2016年3月
Rare Helicobacter pylori Virulence Genotypes in Bhutan
SCIENTIFIC REPORTS
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- 巻
- 6
- 号
- 開始ページ
- 22584
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/srep22584
- 出版者・発行元
- NATURE PUBLISHING GROUP
Both the prevalence of Helicobacter pylori infection and the incidence of gastric cancer are high in Bhutan. The high incidence of atrophic gastritis and gastric cancer suggest the phylogeographic origin of an infection with a more virulent strain of H. pylori. More than 90% of Bhutanese strains possessed the highly virulent East Asian-type CagA and all strains had the most virulent type of vacA (s1 type). More than half also had multiple repeats in East Asian-type CagA, which are rare in other countries and are reported characteristictly found in assciation with atrophic gastritis and gastric cancer consistent with Bhutanese strains having multiple H. pylori virulence factors associated with an increase in gastric cancer risk. Phylogeographic analyses showed that most Bhutanese strains belonged to the East Asian population type with some strains (17.5%) sharing East Asian and Amerindian components. Only 9.5% belonged to the European type consistant with H. pylori in Bhutan representing an intermediate evolutionary stage between H. pylori from European and East Asian countries.
- リンク情報
- ID情報
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- DOI : 10.1038/srep22584
- ISSN : 2045-2322
- PubMed ID : 26931643
- Web of Science ID : WOS:000371175200001