論文

査読有り 国際誌
2016年11月3日

Factors Affecting the Baseline and Post-Treatment Scores on the Hopkins Verbal Learning Test-Revised Japanese Version before and after Whole-Brain Radiation Therapy

International Journal of Molecular Sciences
  • Hirotake Saito
  • ,
  • Kensuke Tanaka
  • ,
  • Ayae Kanemoto
  • ,
  • Toshimichi Nakano
  • ,
  • Eisuke Abe
  • ,
  • Hidefumi Aoyama

17
11
開始ページ
1834
終了ページ
1834
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3390/ijms17111834
出版者・発行元
MDPI AG

Our objectives were to (1) investigate the feasibility of the use of the Japanese version of the Hopkins Verbal Learning Test-Revised (HVLT-R); (2) identify the clinical factors influencing the HVLT-R scores of patients undergoing whole-brain radiation therapy (WBRT); and (3) compare the neurocognitive function (NCF) after WBRT in different dose fractionation schedules. We administered the HVLT-R (Japanese version) before (baseline) and at four and eight months after WBRT in 45 patients who received either therapeutic (35Gy-in-14, n = 16; 30Gy-in-10, n = 18) or prophylactic (25Gy-in-10, n = 11) WBRT. Sixteen patients dropped out before the eight-month examination, due mostly to death from cancer. The Karnofsky Performance Status (KPS) 80-100 group had significantly higher baseline total recall (TR) scores (p = 0.0053), delayed recall (DR) scores (p = 0.012), and delayed recognition (DRecog) scores (p = 0.0078). The patients aged ≤65 years also had significantly higher TR scores (p = 0.030) and DRecog scores (p = 0.031). The patients who underwent two examinations (worse-prognosis group) had significantly decreased DR scores four months after WBRT compared to the baseline (p = 0.0073), and they were significantly more likely to have declined individual TR scores (p = 0.0017) and DR scores (p = 0.035) at four months. The eight-month HVLT-R scores did not significantly decline regardless of the WBRT dose fractionation. The baseline NCF was determined by age and KPS, and the early decline in NCF is characteristic of the worse-prognosis group.

リンク情報
DOI
https://doi.org/10.3390/ijms17111834
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27827891
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133835
URL
http://www.mdpi.com/1422-0067/17/11/1834/pdf
ID情報
  • DOI : 10.3390/ijms17111834
  • eISSN : 1422-0067
  • PubMed ID : 27827891
  • PubMed Central 記事ID : PMC5133835

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