Tomoya Maeda

Profile Information

Degree: Ph.D.(Tokyo Institute of Technology)

J-GLOBAL ID: 201801003191000738
researchmap Member ID: B000292277

Research Interests

Research Areas

Research History

Apr, 2025 - Present

Associate professor, Division of Fundamental AgriScience Research, Hokkaido University
2021 - Present

Visiting Researcher, Center for Biosystems Dynamics Research, RIKEN
Feb, 2021 - Mar, 2025

Assistant professor, Graduate School of Agriculture Research Faculty of Agriculture, Hokkaido University
Apr, 2018 - Jan, 2021

Special Postdoctoral Researcher, Center for Biosystems Dynamics Research, RIKEN
Jan, 2016 - Mar, 2017

Postdoctoral researcher, Quantitative Biology Center, RIKEN
Sep, 2013 - Dec, 2015

Researcher, Molecular Microbiology and Biotechnology Group, Research Institute of Innovative Technology for the Earth
Jul, 2012 - Aug, 2013

Postdoctoral researcher, Institute of Bio-and Geosciences, Biotechnology IBG-1, Forschungszentrum Jülich
Apr, 2012 - Jun, 2012

Postdoctoral researcher, Productive Leader Incubation Platform (PLIP), Tokyo Institute of Technology

Education

Apr, 2008 - Mar, 2012

Department of Bioengineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Graduate School
Sep, 2009 - Mar, 2010

Institute for Biochemistry, University of Cologne
Apr, 2004 - Mar, 2008

Department of Bioengineering, School of Bioscience and Biotechnology, Tokyo Institute of Technology

Awards

Jan, 2021

Presentation award Biology Prize, 理化学研究所
Mar, 2012

鎌田泉博士論文賞, 生物工学研究会

前田智也

Papers

EASY-CRISPR: a toolbox for high-throughput single-step custom genetic editing in bacteria

Maxence Lejars, Tomoya Maeda, Maude Guillier

bioRxiv, Mar 20, 2025
Methodology and Application of Adaptive Laboratory Evolution for Antimicrobial Resistance and Bioproduction

Kagaku to Seibutsu, 63(3) 114-122, Mar 1, 2025 Peer-reviewedInvitedLead authorCorresponding author
Improved fermentative gamma-aminobutyric acid production from glucose by the inactivation of respiratory chain components NDH-I and Cytbo₃ in Escherichia coli.

Hiroki Wakahara, Takuya Mizokoshi, Kotaro Yamagami, Satoru Fukiya, Atsushi Yokota, Tomoya Maeda

Journal of bioscience and bioengineering, Sep 7, 2024 Peer-reviewedLast authorCorresponding author
Contributions of the anaplerotic reaction enzymes pyruvate carboxylase and phosphoenolpyruvate carboxylase to l-lysine production in Corynebacterium glutamicum.

Akinobu Shinmori, Zhen Guo, Tomoya Maeda, Satoru Fukiya, Masaru Wada, Atsushi Yokota

Journal of bioscience and bioengineering, Jun 27, 2024 Peer-reviewed
Laboratory Evolution of Antimicrobial Resistance in Bacteria to Develop Rational Treatment Strategies

Tomoya Maeda, Chikara Furusawa

Antibiotics, 13(1) 94-94, Jan 18, 2024 Peer-reviewedInvitedLead authorCorresponding author
Inference of Fitness Landscape Based on Multi-Dimensional Phenotype Measurements of <i>Escherichia coli</i>

Chikara FURUSAWA, Junichiro IWASAWA, Tomoya MAEDA

Seibutsu Butsuri, 63(5) 263-265, 2023
Adaptive Laboratory Evolution of Microorganisms: Methodology and Application for Bioproduction.

Takashi Hirasawa, Tomoya Maeda

Microorganisms, 11(1), Dec 29, 2022 Peer-reviewedInvited
Analysis of the evolution of resistance to multiple antibiotics enables prediction of the Escherichia coli phenotype-based fitness landscape.

