Takei

JOURNAL OF BIOLOGICAL CHEMISTRY, 278(25) 22726-22733, Jun, 2003 Peer-reviewedLead authorCorresponding author

Misc.

生体イメージングにより解き明かされた創傷治癒における血管新生の制御機構

石井智裕, 弓削進弥, 福原茂朋

生体の科学, 73(6) 1-5, Dec, 2022 Invited
研究の効率化と生産性の向上

弓削進弥, 遠田悦子, 戸山友香, 黄美貴, 加藤卓也, 奈良井朝子

日本医科大学しあわせキャリア支援センター第3回女性・若手研究者キャリアデザインプロジェクト公開研究報告書, 21-38, Sep, 2022 Lead authorCorresponding author
Introduction of an article: Mechanical loading of intraluminal pressure mediates wound angiogenesis by regulating the TOCA family of F-BAR proteins

Yuge, S, Nishiyama, K, Fukuhara, S

Circular (The Japanese Vascular Biology and Medicine Academic Journal), 18 21-24, Aug, 2022 InvitedLead author
ライブイメージングにより血管新生におけるペリサイトの真の機能を解明する

石井智裕, 弓削進弥, 安藤康史, 福原茂朋

日本医科大学医学会雑誌, 18(1) 70-71, Feb, 2022
疾患に挑むメカノバイオロジー第2章 6. 血管新生のメカノバイオロジー

石井智裕, 弓削進弥, 福原茂朋

実験医学増刊《疾患に挑むメカノバイオロジー》, 38(7) 142-147, May, 2020 Invited
新しい医療を拓くメカノバイオロジー 5.血管新生のメカノバイオロジー

弓削進弥, 藤原正和, 福原茂朋

医薬ジャーナル, 53(6) 1451‐1454-77,10-11, Jun 1, 2017 InvitedLead author
海洋生命系のダイナミクス 2章機能系のダイナミクス多様な海洋環境に生命はどのように適応しているか? 高浸透圧環境への適応機構

竹井祥郎, 兵藤晋, 井上広滋, 長谷川早苗, 李遠友, 宮崎裕明, 川越暁, 塚田岳大, 弓削進弥

月刊海洋, 92-103, Apr 1, 2002 Invited

Books and Other Publications

Function Control and Disease Mechanism of Blood and Lymphatic Vessels

(Role: Joint author)

Aug 15, 2022 (ISBN: 9784759817355)
Handbook of Hormones, 2nd edition

Shinya Yuge (Role: Contributor, pp. 341-352 (Chapter 32, Chapter 32A and Chapter 32B))

Academic Press, Jul 27, 2021 (ISBN: 9780128206492)
Handbook of Hormones, 1st edition

Shinya Yuge (Role: Contributor, pp. 195-202 (Chapter 23: Guanylin Family; Chapter 23A: Guanylin; Chapter 23B: Uroguanylin))

Academic Press, Aug 26, 2015 (ISBN: 9780128010280)
Eel Physiology

Tsukada, T, Marty, W, Ogoshi, M, Yuge, S (Role: Joint author, pp. 178-224 (Chapter 7: Endocrine control of osmoregulation))

CRC Press, Aug 22, 2013 (ISBN: 9781466598270)

Major Presentations

Mechanical regulation of wound angiogenesis in response to intraluminal pressure

Yuge, S, Nishiyama, K, Ishii, T, Fukuhara, S

International Symposium on Mechanobiology for Human Health: 8 years progress in The AMED-CREST/PRIME project on mechanobiology, Mar 22, 2023, Japan Agency for Medical Research and Development (AMED)
Novel mechanical regulation of angiogenesis in wound healing: intraluminal pressure controls angiogenesis via TOCA family BAR domain proteins

Yuge, S, Nishiyama, K, Arima, Y, Hanada, Y, Hanada, S, Oguri-Nakamura, E, Ishii, T, Wakayama, Y, Hasegawa, U, Tsujita, K, Yokokawa, R, Miura, T, Itoh, T, Tsujita, K, Mochizuki, N, Fukuhara, S

The 30th Annual Meeting of the Japanese Vascular Biology and Medicine Organization (Cardiovascular and Metabolic Week [CVMW] 2022), Dec 16, 2022, The Japanese Vascular Biology and Medicine Organization; The Japanese Circulation Society; The International Society for Heart Research Invited
Novel mechanical regulation of angiogenesis: intraluminal pressure restricts wound angiogenesis

Yuge, S, Nishiyama, K, Arima, Y, Hanada, Y, Oguri-Nakamura, E, Hanada, S, Ishii, T, Wakayama, Y, Hasegawa, U, Tsujita, K, Yokokawa, R, Miura, T, Itoh, T, Tsujita, K, Mochizuki, N, Fukuhara, S

22nd International Vascular Biology Meeting (IVBM 2022), Oct 14, 2022
A novel angiogenic phenomenon and its underlying mechanism: intraluminal pressure restricts elongation of injured blood vessels in wound healing

Yuge, S, Nishiyama, K, Fukuhara, S

The 93th Annual Meeting of the Zoological Society of Japan, Sep 10, 2022
Mechanical loading of intraluminal pressure regulates angiogenesis in wound healing

