2010年8月1日
Mib-Jag1-Notch signalling regulates patterning and structural roles of the notochord by controlling cell-fate decisions.
Development (Cambridge, England)
- 巻
- 137
- 号
- 15
- 開始ページ
- 2527
- 終了ページ
- 37
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1242/dev.051011
- 出版者・発行元
- COMPANY OF BIOLOGISTS LTD
In the developing embryo, cell-cell signalling is necessary for tissue patterning and structural organization. During midline development, the notochord plays roles in the patterning of its surrounding tissues while forming the axial structure; however, how these patterning and structural roles are coordinated remains elusive. Here, we identify a mechanism by which Notch signalling regulates the patterning activities and structural integrity of the notochord. We found that Mind bomb (Mib) ubiquitylates Jagged 1 (Jag1) and is essential in the signal-emitting cells for Jag1 to activate Notch signalling. In zebrafish, loss- and gain-of-function analyses showed that Mib-Jag1-Notch signalling favours the development of non-vacuolated cells at the expense of vacuolated cells in the notochord. This leads to changes in the peri-notochordal basement membrane formation and patterning surrounding the muscle pioneer cells. These data reveal a previously unrecognized mechanism regulating the patterning and structural roles of the notochord by Mib-Jag1-Notch signalling-mediated cell-fate determination.
- リンク情報
-
- DOI
- https://doi.org/10.1242/dev.051011
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/20573700
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927672
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000279828300010&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?eid=2-s2.0-77955763757&partnerID=MN8TOARS
- URL
- http://orcid.org/0000-0002-9475-6495
- ID情報
-
- DOI : 10.1242/dev.051011
- ISSN : 0950-1991
- ORCIDのPut Code : 36480041
- PubMed ID : 20573700
- PubMed Central 記事ID : PMC2927672
- SCOPUS ID : 77955763757
- Web of Science ID : WOS:000279828300010