Junichiro Iwasawa, Tomoya Maeda, Atsushi Shibai, Hazuki Kotani, Masako Kawada, Chikara Furusawa

PLoS biology, 20(12) e3001920, Dec, 2022 Peer-reviewed
A manually curated compendium of expression profiles for the microbial cell factory Corynebacterium glutamicum.

Angela Kranz, Tino Polen, Christian Kotulla, Annette Arndt, Graziella Bosco, Michael Bussmann, Ava Chattopadhyay, Annette Cramer, Cedric-Farhad Davoudi, Ursula Degner …

Scientific data, 9(1) 594-594, Oct 1, 2022 Peer-reviewed
Multi-dimensional antibiotic resistance time series reveals the phenotype-based fitness landscape for Escherichia coli

Junichiro Iwasawa, Tomoya Maeda, Atsushi Shibai, Hazuki Kotani, Masako Kawada, Chikara Furusawa

Aug 24, 2022
Acceleration of target production in co-culture by enhancing intermediate consumption through adaptive laboratory evolution.

Ryutaro Kawai, Yoshihiro Toya, Kenta Miyoshi, Manami Murakami, Teppei Niide, Takaaki Horinouchi, Tomoya Maeda, Atsushi Shibai, Chikara Furusawa, Hiroshi Shimizu

Biotechnology and bioengineering, 119(3) 936-945, Dec 16, 2021 Peer-reviewed
Laboratory evolution of Mycobacterium on agar plates for analysis of resistance acquisition and drug sensitivity profiles.

Tomoya Maeda, Masako Kawada, Natsue Sakata, Hazuki Kotani, Chikara Furusawa

Scientific reports, 11(1) 15136-15136, Jul 23, 2021 Peer-reviewedLead authorCorresponding author
Mutational property of newly identified mutagen l-glutamic acid γ-hydrazide in Escherichia coli.

Tomoya Maeda, Atsushi Shibai, Naomi Yokoi, Yumeko Tarusawa, Masako Kawada, Hazuki Kotani, Chikara Furusawa

Mutation research, 823 111759-111759, Jul 21, 2021 Peer-reviewedLead authorCorresponding author
Morphological change of coiled bacterium Spirosoma linguale with acquisition of β-lactam resistance.

Tomoya Maeda, Hazuki Kotani, Chikara Furusawa

Scientific reports, 11(1) 13278-13278, Jun 24, 2021 Peer-reviewedLead authorCorresponding author
Relevance of NADH Dehydrogenase and Alternative Two-Enzyme Systems for Growth of Corynebacterium glutamicum With Glucose, Lactate, and Acetate

Tomoya Maeda, Abigail Koch-Koerfges, Michael Bott

Frontiers in Bioengineering and Biotechnology, 8, Jan 20, 2021 Peer-reviewedLead author
High-throughput laboratory evolution reveals evolutionary constraints in Escherichia coli

Tomoya Maeda, Junichiro Iwasawa, Hazuki Kotani, Natsue Sakata, Masako Kawada, Takaaki Horinouchi, Aki Sakai, Kumi Tanabe, Chikara Furusawa

Nature Communications, 11(1) 5970-5970, Nov, 2020 Peer-reviewedLead authorCorresponding author
Suppression of antibiotic resistance evolution by single-gene deletion.

Takaaki Horinouchi, Tomoya Maeda, Hazuki Kotani, Chikara Furusawa

Scientific reports, 10(1) 4178-4178, Mar 6, 2020 Peer-reviewed
Complete Genome Sequences of Three Star-Shaped Bacteria, Stella humosa, Stella vacuolata, and Stella Species ATCC 35155

Atsushi Shibai, Tomoya Maeda, Masako Kawada, Hazuki Kotani, Natsue Sakata, Chikara Furusawa

Microbiology Resource Announcements, 8(32), Aug 8, 2019 Peer-reviewedCorresponding author
High-throughput identification of the sensitivities of an Escherichia coli ΔrecA mutant strain to various chemical compounds.

