2003年9月1日
92(P-20) 抗腫瘍性抗生物質phomopsidinの全合成研究(ポスター発表の部)
天然有機化合物討論会講演要旨集
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- 巻
- 号
- 45
- 開始ページ
- 545
- 終了ページ
- 550
- 記述言語
- 日本語
- 掲載種別
- DOI
- 10.24496/tennenyuki.45.0_545
- 出版者・発行元
- 天然有機化合物討論会
Phomopsidin was isolated from Phompsis sp. TUF95F47 by Namikoshi and co-workers in 1997, and its absolute structure and biological activity have been reported. Phomopsidin and its geometrical isomer (MK8383) showed potent inhibitory activity against assembly of microtubule proteins, exhibiting strong antitumor activity. It has been proposed that phomopsidin could be generated via the IMDA reaction of 1. Therefore, the potent antitumor activity and this biosynthetic background draw our attention to the synthesis of phomopsidin. We planned to synthesize the cis-decalin core 2 of phomopsidin f...
- リンク情報
- ID情報
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- DOI : 10.24496/tennenyuki.45.0_545
- CiNii Articles ID : 110006682351
- CiNii Books ID : AN00154136
- identifiers.cinii_nr_id : 9000006709345