論文

査読有り
2016年3月

Rare Helicobacter pylori Virulence Genotypes in Bhutan

SCIENTIFIC REPORTS
  • Osamu Matsunari
  • ,
  • Muhammad Miftahussurur
  • ,
  • Seiji Shiota
  • ,
  • Rumiko Suzuki
  • ,
  • Ratha-korn Vilaichone
  • ,
  • Tomohisa Uchida
  • ,
  • Thawee Ratanachu-ek
  • ,
  • Lotay Tshering
  • ,
  • Varocha Mahachai
  • ,
  • Yoshio Yamaoka

6
開始ページ
22584
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/srep22584
出版者・発行元
NATURE PUBLISHING GROUP

Both the prevalence of Helicobacter pylori infection and the incidence of gastric cancer are high in Bhutan. The high incidence of atrophic gastritis and gastric cancer suggest the phylogeographic origin of an infection with a more virulent strain of H. pylori. More than 90% of Bhutanese strains possessed the highly virulent East Asian-type CagA and all strains had the most virulent type of vacA (s1 type). More than half also had multiple repeats in East Asian-type CagA, which are rare in other countries and are reported characteristictly found in assciation with atrophic gastritis and gastric cancer consistent with Bhutanese strains having multiple H. pylori virulence factors associated with an increase in gastric cancer risk. Phylogeographic analyses showed that most Bhutanese strains belonged to the East Asian population type with some strains (17.5%) sharing East Asian and Amerindian components. Only 9.5% belonged to the European type consistant with H. pylori in Bhutan representing an intermediate evolutionary stage between H. pylori from European and East Asian countries.

リンク情報
DOI
https://doi.org/10.1038/srep22584
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26931643
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000371175200001&DestApp=WOS_CPL
ID情報
  • DOI : 10.1038/srep22584
  • ISSN : 2045-2322
  • PubMed ID : 26931643
  • Web of Science ID : WOS:000371175200001

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