Maeda T, Horinouchi T, Sakata N, Sakai A, Furusawa C

The Journal of antibiotics, 72(7) 566-573, Feb, 2019 Peer-reviewedLead authorCorresponding author
RNase E/G-dependent degradation of metE mRNA, encoding methionine synthase, in Corynebacterium glutamicum

Satoshi Endo, Tomoya Maeda, Takahiro Kawame, Noritaka Iwai, Masaaki Wachi

The Journal of General and Applied Microbiology, 65(1) 47-52, 2019 Peer-reviewed

Misc.

Isoprenol production by co-culture with two Escherichia coli strains with consuming different carbon sources

村上茉奈美, 川井隆太郎, 三吉健太, 芝井厚, 前田智也, 堀之内貴明, 古澤力, 古澤力, 戸谷吉博, 清水浩

日本生物工学会大会講演要旨集, 74th, 2022
Genomic mutation analysis of an evolved strain with enhanced mevalonate consumption

村上茉奈美, 川井隆太郎, 前田智也, 堀之内貴明, 古澤力, 古澤力, 戸谷吉博, 清水浩

日本生物工学会大会講演要旨集, 73rd, 2021
代謝シミュレーションと指向性進化に基づく有用物質生産微生物の開発

戸谷吉博, 川井隆太郎, 三吉健太, 村上茉奈美, 一色衣香, 堀之内貴明, 前田智也, 古澤力, 清水浩

化学工学会秋季大会研究発表講演要旨集(CD-ROM), 52nd, 2021
Directed evolution for enhancing mevalonate uptake ability in Escherichia coli under a continuous culture

村上茉奈美, 川井隆太郎, 前田智也, 堀之内貴明, 古澤力, 戸谷吉博, 清水浩

日本農芸化学会大会講演要旨集(Web), 2021, 2021
機械学習と大腸菌実験室進化データを用いた進化拘束の解析

岩澤諄一郎, 前田智也, 堀之内貴明, 古澤力, 古澤力

日本ゲノム微生物学会年会要旨集, 14th, 2020
Phenotypic and genotypic analysis of laboratory evolution of Escherichia coli: Toward prediction and control of ecosystem evolution

古澤力, 前田智也, 芝井厚

実験医学, 38(18), 2020
全自動培養システムを用いた多種ストレス環境下における大腸菌の大規模実験室進化

前田智也, 岩澤諄一郎, 堀之内貴明, 阪田奈津枝, 小谷葉月, 川田正子, 田邊久美, 古澤力, 古澤力

日本ゲノム微生物学会年会要旨集, 13th, 2019
全自動培養システムを用いた多種ストレス環境下における大腸菌の大規模実験室進化

前田智也, 堀之内貴明, 阪田奈津江, 小谷葉月, 酒井亜希, 田邊久美, 古澤力, 古澤力

日本ゲノム微生物学会年会要旨集, 12th, 2018
大規模実験室進化を用いた転写因子の破壊による大腸菌の薬剤耐性化の制御

堀之内貴明, 前田智也, 小谷葉月, 酒井亜希, 古澤力, 古澤力

日本生物工学会大会講演要旨集, 70th, 2018
全自動培養システムを用いた多種ストレス環境化における大腸菌進化ダイナミクスの解析

前田智也, 堀之内貴明, 阪田奈津枝, 小谷葉月, 酒井亜希, 田邊久美, 古澤力, 古澤力

日本ゲノム微生物学会年会要旨集, 11th, 2017
超大規模実験室進化とオミックス解析による大腸菌のストレス耐性機構の解析

堀之内貴明, 前田智也, 古澤力, 古澤力

日本生物工学会大会講演要旨集, 69th, 2017
大腸菌進化実験による進化的制約の解析

古澤力, 古澤力, 前田智也, 堀之内貴明

日本進化学会大会プログラム・講演要旨集(Web), 19th, 2017
1P-046 Analysis of mRNA recognition mechanism of Corynebacterium glutamicum RNase E/G

Endo Satoshi, Maeda Tomoya, Wachi Masaaki

66 28-28, 2014
2P-031 5'-UTR dependent degradation of mRNAs by RNase E/G in Corynebacterium glutamicum

Endo Satoshi, Maeda Tomoya, Wachi Masaaki

65 111-111, 2013

Presentations

異種間相互作用が抗生物質耐性進化に及ぼす影響

前田智也

日本農芸化学会2025年度札幌大会, Mar 7, 2025
Analysis of dependence and independence of microbial community assembly on carbon sources through community assembly experiments.

