論文

国際誌
2021年4月2日

Biosynthesis of Cyclochlorotine: Identification of the Genes Involved in Oxidative Transformations and Intramolecular O,N-Transacylation.

Organic letters
  • Yulu Jiang
  • ,
  • Taro Ozaki
  • ,
  • Chengwei Liu
  • ,
  • Yuya Igarashi
  • ,
  • Ying Ye
  • ,
  • Shoubin Tang
  • ,
  • Tao Ye
  • ,
  • Jun-Ichi Maruyama
  • ,
  • Atsushi Minami
  • ,
  • Hideaki Oikawa

23
7
開始ページ
2616
終了ページ
2620
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1021/acs.orglett.1c00525

Mycotoxin cyclochlorotine (1) and structurally related astins are cyclic pentapeptides containing unique nonproteinogenic amino acids, such as β-phenylalanine, l-allo-threonine, and 3,4-dichloroproline. Herein, we report the biosynthetic pathway for 1, which involves intriguing tailoring processes mediated by DUF3328 proteins, including stereo- and regiospecific chlorination and hydroxylation and intramolecular O,N-transacylation. Our findings demonstrate that DUF3328 proteins, which are known to be involved in oxidative cyclization of fungal ribosomal peptides, have much higher functional diversity than previously expected.

リンク情報
DOI
https://doi.org/10.1021/acs.orglett.1c00525
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33736433
ID情報
  • DOI : 10.1021/acs.orglett.1c00525
  • PubMed ID : 33736433

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