Yuge, S, Nishiyama, K, Arima, Y, Hanada, Y, Hanada, S, Ishii, T, Wakayama, Y, Tsujita, K, Yokokawa, R, Miura, T, Itoh, T, Mochizuki, N, Fukuhara, S

The 93rd Annual Meeting of the Japanese Biochemical Society, Sep 16, 2020
A novel role of intraluminal pressure in angiogenesis during wound healing

Yuge, S, Nishiyama, K, Arima, Y, Hanada, S, Hanada, Y, Wakayama, Y, Yokokawa, R, Miura, T, Mochizuki, N, Fukuhara, S

The 42nd Annual Meeting of the Molecular Biology Society of Japan, Dec 3, 2019
ゼブラフィッシュ成魚の創傷治癒で起こる血管新生と周皮細胞のライブイメージング

弓削進弥, 安藤康史, 小川令, 福原茂朋

第87回日本医科大学医学会総会, Sep 7, 2019
Deciphering the mechanisms of angiogenesis regulated by intravascular pressure using fluorescence-based live-imaging of zebrafish

Yuge, S, Kunita, I, Arima, Y, Hanada, S, Wakayama, Y, Yokokawa, R, Miura, T, Mochizuki, N, Nishiyama, K, Fukuhara, S

The 25th Annual Meeting of the Japanese Vascular Biology and Medicine Organization (Cardiovascular and Metabolic Week [CVMW] 2017), Dec 8, 2017
A novel regulatory mechanism of angiogenesis revealed by live-imaging of adult zebrafish

Yuge, S, Kunita, I, Arima, Y, Yokokawa, R, Miura, T, Mochizuki, N, Nishiyama, K, Fukuhara, S

The 39th Annual Meeting of the Molecular Biology Society of Japan, Nov 30, 2016
Characterization and functional analyses of three thiamin related transporters and a thiamin pyrophosphokinase in rainbow trout, and examination of their expression alteration in thiamin deficiency

Yuge, S, Honeyfield, D.C, Saloka, S.K, Li, W

Society for Integrative and Comparative Biology Annual Meeting 2013, Jan 3, 2013
Complex Guanylin Family and Its Receptors in Eel: Possible Functions in Fish Osmoregulation via Intestine and Kidney

Yuge, S, Inoue, K, Hyodo, S, Takei, Y

15th International Congress of Comparative Endocrinology (ICCE), May 22, 2005

Research Projects

Investigation of Regulation of Angiogenesis by Intraluminal Pressure and Its Physiological Significance

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
Investigation of role of intraluminal pressure in physiological and pathological angiogenesis, and development of innovative treatment of angiogenesis related diseases

Nippon Medical School, Apr, 2023 - Mar, 2024

Shinya Yuge
Investigation of roles of pericytes in wound-induced angiogenesis by fluorescence imaging

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Shinya Yuge
Investigation of mechanisms of wound-induced angiogenesis using our established live-imaging of adult zebrafish

Grants-in-Aid for Scientific Research, Grants-in-Aid for Scientific Research for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2019

Shinya Yuge
Osmoregulatory Functions of a Novel Guanylin Family in Eels

Grant-in-Aid for Scientific Research, Grant-in-Aid for JSPS Fellows, Japan Society for the Promotion of Science, Apr, 2003 - Mar, 2006

Shinya Yuge

Professional Memberships

Committee Memberships

Apr, 2023 - Present

Subhead of the secretariat, The Japanese Vascular Biology and Medicine Organization
Apr, 2022 - Present

Councilor, The Japanese Vascular Biology and Medicine Organization

Major Teaching Experience

Apr, 2020 - Present

Lectures of Molecular, Cellular and Structural Biology at Advanced Level A and B (Nippon Medical School)
2017 - Present

Practical Exercises and Experiences of Biomedical Research (Nippon Medical School)
Apr, 2016 - Present

Practical Exercises and Lectures of Molecular, Cellular and Structural Biology Research (Nippon Medical School)
Oct, 2023 - Mar, 2025

生命の分子的基盤実習・生化学実習 (東京医科歯科大学歯学部歯学科)

Media Coverage

Elucidation of processes and regulation of wound angiogenesis

Asahi Shinbun, Jun 17, 2022 Newspaper, magazine

Social Activities

Workshop and Lecture for high school students supported by the JSPS: Hirameki Tokimeki Science”

Commentator, Host, Lecturer, Consultant, Planner, Performer

Nippon Medical School, Nippon Medical School, Jul 30, 2022 - Jul 30, 2022

Works

28

Trial imaging of angiogenesis in zebrafish embryos by using Nikon new confocal microscope A1/A1R HD25

Yuge, S., Fukuhara, S. and Nikon Instec (Present: Nikon Solutions)

Jul, 2018 - Aug, 2018 Other

Major Other

3rd Workshop of Lady and Young Investigators for Designing Careers in Happy-Career Supporting Center in Nippon Medical School

May, 2022 - Jul, 2022
30th Faculty Development Workshop for Medical Education in Nippon Medical School

Jun, 2017 - Jun, 2017
1st Specialized Teacher's License for Science at Junior and Senior High School

Mar, 2003 - Mar, 2003

Profile Information

Research Interests

Research Areas

Research History

Awards

Papers

Misc.

Books and Other Publications

Major Presentations

Research Projects

Professional Memberships

Committee Memberships

Major Teaching Experience

Media Coverage

Social Activities

Works

Major Other

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Coauthors