論文

査読有り
2018年2月2日

Relationships between serum leptin levels and bone mineral parameters in school-aged children: a 3-year follow-up study

Journal of Bone and Mineral Metabolism
  • Katsuyasu Kouda
  • ,
  • Kumiko Ohara
  • ,
  • Yuki Fujita
  • ,
  • Harunobu Nakamura
  • ,
  • Takahiro Tachiki
  • ,
  • Masayuki Iki

開始ページ
1
終了ページ
9
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00774-018-0909-0
出版者・発行元
Springer Tokyo

Leptin regulates bone cell differentiation and functions via direct and indirect actions in experimental settings. Epidemiologically, however, the impact of leptin on the regulation of bone metabolism remains unclear. While some studies have reported a positive relationship between leptin and bone mineral parameters, other studies found an inverse or no association. We analyzed data from a population-based follow-up survey of community-dwelling children in Hamamatsu, Japan, to investigate relationships between leptin levels and bone mineral parameters. Multiple regression analysis was performed. Multicollinearity was quantified using the variance infiltration factor (VIF). Among 408 children who participated in the baseline survey (at age 11.2 years), 254 (121 boys and 133 girls) completed the follow-up survey (at age 14.2 years). Leptin levels were strongly related to fat mass (r = 0.87 in boys, r = 0.80 in girls). Leptin levels at baseline were significantly (P &lt
0.05) positively related to total body less head (TBLH) areal bone mineral density (aBMD) at follow-up in girls (standardized partial regression coefficient: β = 0.302, VIF = 2.246), after adjusting for body fat percentage (%). On the other hand, leptin levels were inversely related to TBLH aBMD in boys (β = − 0.395, VIF = 4.116), after adjusting for body fat mass (kg). Positive relationships between leptin levels and bone mineral parameters were observed with VIF values &lt
4.0, whereas inverse relationships were observed with VIF values ≥ 4.0. These findings suggest that positive relationships between leptin levels and bone mineral parameters are weak, or not always observed, due to statistical problems (i.e., multicollinearity) and other factors derived from adipose tissue.

リンク情報
DOI
https://doi.org/10.1007/s00774-018-0909-0
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29396721

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