2018年6月
CD57 (Leu-7, HNK-1) immunoreactivity seen in thin arteries in the human fetal lung.
Anatomy & cell biology
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- 巻
- 51
- 号
- 2
- 開始ページ
- 105
- 終了ページ
- 112
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.5115/acb.2018.51.2.105
CD57 (synonyms: Leu-7, HNK-1) is a well-known marker of nerve elements including the conductive system of the heart, as well as natural killer cells. In lung specimens from 12 human fetuses at 10-34 weeks of gestation, we have found incidentally that segmental, subsegmental, and more peripheral arteries strongly expressed CD57. Capillaries near developing alveoli were often or sometimes positive. The CD57-positive tissue elements within intrapulmonary arteries seemed to be the endothelium, internal elastic lamina, and smooth muscle layer, which corresponded to tissue positive for a DAKO antibody reactive with smooth muscle actin we used. However, the lobar artery and pulmonary arterial trunk as well as bronchial arteries were negative. Likewise, arteries in and along any abdominal viscera, as well as the heart, thymus, and thyroid, did not express CD57. Thus, the lung-specific CD57 reactivity was not connected with either of an endodermal- or a branchial arch-origin. CD57 antigen is a sugar chain characterized by a sulfated glucuronic acid residue that is likely to exist in some glycosphingolipids. Therefore, a chemical affinity or an interaction might exist between CD57-positive arterioles and glycosphingolipids originating from alveoli, resulting in acceleration of capillary budding to make contact with the alveolar wall. CD57 might therefore be a functional marker of the developing air-blood interface that characterizes the fetal lung at the canalicular stage.
- リンク情報
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- DOI
- https://doi.org/10.5115/acb.2018.51.2.105
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/29984055
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026825
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000438205500006&DestApp=WOS_CPL
- ID情報
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- DOI : 10.5115/acb.2018.51.2.105
- ISSN : 2093-3665
- PubMed ID : 29984055
- PubMed Central 記事ID : PMC6026825
- Web of Science ID : WOS:000438205500006