論文

査読有り 国際誌
2020年1月

Intestinal M cells: Tireless samplers of enteric microbiota.

Traffic (Copenhagen, Denmark)
  • Takashi Kanaya
  • ,
  • Ifor R Williams
  • ,
  • Hiroshi Ohno

21
1
開始ページ
34
終了ページ
44
記述言語
英語
掲載種別
DOI
10.1111/tra.12707

Mucosal immune responses in the inductive lymphoid tissues of the intestine begin with uptake of particulate antigens, including components of the gut microbiota by specialized antigen sampling M cells. M cells represent a distinct lineage of enterocytes that arise from crypt stem cells in response to the cytokine receptor of NF-κB ligand (RANKL). Full differentiation of M cells requires the transcription factor Spi-B to yield mature M cells that express multiple receptors for bacteria including glycoprotein 2. M cell differentiation can be recapitulated in vitro using three-dimensional enteroid cultures of primary intestinal stem cells supplemented with RANKL. This article summarizes the current knowledge about the genesis of intestinal M cells and highlights some of the remaining unanswered questions about this enigmatic cell type.

リンク情報
DOI
https://doi.org/10.1111/tra.12707
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31647148

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