Tomoya Maeda, Junpei F Yamagish, Chikara Furusawa

EMBO Workshop Molecular mechanisms in evolution and ecology, Oct 9, 2024
大規模継代培養実験による微生物生態系の再構成

前田智也

第4回シンポジウムビフィズス菌研究会, Sep 29, 2023 Invited
Comparative analysis of antibiotic resistance dynamics by high-throughput laboratory evolution of 9 bacterial species

Tomoya Maeda, Kumi Tanabe, Atsushi Shibai, Hazuki Kotani, Chikara Furusawa

FEMS (Federation of European Microbiological Societies) 2023, Jul 10, 2023
Cutting-edge technologies and their applications in microbiology

Jianshi Jin, Tomoya Maeda

The 45th Annual Meeting of the Molecular Biology Society of Japan, Nov 30, 2022
Relationship among energy level, redox balance, and phenotype in Escherichia coli

Tomoya Maeda

Sep 14, 2022 Invited
異種間相互作用による薬剤耐性進化ダイナミクスへの影響

前田智也, 古澤力

新学術領域「ポストコッホ生態」－ACT-X「環境とバイオテクノロジー」合同シンポジウム, Sep 1, 2021 Invited
実験室進化による薬剤耐性進化ダイナミクスの解析

前田智也, 古澤力

第15回細菌学若手コロッセウム, Aug 30, 2021 Invited
実験室進化による薬剤耐性進化ダイナミクスの解析

前田智也, 岩澤諄一郎, 古澤力

日本生物工学会【北日本支部】2021年度第一回オンライン若手シンポジウム, Aug 26, 2021 Invited
大規模進化実験で解き明かす大腸菌の薬剤耐性進化における制約

前田智也, 岩澤諄一郎, 古澤力

第94回日本細菌学会総会シンポジウム「若手研究者による最先端研究：細菌学の明日を切り拓く若人たちの発想と挑戦、今此処に！」, Mar 23, 2021 Invited

Professional Memberships

Research Projects

非病原性ウシ型結核菌BCG株を用いた進化実験による多剤耐性進化可能性の検証

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2024 - Mar, 2028

前田智也
Analysis of evolutionary dynamics of ecosystem using automated culture system

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2023 - Mar, 2026
Consolidated PHA production from marine biomass

ALCA-Next（Advanced Technologies for Carbon-Neutral）, Japan Science and Technology Agency, Sep, 2024 - Mar, 2026

Takasuka Taichi, Maeda Tomoya
腸内マイクロバイオームの大規模継代培養による栄養共生関係の解明

科学研究費助成事業新学術領域研究(研究領域提案型), 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2022 - Mar, 2024

前田智也
適応的実験室進化による産業微生物のエネルギー欠乏への潜在的な適応能力の解明

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

前田智也
Metabolic analysis of an Escherichia coli mutant defective in respiratory chain enzymes and its application to the production of 1,3-butanediol and gamma-aminobutyric acid.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Atsushi Yokota
Identification of interaction network of environmental microorganisms by high-throughput laboratory evolution.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2022
Construction and analysis of bacterial strains carrying heterologous bacterial genome by heterologous protoplast fusion.

Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2020

Maeda Tomoya
Development of interspecies genome recombination method using cell fusion and CRISPR/Cas9 technique

NISR Young Investigator Research Grants, Noda Institute for Scientific Research, Apr, 2019 - Mar, 2020

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